mt 7

MT-7 is a tubulin polymerization inhibitor.

Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values ​​of 8.16, 3.91, 1.14, and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m), and rat (r) MC1R, respectively. Dersimelagon exhibits good affinity for hMC1R and hMC4R, with Ki values ​​of 2.26 and 32.9 nM, respectively. Dersimelagon can be used in the study of skin pigmentation[1].

MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP)

MT-7716 free base is a selective non-peptide agonist of nociceptin receptor (NOP). It is used for promising potential treatment drugs for alcohol abuse and relapse prevention.

SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.

DMT7 is an ionizable cationic lipid (pKa = 6.5) utilized in creating lipid nanoparticles (LNPs) for the delivery of mRNA and anticancer drugs in vivo.

PRMT7-IN-2 (A33) is a selective inhibitor of PRMT7 with an IC50 value of 0.50 μM. It causes cell cycle arrest at the G0/G1 phase, induces apoptosis, and inhibits cell growth both in vivo and in vitro. PRMT7-IN-2 reduces monomethylation levels of arginine by PRMT7, increases the expression of the epithelial marker E-cadherin, and decreases the expression of mesenchymal markers N-cadherin, Vimentin, and ZEB2.

ZLMT-72 is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.741 nM and 1.03 nM, respectively. It shows excellent selectivity in kinase profiling and cholinesterase inhibition activity assays. ZLMT-72 exhibits significant antiproliferative effects on colorectal cancer (CRC) cell line HCT116 (GI50 < 0.1 nM). This compound induces apoptosis by inhibiting the phosphorylation of retinoblastoma protein and RNA polymerase II, leading to the downregulation of anti-apoptotic proteins (Mcl-1 and XIAP). ZLMT-72 is suitable for colorectal cancer (CRC) research.

JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.

PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].

Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients.

Lornoxicam-D4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam (T1468) is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously express COX-2. Lornoxicam (T1468) reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg. Formulations containing lornoxicam have been used in the management of postoperative pain.

MT-7716 HCl hydrate is a NOP receptor agonist.

α-Vitamin E is a naturally occurring form of vitamin E with antioxidant and anti-inflammatory activity. α-Vitamin E can be used in research on oxidative stress, lipid peroxidation, membrane damage, and inflammation-related diseases.

Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.

S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively.

3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50 = 13.4 µM). It is also active against L. donovani amastigotes when used at a concentration of 50 µM.