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Search Results for " insulin "

460

Compounds

195

Recombinant Proteins

5

Libraries

Cat No. Product Name
T8221 Insulin (human) INSULIN,Insulin(human) IGF-1R
Insulin (human) is a polypeptide hormone that regulates the level of glucose.
TP1125 Insulin(cattle) Insulin from bovine pancreas IGF-1R
Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in the pancreatic β ce...
T24169 Insulin B (22-30) Insulin (B22-B30)
Insulin B (22-30) is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the m...
T24168 Insulin B (20-30) Insulin (B20-B30)
Insulin B (20-30) is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the m...
TP1621 Insulin alpha-chain (1-13) Insulin alpha-chain 1-13
This peptide is a fragment of the alpha-chain of insulin amino acids 1 to 13. The insulin a-chain epitope recognized by ...
TP1259 [pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) [pTyr1146][pTyr1150][pTyr1151]Insulin Receptor 1142-1153,Insulin Receptor 1142-1153
[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) functions as a substrate for insulin receptor tyrosine kinase...
T11660 Insulin levels modulator COX
Insulin level regulators can be used to treat diabetes.
T40132 Insulin β Chain Peptide (15-23)
Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized ...
T80081 Insulin (swine)
Insulin (swine), a porcine-derived insulin, is utilized in diabetes research [1].
T73706 Insulin glulisine
Insulin glulisine (HMR 1964) is a rapid-acting insulin analogue, it mimics the pharmacokinetic and pharmacodynamic profi...
T73707 Insulin Detemir
Insulin Detemir is an artificial insulin , shows effect on controlling blood sugar levels. Insulin Detemir stimulates GL...
T76540 Insulin peglispro
Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better...
T73688 Insulin glargine
Insulin glargine is a long-acting insulin analog. Insulin glargine can be used for the diabetes mellitus [1] .
TP1122L IGF-I 30-41 acetate(82177-09-1 free base) Insulin-like Growth Factor I (30-41) acetate Others
IGF-I 30-41 acetate(82177-09-1 free base) (Insulin-like Growth Factor I (30-41) acetate) is amino acids 30 to 41 fragmen...
T77037 Insulin efsitora alfa
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR) . Insulin efsitora alfa is a fusion p...
T76539 Insulin-like growth factor II
Insulin-like growth factor II (IGF-2) is the principal somatomedin of human serum. Insulin-like growth factor II exerts ...
TP1126 InsB 9-23 Insulin B chain (9-23)
InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7.
T8773 MID-1 Others , IGF-1R
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular asso...
T21955 GQ-16 PPAR
GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitiza...
T6003 GSK1904529A GSK 4529 Apoptosis , Raf , VEGFR , IGF-1R , Syk
GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
1 2 3 4 5 ... 23
Cat No. Product Name Species Source
TMPY-00395 Insulin Protein, Human, Recombinant Human Yeast
INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with ...
TMPY-01146 Insulin Receptor Protein, Human, Recombinant (long isoform, His) Human HEK293
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding ...
TMPY-04395 Insulin Receptor Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding ...
TMPY-01149 Insulin Receptor Protein, Human, Recombinant (short isoform, His) Human HEK293
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding ...
TMPY-05283 Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated Human HEK293
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding ...
TMPY-04508 IGFBP-7 Protein, Mouse, Recombinant (hFc,Met1-Leu281) Mouse HEK293
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have bee...
TMPY-00835 IGFBP-3 Protein, Human, Recombinant (His) Human HEK293
The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been...
TMPY-00834 IGF1R Protein, Human, Recombinant (His) Human HEK293
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. The IGF1R signaling pathway is...
TMPY-02295 IGFBP-7 Protein, Human, Recombinant (hFc,Met 1-Leu 282) Human HEK293
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have bee...
TMPY-05014 INSL6 Protein, Human, Recombinant (His) Human HEK293
INSL6 (Insulin-Like 6) is a Protein Coding gene. An important paralog of this gene is RLN1. The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. INSL6 is a newly identified insulin/relaxin family peptide hormone that is predominantly expressed by the male germ cells in testes. It may have a role in sperm development and fertilization. A recent murine study demonstrated that INSL6-knockout resul...
TMPJ-00577 INSL3 Protein, Human, Recombinant (His) Human Human Cells
Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene. It is a secreted protein that belongs to the insulin family. It is expressed in prenatal and postnatal Leydig cells and found as well in the corpus luteum, trophoblast, fetal membranes and breast. It may act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent.It is a ligand for LGR8 receptor.
TMPJ-00851 IDE Protein, Human, Recombinant (His) Human Human Cells
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted...
TMPY-00471 INSL4 Protein, Human, Recombinant (His) Human HEK293
INSL4 (Insulin-Like 4) is a Protein Coding gene. An important paralog of this gene is RLN1. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains or just the A and B chains. INSL4 is a member of the insulin family, which includes insulin, IGF-I, IGF-II, relaxin, and INSL3.INSL4 distribution was tissue- and cell-specific. Indeed, INSL4 mRNA was most abundant in syncytiotrophoblas...
TMPY-04513 IGFBP-6 Protein, Rat, Recombinant (His) Rat HEK293
Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) bindin...
TMPY-00080 IGFBP-1 Protein, Canine, Recombinant (His) Canine HEK293
IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of th...
TMPY-03249 IGFBP-4 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Insulin-like growth factor-binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) bindi...
TMPY-02920 IGFBP-1 Protein, Rhesus, Recombinant (His) Rhesus HEK293
IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of th...
TMPY-03251 IGFBP-3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been...
TMPY-00508 IGFBP-5 Protein, Canine, Recombinant (hFc) Canine HEK293
TMPJ-00781 LR3-IGF-1 Protein, Mouse, Recombinant (His) Mouse E. coli
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IG...

Recombinant Proteins

Insulin Protein, Human, Recombinant
TMPY-00395
Species: Human
Source: Yeast
Insulin Receptor Protein, Human, Recombinant (long isoform, His)
TMPY-01146
Species: Human
Source: HEK293
Insulin Receptor Protein, Human, Recombinant (His & GST)
TMPY-04395
Species: Human
Source: Baculovirus-Insect Cells
Insulin Receptor Protein, Human, Recombinant (short isoform, His)
TMPY-01149
Species: Human
Source: HEK293
Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated
TMPY-05283
Species: Human
Source: HEK293
IGFBP-7 Protein, Mouse, Recombinant (hFc,Met1-Leu281)
TMPY-04508
Species: Mouse
Source: HEK293
IGFBP-3 Protein, Human, Recombinant (His)
TMPY-00835
Species: Human
Source: HEK293
IGF1R Protein, Human, Recombinant (His)
TMPY-00834
Species: Human
Source: HEK293
IGFBP-7 Protein, Human, Recombinant (hFc,Met 1-Leu 282)
TMPY-02295
Species: Human
Source: HEK293
INSL6 Protein, Human, Recombinant (His)
TMPY-05014
Species: Human
Source: HEK293
INSL3 Protein, Human, Recombinant (His)
TMPJ-00577
Species: Human
Source: Human Cells
IDE Protein, Human, Recombinant (His)
TMPJ-00851
Species: Human
Source: Human Cells
INSL4 Protein, Human, Recombinant (His)
TMPY-00471
Species: Human
Source: HEK293
IGFBP-6 Protein, Rat, Recombinant (His)
TMPY-04513
Species: Rat
Source: HEK293
IGFBP-1 Protein, Canine, Recombinant (His)
TMPY-00080
Species: Canine
Source: HEK293
IGFBP-4 Protein, Cynomolgus, Recombinant (His)
TMPY-03249
Species: Cynomolgus
Source: HEK293
IGFBP-1 Protein, Rhesus, Recombinant (His)
TMPY-02920
Species: Rhesus
Source: HEK293
IGFBP-3 Protein, Cynomolgus, Recombinant (His)
TMPY-03251
Species: Cynomolgus
Source: HEK293
IGFBP-5 Protein, Canine, Recombinant (hFc)
TMPY-00508
Species: Canine
Source: HEK293
LR3-IGF-1 Protein, Mouse, Recombinant (His)
TMPJ-00781
Species: Mouse
Source: E. coli
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TargetMol