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NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .

5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.

Shikimic Acid (Shikimate) is a tri-hydroxy cyclohexene carboxylic acid important in the biosynthesis of so many compounds that the shikimate pathway is named after it.

Chikusetsusaponin IVa (Calenduloside F) is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used in T2DM patients.

CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effective Chikungunya virus (CHIKV) inhibitor, demonstrating significant cellular antiviral activity (EC90=270 nM) and enhanced liver microsomal stability[1].

(+)-Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. (+)-Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.

3,5-Di-O-galloylshikimic acid is a useful organic compound for research related to life sciences. The catalog number is T123852 and the CAS number is 95753-52-9.

3,4-Di-o-galloylshikimicacid is a useful organic compound for research related to life sciences. The catalog number is T123853 and the CAS number is 95753-51-8.

Chikusetsusaponin V methyl ester is a useful organic compound for research related to life sciences and the catalog number is T125004.

Shikokianin is a useful organic compound for research related to life sciences and the catalog number is T125224.

Dihydroyashabushiketol is a useful organic compound for research related to life sciences. The catalog number is T125228 and the CAS number is 24192-01-6.

Yashabushiketol is a useful organic compound for research related to life sciences. The catalog number is T125229 and the CAS number is 24192-00-5.

3-O-Caffeoylshikimic acid is a useful organic compound for research related to life sciences and the catalog number is T125535.

5-0-Galloylshikimicacid is a useful organic compound for research related to life sciences. The catalog number is T126409 and the CAS number is 110082-91-2.

Compound TCFN95222 is a useful organic compound for research related to life sciences. The catalog number is T131720 and the CAS number is 52387-14-1.

PhiKan 083 hydrochloride, a carbazole derivative, binds to the surface cavity and stabilizes Y220C (Kd: 167 μM) with a relative binding affinity (Kd) of 150 μM in Ln229 cells.

PhiKan 083, a carbazole derivative, exhibits potential as an eco-friendly dye with applications in the development of organic photovoltaic cells (OPVs).

CHIKV nsP2 protease-IN-1 (compound J13) is an orally active inhibitor of non-structural protein 2 protease (non-structural protein 2protease), exhibiting an EC50 value of 0.39 μM against CH S27. This compound is utilized in the research of Chikungunya virus.

CHIKV-IN-5 (Compound 26) is an inhibitor of CHIKV with an EC90 value of 0.45 μM. It suppresses the replication of CHIKV in the later stages of the viral life cycle by blocking the translation of structural proteins. CHIKV-IN-5 demonstrates high stability in vitro within mouse microsomes. In infected mice, it alleviates footpad swelling and reduces the spread of the virus to other tissues.

Signal enhancer for use in western blotting, dot blotting and ELISA

(Rac)-Shikonin (Anchusin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.

Hikizimycin, a potent anthelmintic and antibacterial natural product, exhibits significant efficacy against parasitic worms and bacterial infections.

1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.

1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors. 2. Acetylshikonin inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated. 3. Certain shikonin derivatives(such as Acetylshikonin) act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction. 4. Acetylshikonin, shikonin, and alkannin have accelerative effect on the proliferation of granulation tissue in rats. 5. Acetylshikonin has inhibitory effect on the edematous response is due neither to the release of steroid hormones from the adrenal gland nor to the glucocorticoid activity, but probably partly to the suppression of mast cell degranulation and partly to protection of the vasculature from mediator challenge. 6. Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.