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Cat No. | Product Name | Synonyms | Targets |
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T37858 | Dehydroergosterol | 9,11-dehydro Ergosterol,DHE | |
Dehydroergosterol is a naturally occurring, fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes.[1] It is readily bound by cholesterol-binding proteins and h... | |||
T8490 | Butoconazole | 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole | Antifungal |
Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent | |||
T20625 | Prochloraz | Sporgon,Prelude | Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal |
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and... | |||
T2305 | Isavuconazole | BAL-4815,RO-0094815 | P450 , Antibiotic , Antifungal |
Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabr... | |||
T19721 | Epoxiconazole | BAS-480F,BAS 480F,EC 406 850 2,BAS480F,EC-406-850-2 | Antifungal |
Epoxiconazole (BAS-480F) is a 14-α demethylase inhibitor. It inhibits ergosterol synthesis and fungal cell wall formation. | |||
T124072 | 9,11-Dehydroergosterol peroxide | ||
9,11-Dehydroergosterol peroxide is a useful organic compound for research related to life sciences. The catalog number is T124072 and the CAS number is 86363-50-0. | |||
T2199 | Myclobutanil | Systhane | Antifungal |
Myclobutanil (Systhane) is a triazole chemical used as a fungicide. It is a steroid demethylation inhibitor, specifically inhibiting ergosterol biosynthesis. Ergosterol is a critical component of fungal cell membranes. | |||
T0187 | Amorolfine hydrochloride | Amorolfin,Amorolfine HCl,Ro 14-4767/002 | Antibiotic , Antifungal |
Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function an... | |||
T6686 | Sulconazole mononitrate | Exelderm,Sulconazole Nitrate,RS 44872 | Antibacterial , Antibiotic , Antifungal |
Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demeth... | |||
T1187 | Bifonazole | Bay H-4502 | P450 , Antibiotic , Antifungal |
Bifonazole (Bay H-4502) acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a substance called ergosterol, which is an essent... | |||
T3934 | Isavuconazonium sulfate | Antifungal | |
Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh... | |||
T7866 | Difenoconazole | Others , Antifungal | |
Difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell ... | |||
T2213 | Terconazole | Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,R42470 | Antifection , Antifungal |
Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damag... | |||
T5966 | Hexaconazole | (-)-Hexaconazol | Reactive Oxygen Species , Antifungal |
Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of ... | |||
T1497 | Liranaftate | Piritetrate,M-732 | Antifungal |
Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity. Liranaftate inhibits fungal squalene epoxidase, an enzyme that plays a key role in the synthesis of sterol which is ... | |||
T35353 | Elubiol | dichlorophenyl imidazoldioxolan | Antibacterial |
Elubiol (dichlorophenyl imidazoldioxolan) is a new broad-spectrum antifungal product of imidazole, which can inhibit the biosynthesis of fungal ergosterol and change the composition of other lipid compounds in the cell m... | |||
T1438 | Butoconazole nitrate | RS 35887 | Estrogen/progestogen Receptor , Antifungal |
Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversi... | |||
T1543 | Naftifine hydrochloride | Naftifungin,Naftifine HCl,Naftin,Exoderil | Hedgehog/Smoothened , Antibiotic , Antifungal |
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its... | |||
T1290 | Oxiconazole nitrate | Ro 13-8996 | Others , Antibiotic , Antifection , Antifungal |
Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole... | |||
T28914 | Tak 187 | Tak-187,Tak187 | |
Tak 187 is a long-lasting inhibitor of ergosterol biosynthesis. | |||
T71341 | Myclobutanil hydroxide | ||
Myclobutanil hydroxide is a 14-α demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. It also weakly inhibits testosterone production. | |||
T15708 | Lanoconazole | Antifungal | |
Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alph... | |||
T34924 | Triadimenol | Spinnaker,UK199,Baytan,UK 199,UK-199 | |
Triadimenol is a systemic fungicide with a broad spectrum. It inhibits the ergosterol - and gibberellin - biosynthesis, and thus the rate of cell division. | |||
T21365 | Butenafine | KP363,KP 363,Mentax,KP-363,Butop | |
Butenafine hydrochloride is a hydrochloride of butenafine, which inhibits squalene epoxidase to inhibit the synthesis of ergosterol, leading to the increased permeability of the cell membranes, allowing their contents to... | |||
T6702L | Terbinafine lactate | DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT | |
Terbinafine, a synthetic allylamine antifungal, inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. | |||
T26424 | A 60586 | A60586,A-60586 | |
A 60586, a non-azole inhibitor of ergosterol biosynthesis, inhibits lanosterol 14alpha-demethylase and displays in-vitro antifungal activity. | |||
T40798 | Triflumizole | ||
Triflumizole, an imidazole fungicide, acts as an inhibitor of ergosterol biosynthesis. This widely utilized compound effectively controls powdery mildew and scabs on a range of fruits and crops. | |||
T8812 | Amorolfine HCL | Antibiotic | |
Amorolfine HCL is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell ... | |||
T68998 | Parconazole Free Base | ||
Parconazole Free Base is used in veterinary as an oral fungicide with a broad-spectrum activity against dermatophytes, yeasts, and others fungi. This compound does not have any antibacterial effect. The mechanism of acti... | |||
T60853 | (Z)-Lanoconazole | ||
(Z)-Lanoconazole is the Z configuration of Lanoconazole which used for dermatophytosis and onychomycosis investigation. Lanoconazole inhibits sterol 14-alpha demethylase and blocks fungal membrane ergosterol biosynthesis... | |||
T79551 | Antifungal agent 69 | ||
Antifungal agent 69 (compound 13), a eugenol-imidazole derivative, demonstrates targeted activity against Candida albicans with a minimum inhibitory concentration (MIC) of 4.6 μM, while exhibiting negligible cytotoxicity... | |||
T79467 | Antifungal agent 60 | ||
Antifungal agent 60 (compound 16), a broad-spectrum ergosterol biosynthesis inhibitor, demonstrates potent activity against seven human pathogenic fungal species, including two fluconazole-resistant C. albicans isolates ... | |||
T74273 | Antifungal agent 52 | ||
Antifungal agent 52 (compound 6c), a tetrazole derivative, inhibits ergosterol synthesis and significantly exhibits antifungal activity against Candida albicans by affecting the permeabilization of the C. albicans sessil... | |||
T83069 | Antifungal agent 75 | ||
Antifungal agent 75 (compound 6r) effectively combats Candida albicans by substantially inhibiting biofilm formation, enhancing cell membrane permeability, diminishing membrane ergosterol levels, impairing membrane struc... | |||
T64105 | Voriconazole camphorsulfonate | ||
Voriconazole (UK-109496) camphorsulfonate is a second generation broad-spectrum triazole antifungal compound that exhibits inhibition of fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exhibits antifungal e... | |||
T79550 | Antifungal agent 68 | ||
Antifungal agent 68 (compound 10) effectively combats fungal infections caused by Candida and Cryptococcus gattii through the inhibition of ergosterol biosynthesis, likely via interaction with lanosterol 14α-demethylase ... | |||
T78899 | Laccase-IN-1 | ||
Laccase-IN-1 (compound 4b) is an orally active laccase inhibitor, demonstrating an IC50 of 11.3 μM. It exhibits both protective and curative effects against B. dothidea infections in apple fruits. The compound increases ... |
Cat No. | Product Name | Synonyms | Targets |
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T2912 | Ergosterol | Provitamin D,Ergosterin,Provitamin D2 | Others , Endogenous Metabolite |
Ergosterol (Provitamin D2) is a steroid extracted from Ganoderma lucidum cystocarp. | |||
TN7071 | Ergosterol Acetate | Ergosta-5,7,22-trien-3-beta-yl acetate | Others |
Ergosterol Acetate (Ergosta-5,7,22-trien-3-beta-yl acetate) is one of the acetate derivatives of Ergosterol from Monascus anka. | |||
TN5288 | Ergosterol peroxide glucoside | Ergosterol peroxide 3-O-β-D-glucopyranoside | |
Ergosterol peroxide exhibits anti-cancer, amoebicidal, anticomplementary, antibacterial, antiviral, anti-oxdiant, and anti-melanogenic activities. Ergosterol peroxide could as an anti-atherosclerosis agent, it exhibits h... | |||
TN3984 | Ergosterol glucoside | Others | |
Ergosterol glucoside is a natural product from Rehmannia glutinosa. | |||
TMA1743 | Ergosterol peroxide | ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection | |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr... | |||
T1011 | Itraconazole | R51211 | P450 , Hedgehog/Smoothened , Antibiotic , Autophagy , Antifungal |
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis. | |||
TN7127 | 5,6-Epoxyergosterol | Others | |
5,6-Epoxyergosterol is derived from the endophytic fungus Phyllosticta capitalensis. | |||
T0344L | Miconazole nitrate | NSC 169434 Nitrate,R18134 nitrate | Antibacterial , Antibiotic , Antifungal |
Miconazole nitrate (R18134 nitrate), an imidazole antifungal agent, selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes. | |||
T0146 | Tioconazole | UK-20349,Vagistat | Antibiotic , Antifection , Antifungal |
Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and pr... | |||
T1086 | Vitamin D2 | Calciferol,Ergocalciferol,Ercalciol | DNA/RNA Synthesis , Endogenous Metabolite |
Ergocalciferol (Vitamin D2 (Calciferol)) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder tumor promotion by sodium saccharin, and it in... | |||
T6702 | Terbinafine | Terbinex,SF 86-327,Lamisil,TDT 067 | Antibacterial , Antibiotic , Antifungal |
Terbinafine (TDT 067) is a synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important c... | |||
T1067 | Amphotericin B | NSC 527017 | Antibiotic , Antifungal |
Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species. Amphotericin B irreversibly binds to ergosterol and disrupts the integrity of cell membranes, resulting ... | |||
T38036 | Lumisterol | ||
Lumisterol (9β,10α-Ergosterol), a steroid compound and the (9β,10α)-stereoisomer of Ergosterol, serves as a photoprotective agent shielding against UVB-induced DNA damage and exhibits anti-proliferative activities[1]. | |||
T28379 | PF-1163B | PF1163B,(-)-PF1163B,PF 1163B | |
PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candid... | |||
T80777 | Withaphysalin R | ||
Withaphysalin R (compound 5), a withanolide derived from the Solanaceae family, possesses an ergosterol-based steroid ester structure. This compound exhibits notable activities such as cytotoxic, immunosuppressive, antit... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03447 | ERG11 Protein, S. cerevisiae, Recombinant (GST) | Saccharomyces cerevisiae | E. coli |
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | |||
TMPH-03017 | CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) | Mycobacterium tuberculosis | Baculovirus |
Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethy... | |||
TMPH-03460 | ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) | SVG-Saccharomyces cerevisiae | E. coli |
Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol.... |