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Search Results for " hemolytic "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9189	Iptacopan hydrochloride	Iptacopan HCl,LNP023 hydrochloride	Complement System
	Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity b...		Complement System
T13041	Surfactin		HSV
	Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with anti-bacterial, anti-fungal, antimycoplasma and hemolytic eff...		HSV
TP1018L	Urechistachykinin II acetate	Urechistachykinin II acetate(149097-04-1 free base),Uru-TK II acetate	Others
	Urechistachykinin II acetate (Uru-TK II acetate) is an invertebrate rapid kinin-related peptide (TRPs) isolated from carotenoid worms, shows antimicrobial activities without a hemolytic effect		Others
T1386	Phenazopyridine hydrochloride	Urodine,Pyridium,Phenazopyridine HCl	Sodium Channel
	Phenazopyridine hydrochloride (Pyridium) is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the oxygen-carrying capacity of red...		Sodium Channel
T76867	Ravulizumab	ALXN1210	Complement System
	Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo...		Complement System
T8509	Danicopan	ACH-4471	Complement System
	Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ...		Complement System
T25702	Levovirin	ICN 17261,L-Ribavirin,ICN-17261,ICN17261
	Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin. Levovirin has similar immunomodulatory activity but does not have direct antiviral activity or h...
T79468	Antimicrobial agent-22
	Antimicrobial agent-22 (THI 6c) constitutes a broad-spectrum, multi-target antibacterial with notable rapid bactericidal efficacy and effective anti-biofilm activity, paired with low cytotoxicity and hemolytic properties...
T80394	Des(8-14)brevinin-1PMa
	Des(8-14)brevinin-1PMa is a host-defense peptide known for its potent antimicrobial properties, particularly against Staphylococcus aureus and Echerichia coli. Additionally, this compound demonstrates hemolytic activity ...
T81514	Peptide 5f
	Peptide 5f, sourced from wasp venom, exhibits antimicrobial properties effective against both bacterial and fungal pathogens, while demonstrating minimal hemolytic activity on human red blood cells [1].
T16992	Taribavirin hydrochloride		Others
	Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distr...		Others
T80373	Maximin 77
	Maximin 77 is an antimicrobial peptide with antibacterial activity against S. aureus (MIC: 18.8 μg/mL) and exhibits hemolytic activities against human red cells [1].
T38259	Phenelfamycin E
	Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) inc...
T80398	Brevinin-1PMa
	Brevinin-1PMa is a host-defense peptide with antimicrobial properties effective against both Staphylococcus aureus and Escherichia coli, as well as demonstrated hemolytic activity [1].
T80370	Maximin 42
	Maximin 42 is an antimicrobial peptide with antibacterial activity against S. aureus (MIC: 37.5 μg/mL) and exhibits hemolytic activities against human red cells [1].
T75582	Naja Melanoleuca Venom
	Naja Melanoleuca Venom (Forest Cobra Venom) is a snake venom derived from Naja Melanoleuca, exhibiting hemolytic activity against human erythrocytes. It contains α-neurotoxins that isolate from the venom and inhibit the ...
T80366	Maximin 49
	Maximin 49, an antimicrobial peptide, exhibits antibacterial activity against S. aureus (MIC: 18.8 μg/mL) and demonstrates hemolytic activities on human and rabbit red cells [1].
T80363	Maximin 41
	Maximin 41, an antimicrobial peptide, exhibits antibacterial activity against S. aureus with a minimum inhibitory concentration (MIC) of 75 μg/mL and demonstrates hemolytic activities against human red cells [1].
T16993	Taribavirin		Others
	Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cel...		Others
T63552	FtsZ-IN-1
	FtsZ-IN-1 is a potent FtsZ inhibitor with a quinoline ring and has a strong inhibitory effect on Gram-positive bacteria (MIC: 0.5-8 μg/mL).FtsZ-IN-1 enhances FtsZ polymerization and significantly promotes cell elongation...
T80368	Im5
	Im5, an antimicrobial peptide, exhibits antibacterial activity, with minimum inhibitory concentrations (MIC) of 10 μM for E. coli, 2.5-5 μM for S. aureus, and 0.5-1 μM for B. subtilis, as well as hemolytic activity with ...
T74527	Anti-MRSA agent 4
	Anti-MRSA agent 4 (compound 7a), a selective and potent inhibitor of Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA) growth, demonstrates a minimum inhibitory concentration (MIC) of ≤ 0.26 µM. It exhibit...
T76570	PSM-β
	PSM-β, an active peptide isolated from Staphylococcus epidermidis, acts as an analog of staphylococcal toxins and is also known as a phenol-soluble modulin (PSM). PSM-β exhibits bacteriostatic properties and possesses mi...
T80365	Maximin H39
	Maximin H39, an antimicrobial peptide, exhibits antibacterial activity against C. albicans, S. aureus, and B. subtilis with minimum inhibitory concentrations (MIC) of 9.4, 9.4, and 18.8 μg/mL, respectively. It also demon...
T80369	Maximin 68
	Maximin 68, an antimicrobial peptide, exhibits antibacterial activity against C. albicans, S. aureus, E. coli, and B. subtilis, with MIC values of 18.8, 9.4, 37.5, and 9.4 μg/mL, respectively. It also possesses hemolytic...
T80139	CRAMP-18 (mouse)		Antibiotic
	CRAMP-18 (mouse) is an antibiotic peptide with demonstrated efficacy against Gram-negative bacteria, including S. typhimurium and P. aeruginosa, while exhibiting no hemolytic activity. This compound shows promise for res...		Antibiotic
T80364	Maximin 45
	Maximin 45, an antimicrobial peptide, exhibits antibacterial activity against S. aureus, E. coli, and B. subtilis with minimum inhibitory concentrations (MIC) of 4.7, 9.4, and 75 μg/mL, respectively. Additionally, it pos...
T71266	Omadacycline HCl
	Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant S...
T78914	S-F24
	S-F24 is a broad-spectrum antifungal agent that demonstrates potent inhibition of CYP3A4, with an IC50 of 0.4 μM. It exhibits a favorable safety profile, characterized by high selectivity, minimal hemolytic effects, and ...
T73127	C16-K-cBB1
	C16-K-cBB1 is a potent, selective antimicrobial agent effective against Methicillin-resistant Staphylococcus aureus (MRSA), demonstrated by its minimal inhibitory concentration (MIC) of 1 µg/mL. This compound exhibits ex...
T74553	YSK 05
	YSK 05, a pH-sensitive cationic lipid, enhances the intracellular trafficking of non-viral vectors, significantly improves gene silencing and hemolytic activities in its modified form YSK 05-MEND, and effectively overcom...
T76468	Cecropin A (1-7)-Melittin A (2-9)
	Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide that exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative aerobic bacteria, in addition to antimalarial properties. Not...
T80367	Maximin 78
	Maximin 78 is an antimicrobial peptide with antibacterial activity against C. albicans, S. aureus, and B. subtilis, exhibiting minimum inhibitory concentrations (MIC) of 37.5, 4.7, and 37.5 μg/mL, respectively. Additiona...
T78935	Quorum Sensing-IN-2
	Quorum Sensing-IN-2 (compound 23e) is a quorum sensing inhibitor that curtails bacterial pathogenicity without impeding growth. It demonstrates minimal hemolytic activity while effectively inhibiting bacterial infections...
T74788	FtsZ-IN-5
	FtsZ-IN-5 is a potent inhibitor of FtsZ, promoting polymerization while inhibiting its GTPase activity, thereby preventing bacterial division and leading to cell death. It exhibits bactericidal activity without significa...
T74790	FtsZ-IN-7
	FtsZ-IN-7 is a potent inhibitor of FtsZ, enhancing FtsZ polymerization while inhibiting its GTPase activity, therefore disrupting bacterial cell division and culminating in bacterial cell death. It exhibits bactericidal ...
T80378	Tilapia piscidin 3
	Tilapia piscidin 3, an antimicrobial peptide, exhibits antibacterial properties effective against both gram-positive and gram-negative bacteria. It has demonstrated minimum inhibitory concentrations (MICs) of 2.44 µg/mL ...
T80252	BMAP-18
	BMAP-18 is a biologically active peptide, a truncated derivative of BMAP-27, which is part of the Cathelicidin family of peptides known for their potent bactericidal properties against pathogens such as Staphylococcus au...
T80262	SMAP-18
	SMAP-18, an 18-amino acid residue peptide amide, is a biologically active truncated variant of Sheep myeloid antimicrobial peptide-29 (SMAP-29). It retains potent antimicrobial activity against Pseudomonas strains, other...
T74789	FtsZ-IN-6
	FtsZ-IN-6 is a potent inhibitor of FtsZ, enhancing its polymerization while inhibiting its GTPase activity, thereby obstructing bacterial cell division and causing bacterial cell death. This compound exhibits bactericida...
T74791	FtsZ-IN-8
	FtsZ-IN-8, a potent inhibitor of FtsZ, both promotes FtsZ polymerization and inhibits its GTPase activity, leading to the inhibition of bacterial division and subsequent bacterial cell death. This compound exhibits bacte...
T82474	Empasiprubart	ARGX-117
	Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. It inhibits the formation of C3 proconvertase, obstructing classical and lectin pathway activation by binding to the Sushi-2...
T80286	TP4 (Nile tilapia piscidin)		Necroptosis
	TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial strains with a minimum inhibitory concentration (MIC) ranging f...		Necroptosis
T37873	CAP 3
	CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increas...

Compounds

Iptacopan hydrochloride

T9189

Synonym: Iptacopan HCl,LNP023 hydrochloride

Target: Complement System

Urechistachykinin II acetate

TP1018L

Synonym: Urechistachykinin II acetate(149097-04-1 free base),Uru-TK II acetate

Target: Others

Phenazopyridine hydrochloride

T1386

Synonym: Urodine,Pyridium,Phenazopyridine HCl

Target: Sodium Channel

Ravulizumab

T76867

Synonym: ALXN1210

Target: Complement System

Danicopan

T8509

Synonym: ACH-4471

Target: Complement System

Levovirin

T25702

Synonym: ICN 17261,L-Ribavirin,ICN-17261,ICN17261

Target:

Antimicrobial agent-22

T79468

Synonym:

Target:

Des(8-14)brevinin-1PMa

Taribavirin hydrochloride

Naja Melanoleuca Venom

Cecropin A (1-7)-Melittin A (2-9)

TP4 (Nile tilapia piscidin)

Cat No.	Product Name	Synonyms	Targets
TN6864	Prosaikogenin F	(2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol	Others
	Prosaikogenin F ((2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3...		Others
TN2088	Platycodin D2		IL Receptor , HBV
	Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalaci...		IL Receptor , HBV
T3368	Alpha-Hederin	Helixin,Tauroside E,α-Hederin,Hederoside C	Apoptosis , Others
	Alpha-Hederin (Tauroside E) is a water-soluble pentacyclic triterpenoid saponin found in the seeds of Nigella sativa, with hemolytic and apoptotic properties.		Apoptosis , Others
T3891	Oroxylin A-7-O-glucuronide	Oroxylin A Glucoronide,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide	Others
	Oroxylin A-7-O-glucuronide (Oroxylin A Glucoronide) and wogonoside should also be served as the chemical markers together with baicalin for the quality control of herbs and proprietary traditional Chinese medicine (PTCM)...		Others
T41138	Prosaikogenin H
	Prosaikogenin H, an intestinal metabolite derived from saikosaponin, exhibits weak hemolytic activity.
TN4804	Platycoside A		Antifection
	Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mi...		Antifection
TN5930	Ocotillone
	Ocotillone has potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that are without hemolytic activity, whereas it has weak antimicrobial activity against Gram-positive bacteri...
T76129	Hemocyanin
	Hemocyanin, a substantial copper-bearing respiratory protein, serves as a crucial molecule in non-specific innate immune defense, exhibiting phenoloxidase, antiviral, antibacterial, hemolytic, and antitumor activities [1...
T36439	Gramicidin A		Antibacterial , HIF , Parasite
	Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t...		Antibacterial , HIF , Parasite

Natural Products

Prosaikogenin F

TN6864

Synonym: (2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol

Target: IL Receptor, HBV

Alpha-Hederin

T3368

Synonym: Helixin,Tauroside E,α-Hederin,Hederoside C

Target: Apoptosis, Others

Oroxylin A-7-O-glucuronide

T3891

Synonym: Oroxylin A Glucoronide,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide

Target: Antibacterial, HIF, Parasite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01075	Von Willebrand Factor/vWF Protein, Human, Recombinant (His)	Human	CHO
	Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vasc...
TMPH-00512	Lysenin-related protein 2 Protein, Eisenia foetida, Recombinant (His & Myc)	Eisenia fetida	E. coli
	Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. It also has antibacterial activities against B.megaterium.
TMPH-00636	Hemolysin E, chromosomal Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells.
TMPH-03554	HlgB Protein, S. aureus, Recombinant (E. coli, His)	Staphylococcus aureus	E. coli
	Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03555	HlgB Protein, S. aureus, Recombinant (His)	Staphylococcus aureus	Yeast
	Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03557	HlgC Protein, S. aureus, Recombinant (His)	Staphylococcus aureus	Yeast
	Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03553	HlgA Protein, S. aureus, Recombinant (His & Myc)	Staphylococcus aureus	E. coli
	Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03556	HlgC Protein, S. aureus, Recombinant (E. coli, His)	Staphylococcus aureus	E. coli
	Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPY-04765	PKLR Protein, Human, Recombinant (His)	Human	E. coli
	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat...
TMPJ-01306	CFHR5 Protein, Human, Recombinant (His)	Human	Human Cells
	Complement factor H-related protein 5(FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other...
TMPH-00037	Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His)	Aggregatibacter actinomycetemcomitans	Yeast
	Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably ...
TMPJ-01034	TIM Protein, Human, Recombinant (His)	Human	E. coli
	Triose-phosphate isomerase, also named Triose-phosphate isomerase, TPI and TIM, is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3...
TMPH-03035	M-myrmeciitoxin-Mp2b Protein, Myrmecia pilosula, Recombinant (GST & His)	Myrmecia pilosula	Baculovirus
	Heterodimer protein that may serve both defensive (pain-inducing) and predatory (insecticidal) roles. Has membrane-disrupting activity and shows induction of non-specific calcium influx into cells,. Shows broad-spectrum ...
TMPH-02174	PYCR1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli

TMPH-02414	Lys-gingipain W83 Protein, Porphyromonas gingivalis, Recombinant (His)	Porphyromonas gingivalis	E. coli
	Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the fun...
TMPH-00387	Toxin CfTX-1 Protein, Chironex fleckeri, Recombinant (His & SUMO)	Chironex fleckeri	E. coli
	May cause profound effects on the cardiovascular system of anesthetized rats (at 25 ug/kg), since the fraction containing this toxin and CfTX-2 produces an initial increase in mean arterial pressure, followed by cardiova...
TMPJ-00800	BPGM Protein, Human, Recombinant (His)	Human	E. coli
	Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,...
TMPH-00511	Lysenin Protein, Eisenia fetida, Recombinant (His)	Eisenia fetida	E. coli
	Pore-forming toxin that defensively acts against parasitic microorganisms by forming pores in sphingomyelin-containing membranes. Has hemolytic activity and is also cytotoxic to spermatozoa of some species of invertebrat...
TMPY-02023	CD46 Protein, Human, Recombinant (His)	Human	HEK293
	CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white bloo...
TMPY-03271	Thrombomodulin Protein, Rat, Recombinant (His)	Rat	HEK293
	Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the ...
TMPJ-00836	G6PD Protein, Human, Recombinant (His)	Human	Human Cells
	Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by ...
TMPJ-00979	GSH-S Protein, Human, Recombinant (His)	Human	E. coli
	Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glyci...
TMPY-05829	Thrombomodulin Protein, Human, Recombinant (His)	Human	HEK293
	Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the ...
TMPY-02835	DEFB103A Protein, Human, Recombinant (His)	Human	E. coli
	Beta-defensin 3 is a member of the defensin family. Defensin family is comprised by microbicidal and cytotoxic peptides made by neutrophils. Members of the beta-defensin 3 family are highly similar in protein sequence. B...
TMPY-04129	Complement factor H/CFH Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens...
TMPY-04141	Complement factor H/CFH Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens...