nls

NLS (PKKKRKV) is a peptide derived from the 40 tumor antigen of the great ape virus (SV40 big T antigen), which is a method to enhance the nuclear portal in the research field of gene transfer.

NLS PKKKRKV acetate is a peptide derived from the 40 tumor antigen of the great ape virus (SV40 big T antigen), which is a method to enhance the nuclear portal in the research field of gene transfer.

This peptide, a nuclear localization signal DNA tagged to this peptide efficiently translocates into the cell nucleus.

SV40 T-Ag-derived NLS peptide acetate (SV40 T-Ag-derived NLS peptide acetate) is a nuclear localization signal peptide. The DNA labeled with this peptide can be effectively transferred to the nucleus.

SV40 large T antigen NLS, originating from Large T antigen residue 47 to 55, facilitates protein import into the cell nucleus. This peptide is specifically generated from Large T antigen residue 47 to 55.

SV40 large T antigen NLS acetate is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.

Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

NLS-CPP is a nuclear localization signal (NLS)-cell penetrating peptide that includes the NLS from OCT6. It facilitates nuclear delivery and can be utilized in the study of chronic inflammatory diseases, including metabolic dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA).

NLS-StAx-h TFA is a selective and cell-permeable stapled peptide that inhibits Wnt signaling with an IC50 value of 1.4 μM, effectively suppressing β-catenin-transcription factor interactions and demonstrating anti-proliferative effects on cancer cells [1] [2].

NLS (PKKKRKV)TFA is the TFA form of NLS (PKKKRKV). Derived from the simian virus 40 large T antigen, NLS (PKKKRKV) functions as a nuclear localization signal (NLS) that facilitates the binding of nucleophilic proteins with importin α. It serves as a method to enhance nuclear entry in gene transfer research.

CP-EPS8-NLS is a peptide with anti-AML properties. It disrupts ESP8-related signaling and exhibits anti-AML activity across various AML cell types. Additionally, CP-EPS8-NLS demonstrates potent antitumor effects in xenograft tumor models. It effectively downregulates EPS8 expression along with its downstream pathways.

NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV). This compound is a nuclear localization signal (NLS) derived from the SV40 large T antigen of simian virus 40, and it facilitates the binding of nucleophilic proteins to importin α. NLS (PKKKRKV) can be utilized to enhance nuclear entry in the field of gene transfer research.

mNLS-CPP-WSTF is a nuclear localization signal (NLS)-cell penetrating peptide derived from the mouse WSTF sequence. This compound significantly inhibits the interaction between GABARAP and WSTF, WSTF degradation, and the expression of inflammatory genes. It effectively alleviates chronic inflammation, liver fibrosis, and cartilage damage in mouse models of metabolism-associated steatohepatitis (MASH) and osteoarthritis (OA). mNLS-CPP-WSTF shows research potential for chronic inflammatory diseases such as MASH and OA.

mNLS-CPP-WSTFTFA is the trifluoroacetate salt form of mNLS-CPP-WSTF, a cell-penetrating peptide based on the mouse WSTF sequence with a nuclear localization signal (NLS). This compound significantly inhibits the interaction between GABARAP and WSTF, as well as WSTF degradation and the expression of inflammatory genes. It effectively alleviates chronic inflammation, liver fibrosis, and cartilage damage in mouse models of metabolic dysfunction-associated steatotic hepatitis (MASH) and osteoarthritis (OA). mNLS-CPP-WSTF holds research potential for chronic inflammatory diseases such as MASH and OA.

mNLS-CPP-scramble serves as a negative control peptide for mNLS-CPP-WSTF. It shows potential for research into chronic inflammatory diseases, such as MASH and osteoarthritis.

mNLS-CPP-scramble (TFA) is the trifluoroacetate salt form of mNLS-CPP-scramble. Serving as a negative control peptide for mNLS-CPP-WSTF, it holds potential for research in chronic inflammatory diseases, such as MASH and osteoarthritis.

Lauroylsarcosine sodium salt(Sarkosyl NL sodium) is an anionic surfactant and detergent with protein denaturing properties commonly used in molecular biology research for purification of membrane proteins, promotion of cell lysis in RNA purification experiments and membrane solubilization, and toxicity to A549 cells after ALIF or SME exposure.

Tubulin/LSD1-IN-1 is a potent dual inhibitor of tubulin polymerization and LSD1 (IC50 = 1.72 μM), exhibiting broad-spectrum antiproliferative activity against cancer cell lines. By targeting the colchicine binding site, it disrupts the microtubule network in gastric cancer cells. Tubulin/LSD1-IN-1 enhances methylation levels of H3K4me1/2 and H3K9me2/3, facilitating epigenetic regulation. It induces G2/M phase arrest, promotes apoptosis, and effectively inhibits colony formation in gastric cancer cells.

Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and invasive effects, it effectively impacts pancreatic cancer BxPC-3 and PANC-1 cells.

Biotin-KKKRKV acetate, the biotinylated form of the nuclear localization signal (NLS) peptide KKKRKV from simian virus 40 [1], serves as a specialized compound for targeted molecular applications.

DSPE-PEG1000-MPG is a PEG compound composed of DSPE and the peptide carrier (MPG). MPG is derived from the nuclear localization sequence (NLS) of the SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG efficiently delivers short oligonucleotides into cells, operating independently of endosomal pathways.

DSPE-PEG2000-MPG is a PEG compound composed of DSPE and the peptide carrier (MPG). The MPG component is derived from the nuclear localization sequence (NLS) of the SV40 large T antigen and the fusion peptide domain of HIV-1gp41. It effectively delivers short oligonucleotides into cells independently of the endosomal pathway.

DSPE-PEG5000-MPG is a PEG compound composed of DSPE and a peptide carrier (MPG). MPG is derived from the nuclear localization sequence (NLS) of the SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. This compound effectively delivers short oligonucleotides into cells independently of the endosomal pathway.

DSPE-PEG3400-MPG is a PEG compound composed of DSPE and a peptide carrier (MPG). MPG is derived from the nuclear localization sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1gp41. MPG efficiently delivers short oligonucleotides into cells independently of the endosomal pathway.