medulloblastoma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3912	Saikosaponin B1		Others
	Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.		Others
T1267	Abacavir	Epzicom,Ziagen,Abacavir sulfate	Apoptosis , HIV Protease , Reverse Transcriptase
	Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.		Apoptosis , HIV Protease , Reverse Transcriptase
T6367	Abacavir sulfate	Abacavir Hemisulfate,1592U89,ABC sulfate,Ziagen	Apoptosis , HIV Protease , Reverse Transcriptase
	Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity		Apoptosis , HIV Protease , Reverse Transcriptase
T13004	SSTC3		Casein Kinase , Wnt/beta-catenin
	SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.SSTC3 is a potent HIF1α inhibitor with a Kd ...		Casein Kinase , Wnt/beta-catenin
T63429	SMO-IN-2		Hedgehog/Smoothened
	SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c...		Hedgehog/Smoothened
T5465	PF-5274857	PF-5274857 freebase	Smo
	PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t...		Smo
T24423	LY5	LY 5,LY-5
	LY5 is an inhibitor of STAT3 that acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells.
T28388	PF-5274857 mseylate (1373615-35-0 free base)	PF5274857 HCl,PF 5274857,PF-5274857,PF-5274857 mesylate,PF-5274857 mseylate
	PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the b...
T63387	SMO-IN-3
	SMO-IN-3 is a potent inhibitor of smoothened (SMO) that acts on the hedgehog (Hh) signaling pathway (IC50: 34.09 nM). SMO-IN-3 inhibits the proliferation of Daoy, a human medulloblastoma cell line, and exhibits anticance...
T79770	FB49		Autophagy
	FB49 is a selective Bcl-2-associated athanogene 3 (BAG3) inhibitor with a Ki of 45 μM. It inhibits the proliferation of human tumoral cells without affecting the viability of human peripheral mononuclear cells. Additiona...		Autophagy
T71230	VMY-1-103
	VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B...