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Search Result

Search Results for " ergosterol "

37

Compounds

15

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T37858 Dehydroergosterol 9,11-dehydro Ergosterol,DHE
Dehydroergosterol is a naturally occurring, fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes.[1] It is readily bound by cholesterol-binding proteins and h...
T8490 Butoconazole 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole Antifungal
Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent
T20625 Prochloraz Sporgon,Prelude Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and...
T2305 Isavuconazole BAL-4815,RO-0094815 P450 , Antibiotic , Antifungal
Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabr...
T19721 Epoxiconazole BAS-480F,BAS 480F,EC 406 850 2,BAS480F,EC-406-850-2 Antifungal
Epoxiconazole (BAS-480F) is a 14-α demethylase inhibitor. It inhibits ergosterol synthesis and fungal cell wall formation.
T124072 9,11-Dehydroergosterol peroxide
9,11-Dehydroergosterol peroxide is a useful organic compound for research related to life sciences. The catalog number is T124072 and the CAS number is 86363-50-0.
T2199 Myclobutanil Systhane Antifungal
Myclobutanil (Systhane) is a triazole chemical used as a fungicide. It is a steroid demethylation inhibitor, specifically inhibiting ergosterol biosynthesis. Ergosterol is a critical component of fungal cell membranes.
T0187 Amorolfine hydrochloride Amorolfin,Amorolfine HCl,Ro 14-4767/002 Antibiotic , Antifungal
Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function an...
T6686 Sulconazole mononitrate Exelderm,Sulconazole Nitrate,RS 44872 Antibacterial , Antibiotic , Antifungal
Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demeth...
T1187 Bifonazole Bay H-4502 P450 , Antibiotic , Antifungal
Bifonazole (Bay H-4502) acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a substance called ergosterol, which is an essent...
T3934 Isavuconazonium sulfate Antifungal
Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh...
T7866 Difenoconazole Others , Antifungal
Difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell ...
T2213 Terconazole Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,R42470 Antifection , Antifungal
Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damag...
T5966 Hexaconazole (-)-Hexaconazol Reactive Oxygen Species , Antifungal
Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of ...
T1497 Liranaftate Piritetrate,M-732 Antifungal
Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity. Liranaftate inhibits fungal squalene epoxidase, an enzyme that plays a key role in the synthesis of sterol which is ...
T35353 Elubiol dichlorophenyl imidazoldioxolan Antibacterial
Elubiol (dichlorophenyl imidazoldioxolan) is a new broad-spectrum antifungal product of imidazole, which can inhibit the biosynthesis of fungal ergosterol and change the composition of other lipid compounds in the cell m...
T1438 Butoconazole nitrate RS 35887 Estrogen/progestogen Receptor , Antifungal
Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversi...
T1543 Naftifine hydrochloride Naftifungin,Naftifine HCl,Naftin,Exoderil Hedgehog/Smoothened , Antibiotic , Antifungal
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its...
T1290 Oxiconazole nitrate Ro 13-8996 Others , Antibiotic , Antifection , Antifungal
Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole...
T28914 Tak 187 Tak-187,Tak187
Tak 187 is a long-lasting inhibitor of ergosterol biosynthesis.
T71341 Myclobutanil hydroxide
Myclobutanil hydroxide is a 14-α demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. It also weakly inhibits testosterone production.
T15708 Lanoconazole Antifungal
Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alph...
T34924 Triadimenol Spinnaker,UK199,Baytan,UK 199,UK-199
Triadimenol is a systemic fungicide with a broad spectrum. It inhibits the ergosterol - and gibberellin - biosynthesis, and thus the rate of cell division.
T21365 Butenafine KP363,KP 363,Mentax,KP-363,Butop
Butenafine hydrochloride is a hydrochloride of butenafine, which inhibits squalene epoxidase to inhibit the synthesis of ergosterol, leading to the increased permeability of the cell membranes, allowing their contents to...
T6702L Terbinafine lactate DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT
Terbinafine, a synthetic allylamine antifungal, inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway.
T26424 A 60586 A60586,A-60586
A 60586, a non-azole inhibitor of ergosterol biosynthesis, inhibits lanosterol 14alpha-demethylase and displays in-vitro antifungal activity.
T40798 Triflumizole
Triflumizole, an imidazole fungicide, acts as an inhibitor of ergosterol biosynthesis. This widely utilized compound effectively controls powdery mildew and scabs on a range of fruits and crops.
T8812 Amorolfine HCL Antibiotic
Amorolfine HCL is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell ...
T68998 Parconazole Free Base
Parconazole Free Base is used in veterinary as an oral fungicide with a broad-spectrum activity against dermatophytes, yeasts, and others fungi. This compound does not have any antibacterial effect. The mechanism of acti...
T60853 (Z)-Lanoconazole
(Z)-Lanoconazole is the Z configuration of Lanoconazole which used for dermatophytosis and onychomycosis investigation. Lanoconazole inhibits sterol 14-alpha demethylase and blocks fungal membrane ergosterol biosynthesis...
T79551 Antifungal agent 69
Antifungal agent 69 (compound 13), a eugenol-imidazole derivative, demonstrates targeted activity against Candida albicans with a minimum inhibitory concentration (MIC) of 4.6 μM, while exhibiting negligible cytotoxicity...
T79467 Antifungal agent 60
Antifungal agent 60 (compound 16), a broad-spectrum ergosterol biosynthesis inhibitor, demonstrates potent activity against seven human pathogenic fungal species, including two fluconazole-resistant C. albicans isolates ...
T74273 Antifungal agent 52
Antifungal agent 52 (compound 6c), a tetrazole derivative, inhibits ergosterol synthesis and significantly exhibits antifungal activity against Candida albicans by affecting the permeabilization of the C. albicans sessil...
T83069 Antifungal agent 75
Antifungal agent 75 (compound 6r) effectively combats Candida albicans by substantially inhibiting biofilm formation, enhancing cell membrane permeability, diminishing membrane ergosterol levels, impairing membrane struc...
T64105 Voriconazole camphorsulfonate
Voriconazole (UK-109496) camphorsulfonate is a second generation broad-spectrum triazole antifungal compound that exhibits inhibition of fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exhibits antifungal e...
T79550 Antifungal agent 68
Antifungal agent 68 (compound 10) effectively combats fungal infections caused by Candida and Cryptococcus gattii through the inhibition of ergosterol biosynthesis, likely via interaction with lanosterol 14α-demethylase ...
T78899 Laccase-IN-1
Laccase-IN-1 (compound 4b) is an orally active laccase inhibitor, demonstrating an IC50 of 11.3 μM. It exhibits both protective and curative effects against B. dothidea infections in apple fruits. The compound increases ...

Compounds

Dehydroergosterol
T37858
Synonym: 9,11-dehydro Ergosterol,DHE
Target:
Butoconazole
T8490
Synonym: 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole
Target: Antifungal
Prochloraz
T20625
Synonym: Sporgon,Prelude
Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal
Isavuconazole
T2305
Synonym: BAL-4815,RO-0094815
Target: P450, Antibiotic, Antifungal
Epoxiconazole
T19721
Synonym: BAS-480F,BAS 480F,EC 406 850 2,BAS480F,EC-406-850-2
Target: Antifungal
9,11-Dehydroergosterol peroxide
T124072
Synonym:
Target:
Myclobutanil
T2199
Synonym: Systhane
Target: Antifungal
Amorolfine hydrochloride
T0187
Synonym: Amorolfin,Amorolfine HCl,Ro 14-4767/002
Target: Antibiotic, Antifungal
Sulconazole mononitrate
T6686
Synonym: Exelderm,Sulconazole Nitrate,RS 44872
Target: Antibacterial, Antibiotic, Antifungal
Bifonazole
T1187
Synonym: Bay H-4502
Target: P450, Antibiotic, Antifungal
Isavuconazonium sulfate
T3934
Synonym:
Target: Antifungal
Difenoconazole
T7866
Synonym:
Target: Others, Antifungal
Terconazole
T2213
Synonym: Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,R42470
Target: Antifection, Antifungal
Hexaconazole
T5966
Synonym: (-)-Hexaconazol
Target: Reactive Oxygen Species, Antifungal
Liranaftate
T1497
Synonym: Piritetrate,M-732
Target: Antifungal
Elubiol
T35353
Synonym: dichlorophenyl imidazoldioxolan
Target: Antibacterial
Butoconazole nitrate
T1438
Synonym: RS 35887
Target: Estrogen/progestogen Receptor, Antifungal
Naftifine hydrochloride
T1543
Synonym: Naftifungin,Naftifine HCl,Naftin,Exoderil
Target: Hedgehog/Smoothened, Antibiotic, Antifungal
Oxiconazole nitrate
T1290
Synonym: Ro 13-8996
Target: Others, Antibiotic, Antifection, Antifungal
Tak 187
T28914
Synonym: Tak-187,Tak187
Target:
Myclobutanil hydroxide
T71341
Synonym:
Target:
Lanoconazole
T15708
Synonym:
Target: Antifungal
Triadimenol
T34924
Synonym: Spinnaker,UK199,Baytan,UK 199,UK-199
Target:
Butenafine
T21365
Synonym: KP363,KP 363,Mentax,KP-363,Butop
Target:
Terbinafine lactate
T6702L
Synonym: DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT
Target:
A 60586
T26424
Synonym: A60586,A-60586
Target:
Triflumizole
T40798
Synonym:
Target:
Amorolfine HCL
T8812
Synonym:
Target: Antibiotic
Parconazole Free Base
T68998
Synonym:
Target:
(Z)-Lanoconazole
T60853
Synonym:
Target:
Antifungal agent 69
T79551
Synonym:
Target:
Antifungal agent 60
T79467
Synonym:
Target:
Antifungal agent 52
T74273
Synonym:
Target:
Antifungal agent 75
T83069
Synonym:
Target:
Voriconazole camphorsulfonate
T64105
Synonym:
Target:
Antifungal agent 68
T79550
Synonym:
Target:
Laccase-IN-1
T78899
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2912 Ergosterol Provitamin D,Ergosterin,Provitamin D2 Others , Endogenous Metabolite
Ergosterol (Provitamin D2) is a steroid extracted from Ganoderma lucidum cystocarp.
TN7071 Ergosterol Acetate Ergosta-5,7,22-trien-3-beta-yl acetate Others
Ergosterol Acetate (Ergosta-5,7,22-trien-3-beta-yl acetate) is one of the acetate derivatives of Ergosterol from Monascus anka.
TN5288 Ergosterol peroxide glucoside Ergosterol peroxide 3-O-β-D-glucopyranoside
Ergosterol peroxide exhibits anti-cancer, amoebicidal, anticomplementary, antibacterial, antiviral, anti-oxdiant, and anti-melanogenic activities. Ergosterol peroxide could as an anti-atherosclerosis agent, it exhibits h...
TN3984 Ergosterol glucoside Others
Ergosterol glucoside is a natural product from Rehmannia glutinosa.
TMA1743 Ergosterol peroxide ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...
T1011 Itraconazole R51211 P450 , Hedgehog/Smoothened , Antibiotic , Autophagy , Antifungal
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
TN7127 5,6-Epoxyergosterol Others
5,6-Epoxyergosterol is derived from the endophytic fungus Phyllosticta capitalensis.
T0344L Miconazole nitrate NSC 169434 Nitrate,R18134 nitrate Antibacterial , Antibiotic , Antifungal
Miconazole nitrate (R18134 nitrate), an imidazole antifungal agent, selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes.
T0146 Tioconazole UK-20349,Vagistat Antibiotic , Antifection , Antifungal
Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and pr...
T1086 Vitamin D2 Calciferol,Ergocalciferol,Ercalciol DNA/RNA Synthesis , Endogenous Metabolite
Ergocalciferol (Vitamin D2 (Calciferol)) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder tumor promotion by sodium saccharin, and it in...
T6702 Terbinafine Terbinex,SF 86-327,Lamisil,TDT 067 Antibacterial , Antibiotic , Antifungal
Terbinafine (TDT 067) is a synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important c...
T1067 Amphotericin B NSC 527017 Antibiotic , Antifungal
Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species. Amphotericin B irreversibly binds to ergosterol and disrupts the integrity of cell membranes, resulting ...
T38036 Lumisterol
Lumisterol (9β,10α-Ergosterol), a steroid compound and the (9β,10α)-stereoisomer of Ergosterol, serves as a photoprotective agent shielding against UVB-induced DNA damage and exhibits anti-proliferative activities[1].
T28379 PF-1163B PF1163B,(-)-PF1163B,PF 1163B
PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candid...
T80777 Withaphysalin R
Withaphysalin R (compound 5), a withanolide derived from the Solanaceae family, possesses an ergosterol-based steroid ester structure. This compound exhibits notable activities such as cytotoxic, immunosuppressive, antit...

Natural Products

Ergosterol
T2912
Synonym: Provitamin D,Ergosterin,Provitamin D2
Target: Others, Endogenous Metabolite
Ergosterol Acetate
TN7071
Synonym: Ergosta-5,7,22-trien-3-beta-yl acetate
Target: Others
Ergosterol peroxide glucoside
TN5288
Synonym: Ergosterol peroxide 3-O-β-D-glucopyranoside
Target:
Ergosterol glucoside
TN3984
Synonym:
Target: Others
Ergosterol peroxide
TMA1743
Synonym:
Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection
Itraconazole
T1011
Synonym: R51211
Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal
5,6-Epoxyergosterol
TN7127
Synonym:
Target: Others
Miconazole nitrate
T0344L
Synonym: NSC 169434 Nitrate,R18134 nitrate
Target: Antibacterial, Antibiotic, Antifungal
Tioconazole
T0146
Synonym: UK-20349,Vagistat
Target: Antibiotic, Antifection, Antifungal
Vitamin D2
T1086
Synonym: Calciferol,Ergocalciferol,Ercalciol
Target: DNA/RNA Synthesis, Endogenous Metabolite
Terbinafine
T6702
Synonym: Terbinex,SF 86-327,Lamisil,TDT 067
Target: Antibacterial, Antibiotic, Antifungal
Amphotericin B
T1067
Synonym: NSC 527017
Target: Antibiotic, Antifungal
Lumisterol
T38036
Synonym:
Target:
PF-1163B
T28379
Synonym: PF1163B,(-)-PF1163B,PF 1163B
Target:
Withaphysalin R
T80777
Synonym:
Target:

Recombinant Proteins

Species：
Mycobacterium tuberculosis (1)
SVG-Saccharomyces cerevisiae (1)
Saccharomyces cerevisiae (1)
Expression System：
E. coli (2)
Baculovirus (1)
Tag：
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
N-terminal GST-tagged (1)
Cat No. Product Name Species Expression System
TMPH-03447 ERG11 Protein, S. cerevisiae, Recombinant (GST) Saccharomyces cerevisiae E. coli
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
TMPH-03017 CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) Mycobacterium tuberculosis Baculovirus
Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethy...
TMPH-03460 ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) SVG-Saccharomyces cerevisiae E. coli
Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol....
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