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  • Imidazoline Receptor
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Results for "

i1-imidazoline receptor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    7
    TargetMol | Inhibitors_Agonists
  • Natural Products
    1
    TargetMol | Natural_Products
harman hydrochloride
Harmane hydrochloride(486-84-0 Free base)
T3158L21655-84-5
Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenicity, co-mutagenicity and carcinogenicity.
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TargetMol | Inhibitor Sale
Rilmenidine Phosphate
T664185409-38-7
Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.
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TargetMol | Inhibitor Sale
Idazoxan
RACEMIC IDAZOXAN, DL-IDAZOXAN, (±)-IDAZOXAN
T20205579944-58-4
Idazoxan is an alpha2 receptor antagonist that also exhibits activity at imidazoline [I1] and [I2] receptors, playing a role in modulating dopamine release.
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Rilmenidine hemifumarate
Rilmenidine (hemifumarate), S-3341 hemifumarate
T21911207572-68-7
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.
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1-2 weeks
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Dexisometheptene
TNX 201,TNX-201,(R)-Isometheptene,TNX201
T271551620401-56-0
Dexisometheptene is an antimigraine drug candidate. Dexisometheptene significantly increases the pain threshold of acute pain response, and potently and selectively binds to receptors in the central nervous system known as imidazoline type-1 (I1) receptor
    6-8 weeks
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    Harmane
    Loturine, Harman, Aribine
    T3158486-84-0
    Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.
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    Moxonidine hydrochloride
    BDF5895hydrochloride
    T4086975536-04-8
    Moxonidine Hydrochloride serves as a selective agonist for the imidazoline receptor subtype 1 and functions as an antihypertensive agent. It primarily acts within the central nervous system and demonstrates a significant preference for I1 imidazoline receptors over α2-adrenoceptors, with a 40-fold higher affinity. This compound effectively reduces stimulated norepinephrine overflow, indicating its potent efficacy. Despite similar agents like AGN192403 targeting the same receptor, moxonidine's dose-response efficacy remains unaffected. Its ability to lower blood pressure and reduce heart rate is distinctly mediated through imidazoline receptors, reliant on well-preserved noradrenergic pathways within the rostral ventrolateral medulla (RVLM). This interaction is potentially linked to a specific 42 kDa imidazoline receptor protein, emphasizing its unique mechanism of action compared to other drugs like clonidine.
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