ganoderic acid a

1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis and suppression of invasion in human

Ganoderic acid AM1 treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.8+/-0.7 microM.

20-Hydroxyganoderic acid A is a triterpene compound identified in Ganoderma lucidum. This compound may exhibit anti-inflammatory properties, suggesting its potential application in the research of inflammatory diseases.

Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidases (NAs), particularly H1N1 and H5N1 neuraminidases, with IC50 values of 4.6 and 10.9 μM, respectively.

Ganoderic acid M is a useful organic compound for research related to life sciences and the catalog number is T126539.

Ganoderic acid J, a natural terpenoid extracted from Ganoderma lucidum fungus, exhibits anti-inflammatory properties.

Ganoderic acid ε, a naturally occurring terpenoid, is extracted from the Fungus Ganoderma lucidum. This compound possesses an ED 50 value of 12.2 μg mL, as demonstrated in its impact on Meth-A tumor cells.

Ganoderic acid R, exhibiting notable anticancer properties, effectively hampers tumor growth through apoptosis induction in both multidrug resistance (MDR) tumor cell line (KB-A-1 Dox) and sensitive tumor cell line (KB-A-1), demonstrating significant cytotoxicity.

Ganoderic acid Df, a lanostane-type triterpenoid isolated from the fruiting body of Ganoderma lucidum, potently inhibits aldose reductase with an IC 50 of 22.8 ± 0.6 μM [1].

Ganoderic acid Mk (GA-Mk), a triterpenoid acid derived from Ganoderma lucidum mycelia, exhibits potent anti-proliferative properties and can induce apoptosis in HeLa cells through a mitochondria-mediated pathway, making it significant for cervical cancer research [1] [2].

Ganoderic acid Mf, an antitumor triterpenoid, selectively induces apoptosis in cancer cells through a mitochondria-mediated pathway while demonstrating high selectivity between normal and cancer cells. It also arrests the cell cycle in the G1 phase [1].

Ganorbiformin B, a lanostane triterpenoid, belongs to the same structural class as ganoderic acids, sharing the lanostane skeleton. It is the C-3 epimer of ganoderic acid T, known for its potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra [1].

Ganoderic acid T1, a deacetylated derivative of Ganoderic acid T, diminishes mitochondrial membrane potential and triggers cell apoptosis by activating caspase-9 and caspase-3, thus impairing the antioxidant defense system of cancer cells. Additionally, it elevates intracellular ROS levels, yielding pro-oxidant activities and cytotoxicity [1].

Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1].

Ganoderic acid T, a natural compound isolated from Ganoderma lucidum [1], exhibits various pharmacological properties.

Ganoderic acid Me, a triterpenoid present in Ganoderma lucidum [1], exhibits various biological activities.

A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca

Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards therapeutic window of trifluoperazine.Ganoderic acid B has antinociceptive effect

23S-hydroxy-11,15-dioxo-ganoderic acid DM is a natural product

Deacetyl ganoderic acid F (DeGA F), a triterpenoid extracted from Ganoderma lucidum, inhibits lipopolysaccharide (LPS)-induced inflammation in vitro and in vivo.

The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol.

Ganoderic acid D2 is a natural product

Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4.

Ganoderic acid I is a natural product from Ganoderma lucidum .