mtor inhibitor 13

mTOR inhibitor 13 is a selective mTOR inhibitor with IC50 of 0.29nM and 119nM for mTOR and PI3Kα, respectively.

PI3K mTOR Inhibitor-13, an orally active dual inhibitor targeting phosphoinositol 3-kinase (PI3K) and mTOR kinase, holds potential for treating sexual diseases, solid tumors, and idiopathic pulmonary fibrosis (IPF).

CC-115 is a inhibitor of mTOR DNA-PK (IC50= 21 13 nM).

TBK1 IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced activity, by 100- to 1000-fold, against other protein kinases, such as PDK1, PI3K family members, and mTOR[1].

CC-115 hydrochloride is a potent dual inhibitor of DNA-PK (IC50 = 13 nM) and mTOR kinase (IC50 = 21 nM), effectively blocking both mTORC1 and mTORC2 signaling pathways.