gemcitabine

Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.

R306465 is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro.

Gemcitabine elaidate (CP-4126) hydrochloride is a lipophilic pro-drug of Gemcitabine, converted to Gemcitabine by esterases for phosphorylation. Unlike gemcitabine, Gemcitabine elaidate hydrochloride can be administered orally, displaying schedule and dose-dependent toxicity and antitumor activity.

Gemcitabine-O-Si(di-iso)-O-Mc, a drug-linker conjugate for Antibody-Drug Conjugates (ADC), exhibits potent antitumor activity. It incorporates Gemcitabine, a pyrimidine nucleoside analog antimetabolite and antineoplastic agent, connected through the ADC linker [1].

Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.

Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.

LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.

dFdCTP trisodium (Gemcitabine triphosphate trisodium) is a Gemcitabine derivative that is cytotoxic and inhibits processes required for DNA synthesis. dFdCTP trisodium inhibits T-araCTP and araCTP, which dopes DNA and terminates DNA Inhibits T-araCTP and araCTP.

Mc-O-Si(di-iso)-O-Gemcitabine is a thiol-reactive Drug-linker that can be used in the synthesis of antibody-drug conjugates (ADCs).

Gemcitabine triphosphate (dFdCTP), alongside its counterpart, the active diphosphate (dFdCDP), represents one of the two primary nucleoside metabolites of Gemcitabine within cellular structures. It serves as a benchmark in radiolabeled probe imaging investigations aimed at pinpointing tumors responsive to Gemcitabine. Furthermore, it is instrumental in assessing the compound's absorption and retention by cells [1] [2].

(2S)-Gemcitabine-13C,15N2 (hydrochloride) is the isotopically labeled version of (2S)-Gemcitabine hydrochloride, utilizing both 13C and 15N.

MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate that forms part of the antibody-antibiotic conjugate (AAC) molecule. It is synthesized by conjugating the linker with the antibiotic Gemcitabine. This compound is useful in studying the immunotherapy of bacterial infections and developing novel antibacterial drugs.

1'-epiGemcitabine hydrochloride is an isomer of Gemcitabine hydrochloride and can be used as a control compound in experiments. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a nucleoside antimetabolite/analog and an antineoplastic agent. Gemcitabine hinders DNA synthesis and repair, causing autophagy and apoptosis.

Gemcitabine-13C,15N2(hydrochloride) is the 13C and 15N labeled version of Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) functions as a nucleoside antimetabolite analog and antineoplastic agent. It interrupts DNA synthesis and repair, which leads to autophagy and apoptosis in cells.

Gemcitabine (Standard) is a reference standard for research and analysis in studies involving Gemcitabine. Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.

Gemcitabine EP Impurity C-13C-15N2 is the 13C and 15N labeled compound of Gemcitabine EP Impurity C.

AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.

2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC).

Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an orally active and highly efficient ATP-competitive ALK5 (activin receptor-like kinase 5) inhibitor, a TGF-β receptor I inhibitor with anti-metastatic and anticancer properties. It sensitizes pancreatic cancer cells to gemcitabine by inhibiting their viability.

RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog. RX-3117 displays anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.

Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator. It can be used in cancer treatment to make tumor cells more sensitive to radiation therapy. THU is a competitive cytidine deaminase(CDA) inhibitor that inhibits deamination in the catabolism of cytotoxic deoxycytidine analogs such as ara-C and Gemcitabine.

Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.

Mc-O-Si(di-iso)-Cl is a cleavable ADC linker, frequently used in the synthesis of antibody-drug conjugates (ADCs) such as Gemcitabine-O-Si(di-iso)-O-Mc [1].