nls

NLS (PKKKRKV) is a peptide derived from the 40 tumor antigen of the great ape virus (SV40 big T antigen), which is a method to enhance the nuclear portal in the research field of gene transfer.

NLS PKKKRKV acetate is a peptide derived from the 40 tumor antigen of the great ape virus (SV40 big T antigen), which is a method to enhance the nuclear portal in the research field of gene transfer.

This peptide, a nuclear localization signal DNA tagged to this peptide efficiently translocates into the cell nucleus.

SV40 large T antigen NLS, originating from Large T antigen residue 47 to 55, facilitates protein import into the cell nucleus. This peptide is specifically generated from Large T antigen residue 47 to 55.

Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

NLS-CPP is a nuclear localization signal (NLS)-cell penetrating peptide that includes the NLS from OCT6. It facilitates nuclear delivery and can be utilized in the study of chronic inflammatory diseases, including metabolic dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA).

SV40 T-Ag-derived NLS peptide acetate (SV40 T-Ag-derived NLS peptide acetate) is a nuclear localization signal peptide. The DNA labeled with this peptide can be effectively transferred to the nucleus.

NLS-StAx-h TFA is a selective and cell-permeable stapled peptide that inhibits Wnt signaling with an IC50 value of 1.4 μM, effectively suppressing β-catenin-transcription factor interactions and demonstrating anti-proliferative effects on cancer cells [1] [2].

CP-EPS8-NLS is a peptide with anti-AML properties. It disrupts ESP8-related signaling and exhibits anti-AML activity across various AML cell types. Additionally, CP-EPS8-NLS demonstrates potent antitumor effects in xenograft tumor models. It effectively downregulates EPS8 expression along with its downstream pathways.

SV40 large T antigen NLS acetate is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.

mNLS-CPP-WSTF is a nuclear localization signal (NLS)-cell penetrating peptide derived from the mouse WSTF sequence. This compound significantly inhibits the interaction between GABARAP and WSTF, WSTF degradation, and the expression of inflammatory genes. It effectively alleviates chronic inflammation, liver fibrosis, and cartilage damage in mouse models of metabolism-associated steatohepatitis (MASH) and osteoarthritis (OA). mNLS-CPP-WSTF shows research potential for chronic inflammatory diseases such as MASH and OA.

mNLS-CPP-scramble serves as a negative control peptide for mNLS-CPP-WSTF. It shows potential for research into chronic inflammatory diseases, such as MASH and osteoarthritis.

Biotin-KKKRKV acetate, the biotinylated form of the nuclear localization signal (NLS) peptide KKKRKV from simian virus 40 [1], serves as a specialized compound for targeted molecular applications.