isoxazole

Isoxazole (1,2-oxazole) is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.

methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.

Biotinylated isoxazole is a biotin-conjugated derivative of isoxazole. It can induce the formation of aggregates associated with RNA granules.

5-Chloro-3-phenylbenzo[c]isoxazole is a useful organic compound for research related to life sciences. The catalog number is T66589 and the CAS number is 719-64-2.

3-Amino-5-methylisoxazole is pharmaceutical intermediates, used in the production of sulfonamide drugs.

Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A.

5-(2-furyl)-N-propylisoxazole-3-carboxamide is a compound used as a molecular structural unit and is thought to be a modulator of NMDA receptors, and has been shown to be protective against glutamate-induced excitotoxicity and oxidative stress in neuronal cells. It has also been found to have anti-inflammatory activity, making it a potential therapeutic agent for diseases such as Alzheimer's disease and Parkinson's disease.

Sulfisoxazole diethanolamine, also known as Sulfafurazole diethanolamine, is a sulfonamide antibacterial compound with an oxazole substituent. It acts as an endothelin receptor antagonist, specifically targeting endothelin receptor A with an IC50 value of 0.60 μM and endothelin receptor B with an IC50 value of 22 μM. Additionally, Sulfisoxazole diethanolamine has been found to inhibit the release of breast cancer exosomes by specifically targeting endothelin receptor A [1] [2].

Pyrisoxazole is a novel fungicide inhibitor of Sterol 14α-demethylase.

5-Methyl-3-phenylisoxazole-4-carbonyl chloride is a useful organic compound for research related to life sciences. The catalog number is T64868 and the CAS number is 16883-16-2.

5-Methyl-3-(2'-chlorophenyl)-4-isoxazolecarboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65275 and the CAS number is 23598-72-3.

5-Methyl-3,4-diphenylisoxazole is a useful organic compound for research related to life sciences. The catalog number is T66198 and the CAS number is 37928-17-9.

3,5-Dimethylisoxazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

5-Methylisoxazole-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66496 and the CAS number is 42831-50-5.

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65267 and the CAS number is 3919-74-2.

Sulfisoxazole acetyl (Gantrisin) is an agent with antibacterial activity. Sulfisoxazole acetyl is a Sulfisoxazole derivative with antibacterial activity. Sulfisoxazole acetyl is an inhibitor of dihydropteroate synthase.

PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociation constant (KD) of 5.43 nM for BRD4(1).

Clomazone (Magister) is an agricultural herbicide. The molecule consists of a 2-chlorobenzyl group bound to an N-O heterocycle called Isoxazole. Clomazone suppresses the biosynthesis of chlorophyll and other plant pigments.

ISX-9 (Isoxazole 9) is essential for activating neuron-specific genes and serves as a neurogenesis inducer.

MK-8245 trifluoroacetate is a phenoxy piperidine isoxazole derivative functioning as a potent, liver-targeting stearoyl-CoA desaturase (SCD) inhibitor, demonstrating significant anti-diabetic and anti-dyslipidemic effects. It showcases high specificity and efficacy against SCD1 across various species, with IC50 values of 1 nM for human SCD1 and 3 nM for both rat and mouse SCD1. MK-8245's mechanism includes a tetrazole acetic acid moiety that facilitates liver-targeting through OATPs recognition. Its inhibition potency in rat hepatocyte assays (IC50 of 68 nM) surpasses that in HepG2 cell assays devoid of active OATPs (IC50 of ~1 μM), highlighting its liver specificity. Moreover, MK-8245 exhibits over 100,000-fold selectivity against Δ-5 and Δ-6 desaturases in comparative assays. In vivo studies reveal MK-8245's preferential liver distribution in mice, rats, dogs, and rhesus monkeys, underscoring its potential for minimizing adverse effects in non-target tissues. Additionally, its administration in eDIO mice before glucose challenges significantly improves glucose clearance, indicating its therapeutic promise in diabetes management.

Sulfacecole is an isoxazole sulfonamide derivative that functions as an antibacterial agent.

VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.

TP748 is a key intermediate for fully synthetic tetracyclines, and is an isoxazole.

Mtb-IN-5 (compound (-)17j) is an isoxazole with anti-Mycobacterium tuberculosis (Mtb) activity, inhibiting Mtb respiration and biofilm formation within macrophages, and enhancing the efficacy of the antibiotic isoniazid (INH) against INH-resistant Mtb mutants [1].