laxative

D-Sorbitol (Sorbitol) is a polyhydric alcohol with about half the sweetness of sucrose, occurring naturally and also produced synthetically from glucose. Formerly used as a diuretic, it may still be used as a laxative and in irrigating solutions for certain surgical procedures. It is also utilized in various manufacturing processes, as a pharmaceutical aid, and in several research applications.

Casanthranol, a concentrated mixture of anthranol glycosides from the dried bark of Rhamnus p. (cascara sagrada), is a stimulant laxative used to alleviate constipation and other medical conditions by increasing muscle contractions in the intestinal wall to facilitate bowel movements.

Castor oil (Xenaderm) is a vegetable oil pressed from the seeds of the castor bean, Ricinus communis, used as a laxative and as an excipient in medicinally.

Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.

Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.

Sennoside C is an anthraquinone glycoside extracted from leaves and pods of Senna and has an auxiliary effect on the laxative effect of mice.

Aloe-emodin-glucoside is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.

Physcion (Physcione) (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects.

Strictinin, a phenolic compound extracted from Pu'er teas, exhibits antiviral, antibacterial, and laxative properties. Its mode of action involves speeding up intestinal transit without promoting gastric emptying, boosting food consumption, or triggering diarrhea in rats.

Multiflorin A, an active compound extracted from Pruni semen, exhibits laxative properties and hinders intestinal glucose absorption while facilitating bacterial metabolism [1].

Barakol, a primary compound found in Cassia siamea, inhibits MMP-3 activity and enhances the anti-metastatic effects of doxorubicin. Additionally, Barakol induces apoptosis (Apoptosis), generates reactive oxygen species, increases the Bax Bcl-2 expression ratio, and activates caspase-9. This compound also exhibits laxative, anti-anxiety, central nervous system depressant, antioxidant, and anticancer properties.