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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13829 | Oiligodendrocyte differentiation promoter 1 | Others | |
Oiligodendrocyte differentiation promoter 1 is a promoter of oiligodendrocyte differentiation . | |||
T7693 | Thiorphan | Neprilysin | |
Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM). | |||
T8839 | ICCB280 | Apoptosis , Others | |
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavo... | |||
T39508 | KY-02327 | Others | |
KY-02327, a metabolically stabilized analog of KY-02061, serves as a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. This compound activates the Wnt/β-catenin pathway, thereby promoting osteoblast differenti... | |||
T1748 | Kartogenin | KGN | TGF-beta/Smad |
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. | |||
T2340 | AC1NS4RE | Tyrosinase | |
It is a tyrosine kinase inhibitor. | |||
T2052 | KY02111 | Wnt/beta-catenin | |
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC. | |||
T9243 | PFI-90 | Histone Demethylase , Others | |
PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death. | |||
TP1328 | TB500 | Others | |
TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4. | |||
T9210 | CD73-IN-4 | CD73 | |
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor | |||
T1176 | Racecadotril | Acetorphan | Neprilysin , Proteasome |
Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis. | |||
T13336 | VTP50469 | Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase | |
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity. | |||
T1938 | FLT3-IN-2 | FLT | |
FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM). | |||
T10425 | AZ084 | CCR | |
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma. | |||
T4428 | CCT241736 | FLT , Aurora Kinase | |
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica... | |||
T3079 | GSK1838705A | IGF-1R , JNK , S6 Kinase , ALK | |
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases. | |||
T11298 | FLT3-IN-3 | FLT | |
FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively. | |||
TQ0106 | Sacubitrilat | LBQ-657 | Neprilysin |
Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP). | |||
T15612 | JH-VIII-157-02 | Microtubule Associated , ALK | |
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L... | |||
T9765 | TJ-M2010-5 | MyD88 | |
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies. | |||
T22814 | GSA-10 | Hedgehog/Smoothened | |
Smoothened (Smo) receptor agonist | |||
T6756 | AMG 925 | FLT , CDK | |
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. | |||
T2612 | CEP-28122 | ALK | |
CEP-28122 is a highly potent and selective orally active ALK inhibitor. | |||
T2272 | BPR1J-097 | BPR1J097 | FLT |
BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM). | |||
T15335 | FN-1501 | FLT , CDK | |
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity. | |||
T5521 | Bropirimine | U-54461 | TLR |
Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines. | |||
T16153 | MS4078 | ALK , Ligand for E3 Ligase | |
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK. | |||
T16159 | Muramyl dipeptide | MDP | NOD |
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation... | |||
T3635 | IQ 1 | IQ1,IQ-1 | Wnt/beta-catenin |
IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on. | |||
T3065 | TG101209 | Apoptosis , FLT , c-RET , JAK , Autophagy | |
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM. | |||
T6138 | TCS 359 | FLT3 Inhibitor | FLT |
TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM. | |||
T7673 | ATH686 | ATH 686 | Apoptosis , FLT |
ATH686 is an potent and selective Inhibitor of FLT3. | |||
T9473 | 4SC-203 | FLT | |
4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEG... | |||
T11254 | F-1 | ROS , ALK , ROS Kinase | |
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa... | |||
T6020 | Pacritinib | SB1518 | FLT , Tyrosine Kinases , JAK |
Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays). | |||
T1962 | ASP3026 | ASP 3026 | Apoptosis , ALK |
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS. | |||
T28036 | MI-2-2 | MI22,MI 2 2 | Histone Methyltransferase |
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM. | |||
T8317 | 5'-Fluoroindirubinoxime | 5'-FIO | FLT |
5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM). | |||
T12341 | P-gp inhibitor 1 | Others , P-gp | |
P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells). | |||
TQ0235 | AC710 | FLT , PDGFR , c-Kit | |
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ). | |||
T8426 | Encequidar | HM30181,HM30181A | P-gp |
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor. | |||
T16144 | MRX-2843 | UNC2371 | Others , FLT |
MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively). | |||
T2341 | KW-2449 | KW2449 | Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase |
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR. | |||
T6115 | Fostamatinib | R788 | FLT , Syk , Monoamine Transporter , Adenosine Receptor |
Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn. | |||
T16561 | Polyoxyethylene stearate | POES | Antibacterial , P-gp |
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying. | |||
T4015 | HG-14-10-04 | ALK | |
HG-14-10-04 is a potent and specific ALK inhibitor. | |||
T3621 | Brigatinib | AP-26113 | EGFR , FLT , ROS , IGF-1R , ALK |
Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor. | |||
T3455 | Merestinib | LY2801653 | Discoidin Domain Receptor (DDR) , FLT , c-Met/HGFR , ROS , ROS Kinase |
Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosph... | |||
T6287 | Tariquidar | XR9576 | P-gp |
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines. | |||
T11071 | Dofequidar fumarate | MS-209 | P-gp |
Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3816 | Velutin | NF-κB , HIF/HIF Prolyl-Hydroxylase | |
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ... | |||
TN5888 | Toddaculin | Others | |
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in... | |||
TN1040 | Skullcapflavone II | COX , Antibacterial , TGF-beta/Smad | |
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of al... | |||
T5751 | Tigogenin | Others | |
Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis. | |||
TN1124 | Neoeriocitrin | AChE | |
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor. | |||
T2S0712 | Sinigrin | Allylglucosinolate,2-Propenylglucosinolate | Others |
Sinigrin (2-Propenylglucosinolate), a glucosinolate, is used as a systrate to identify, differentiate and characterize myrosinase(s)/thioglucoside glucohydrolase(s)/thioglucosidase(s). Sinigrin is used as a reference mat... | |||
TN1651 | Furanodiene | Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp | |
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans. | |||
T8152 | 6-Demethoxytangeretin | MAPK , ALK | |
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. | |||
T3S0012 | Coniferyl ferulate | P-gp , GST | |
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ... | |||
T2S0223 | Isosinensetin | 6-Demethoxynobiletin | Antioxidant , HIV Protease , Antibacterial , P-gp |
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities. | |||
TN4761 | Phellamurin | P-gp | |
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini... | |||
TJS1159 | Chrysosplenetin | Chrysosptertin B | P450 , Ferroptosis , P-gp |
Chrysosplenetin is a metabolic inhibitor of artemisinin. | |||
T3002 | Piperine | 1-Piperoylpiperidine,Bioperine | P450 , Endogenous Metabolite , P-gp , Autophagy |
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders. | |||
T6S0033 | Crotonoside | Isoguanosine,2-HYDROXYADENOSINE | Others , FLT , HDAC |
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stim... | |||
T2S0271 | Voacamine | Voacanginine | Cannabinoid Receptor , P-gp |
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini... | |||
T2S1200 | Sinapine | Antioxidant , P-gp , AChE | |
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities. | |||
T19676 | Tributyrin | NSC661583,NSC 661583,NSC-661583 | Apoptosis |
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracell... | |||
T4034 | Solamargine | Solamargin,δ-Solanigrine | Apoptosis , p38 MAPK , P-gp , STAT |
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel... | |||
T3392 | Sinapine thiocyanate | P-gp , AChE | |
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o... | |||
TJS0328 | Nordalbergin | 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One | Others |
Nordalbergin, a coumarin isolated from the bark of Dalbergia sissoo, can significantly induce the differentiation of HL-60 cells. | |||
T13502 | 3-Oxo-5β-cholanoic acid | Dehydrolithocholic acid | ROR |
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM)... | |||
T2799 | (20S)-Protopanaxadiol | 20-Epiprotopanaxadiol,20(S)-APPD | Apoptosis , Reactive Oxygen Species , P-gp |
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin. | |||
TN1757 | Hypophyllanthin | Potassium Channel , Calcium Channel , P-gp | |
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. | |||
TN1525 | Convallatoxin | NF-κB , P-gp , PPAR | |
Convallatoxin is a natural product | |||
T1048 | Estradiol | E2,17β-Estradiol,17β-Oestradiol,β-Estradiol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be... | |||
TN7036 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14 | Wnt/beta-catenin |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa... | |||
TCS2336 | Evodine | P-gp | |
1. Evodine has antinociceptive activity. | |||
T4085 | Paris saponin VII | Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII | Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy |
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation. | |||
T6627 | Phosphoramidon Disodium | Phosphoramidon Disodium Salt | RAAS , Neprilysin , Others |
Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. | |||
T2185 | L-Ascorbic acid 2-phosphate trisodium | L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate | Reactive Oxygen Species , c-Met/HGFR , Endogenous Metabolite |
L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) is used in biocatalytic dephosphorylation for electric power generation and electrochemical detection assays. | |||
T22644 | C2 Ceramide | Ceramide | Others |
A potent modulator of cell proliferation and differentiation. | |||
T3488 | Tectorigenin | 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine | Apoptosis |
Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Re... | |||
T8015 | 4-METHOXYCHALCONE | 2-(4-Methoxybenzal)Acetophenone | Others |
4-METHOXYCHALCONE (2-(4-Methoxybenzal)Acetophenone) is a natural compound that enhanced adipocyte differentiation, | |||
T0421 | I-Inositol | Inositol,myo-Inositol,meso-Inositol | Endogenous Metabolite |
i-Inositol (myo-Inositol) is a intracellular phosphate compound, involved in cell signaling and may stimulate tumor cell differentiation. | |||
T13768 | (+)-Medicarpin | Estrogen/progestogen Receptor | |
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium flo... | |||
T3808 | Icariside I | Lcariside I,Icariin I,Icarisid I | Others |
Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts. | |||
T1882 | Meisoindigo | N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III | Apoptosis |
Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML). | |||
T2848 | Osthole | Osthol,NSC 31868,Ostol | Apoptosis , HBV , Parasite , Histamine Receptor |
Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation. | |||
TN3209 | 3′,4′,7-Trihydroxyflavone | ATPase , Others , p38 MAPK , NF-κB | |
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclasto... | |||
T3924 | Astragaloside II | Astrasieversianin VIII | TGF-beta/Smad |
Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, ... | |||
TQ0198 | Phorbol 12-myristate 13-acetate | PMA | NF-κB , S1P Receptor , PKC |
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation. | |||
T3925 | Astragaloside I | Cyclosieversioside B,Astrasieversianin IV | Wnt/beta-catenin |
Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt/β-catenin signaling pathway and can be used to study osteogen... | |||
T6062 | Brefeldin A | BFA,Ascotoxin,Cyanein,Decumbin | ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9 |
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ... | |||
T3220 | Euphorbiasteroid | Euphobiasteroid,Euphorbia factor L1 | Others , AMPK |
Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation. | |||
TN2121 | 3,5,7,3′,4′-Pentamethoxyflavone | Quercetin 3,5,7,3,4-pentamethyl ether | Others |
3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product. It can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation. | |||
T1086 | Vitamin D2 | Calciferol,Ergocalciferol,Ercalciol | DNA/RNA Synthesis , Endogenous Metabolite |
Ergocalciferol (Vitamin D2 (Calciferol)) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder tumor promotion by sodium saccharin, and it in... | |||
T3810 | Saikosaponin B2 | Others , HCV Protease | |
Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with... | |||
T5770 | Alisol B | RANKL/RANK | |
Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-... | |||
T0650 | Phenyl acetate | Acetylphenol,Phenol acetate,Acetic acid phenyl ester | Others , Endogenous Metabolite |
Phenyl acetate (Acetic acid phenyl ester) is an aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibi... | |||
T3900 | Emodin-8-glucoside | Emodin glucoside B,Anthraglycoside B | Others |
Emodin-8-glucoside (Anthraglycoside B) functions to protect from focal cerebral injury induced by ischemia and reperfusion. Emodin-8-beta-D-glucoside directly stimulates cell proliferation and differentiation of osteobla... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02698 | CD14 Protein, Human, Recombinant (His) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-04727 | GDF-15 Protein, Human, Recombinant (His) | Human | Yeast |
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not... | |||
TMPY-01073 | GDF-15 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not... | |||
TMPY-01817 | GDF-10 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
BMP-3b / GDF-10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a ma... | |||
TMPY-03185 | METRN Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
METRN (Meteorin, Glial Cell Differentiation Regulator) is a Protein Coding gene. The encoded protein belongs to the meteorin family. It is broadly expressed in the brain, kidney, and other tissues. Meteorin is a novel se... | |||
TMPY-00697 | CD14 Protein, Human, Recombinant (hFc) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPJ-00662 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i... | |||
TMPJ-00898 | CD72 Protein, Human, Recombinant (Trx & His) | Human | E. coli |
B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, mon... | |||
TMPJ-00020 | IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cel... | |||
TMPJ-00607 | RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thy... | |||
TMPJ-00663 | GDF-8 Protein, Human/Mouse/Rat, Recombinant | Human,Mouse,Rat | Human Cells |
Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site whi... | |||
TMPJ-00713 | GDF-11 Protein, Human, Recombinant | Human | Human Cells |
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. ... | |||
TMPJ-00693 | EDF1 Protein, Human, Recombinant (His) | Human | E. coli |
Endothelial Differentiation-Related Factor 1 (EDF1) is a 148 amino acid transcriptional coactivator that contains 1 HTH cro/C1-type DNA-binding domain. It has been postulated that the protein functions as a bridging mole... | |||
TMPJ-01131 | UBE2V2 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N.... | |||
TMPY-04021 | NPDC1 Protein, Human, Recombinant (His) | Human | HEK293 |
TMPH-01013 | BMP-15 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. | |||
TMPJ-01414 | GDF-15 Protein, Mouse, Recombinant (His & Flag) | Mouse | Human Cells |
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a b... | |||
TMPJ-00339 | ALCAM Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ... | |||
TMPJ-00329 | CD19 Protein, Rhesus macaque, Recombinant (hFc) | Rhesus macaque | Human Cells |
CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recog... | |||
TMPJ-00292 | CD36 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ... | |||
TMPJ-00455 | SLAMF5 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based ... | |||
TMPJ-00775 | CD74 Protein, Mouse, Recombinant (mFc & His) | Mouse | Human Cells |
Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical rol... | |||
TMPJ-00228 | SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 a... | |||
TMPJ-00229 | SLAMF5 Protein, Human, Recombinant (His) | Human | Human Cells |
SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 a... | |||
TMPJ-00674 | RANK/TNFRSF11A Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acid... | |||
TMPJ-00966 | GDF-5 Protein, Human, Recombinant | Human | E. coli |
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor... | |||
TMPJ-00700 | GADD45B Protein, Human, Recombinant (His) | Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of g... | |||
TMPJ-00090 | FGF-9 Protein, Human, Recombinant | Human | E. coli |
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inc... | |||
TMPY-02575 | PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even... | |||
TMPY-00403 | FGF-7/KGF Protein, Human, Recombinant (His) | Human | E. coli |
Fibroblast growth factor 7 (FGF7) is a member of the fibroblast growth factor (FGF) family of proteins. FGF7 plays an important role in regulating the proliferation, migration, and differentiation of cells. FGF7 is of st... | |||
TMPY-02813 | ErbB4 Protein, Human, Rhesus, Recombinant (His) | Human,Rhesus | HEK293 |
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ... | |||
TMPJ-01466 | Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His) | Human | Human Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits ... | |||
TMPY-02483 | ATP citrate lyase/ACLY Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP... | |||
TMPY-00203 | LOXL2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 ... | |||
TMPY-06076 | LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
LILRA2 (Leukocyte Immunoglobulin Like Receptor A2, also known as LIR7 and ILT1) is a Protein Coding gene. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentatio... | |||
TMPY-04951 | CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated | Human | Baculovirus-Insect Cells |
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a typ... | |||
TMPY-03401 | CD27/TNFRSF7 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a typ... | |||
TMPY-04069 | Neurotrophin 3 Protein, Human, Recombinant | Human | E. coli |
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely relate... | |||
TMPJ-00327 | M-CSF/CSF1 Protein, Human, Recombinant (His) | Human | Human Cells |
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and th... | |||
TMPY-00804 | FGF-9 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Fibroblast growth factor 9 (FGF9) also known as Glia-activating factor or Heparin-binding growth factor 9, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell sur... | |||
TMPJ-01011 | FGF-9 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine a... | |||
TMPY-00539 | GSTA1 Protein, Human, Recombinant (His) | Human | HEK293 |
GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds. Glutathione S-transferases (GSTs) ... | |||
TMPY-02626 | FGF-18 Protein, Human, Recombinant (His) | Human | HEK293 |
Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes... | |||
TMPY-01630 | Syndecan-1 Protein, Human, Recombinant (His) | Human | HEK293 |
Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development... | |||
TMPY-02566 | Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 an... | |||
TMPY-00297 | IL-3 Protein, Human, Recombinant(aa 20-152) | Human | E. coli |
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cell... | |||
TMPY-00095 | IL-3 Protein, Human, Recombinant (His) | Human | HEK293 |
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cell... | |||
TMPY-04845 | IL-3 Protein, Mouse, Recombinant | Mouse | HEK293 |
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cell... | |||
TMPY-03532 | LIF Protein, Human, Recombinant (His) | Human | HEK293 |
Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone met... | |||
TMPY-02646 | NSE/ENO2 Protein, Human, Recombinant (His) | Human | E. coli |
The combination of silencing ENO2 and 2-deoxyglucose (2-DG) synergistically inhibited leukemia cell survival. ENO2 may be a biological marker for monitoring chemotherapeutic efficacy and relapse in ALL. Reduced ENO2 expr... | |||
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L2140 | Cancer Cell Differentiation Compound Library | 413 compounds | |
A unique collection of 413 cancer cell differentiation inducing compounds for high throughput and high content screening; | |||
L8000 | Stem Cell Differentiation Compound Library | 1213 compounds | |
A unique collection of 1213 stem cell differentiation signaling targeted compounds for high throughput and high content screening; | |||
L2630 | Neuronal Differentiation Compound Library | 680 compounds | |
680 compounds related to neuronal differentiation, suitable for the drug development of nervous system disease. | |||
L4200 | FDA-Approved Drug Library | 1729 compounds | |
A unique collection of 1729 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS); | |||
L4000 | Bioactive Compound Library | 14590 compounds | |
A collection of 14590 small molecule compounds with validated activity for high throughput screening (HTS), high content screening (HCS), cell induction, and target identification; | |||
L4010 | Bioactive Compounds Library Max | 22706 compounds | |
A collection of 22706 bioactive compounds for high-throughput screening, high-content screening, cell induction and target identification. | |||
L7900 | Osteogenesis Compound Library | 320 compounds | |
A unique collection of 320 osteogenesis related compounds for high throughput and high content screening; | |||
L3400 | Clinical Compound Library | 3480 compounds | |
A unique collection of 3480 compounds in clinical trial phases for high throughput screening (HTS) and high content screening (HCS); | |||
L4300 | Wnt/Hedgehog/Notch Compound Library | 240 compounds | |
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; | |||
L6100 | Polyphenolic Natural Product Library | 640 compounds | |
A unique collection of 640 natural polyphenolic compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L1400 | MAPK Inhibitor Library | 367 compounds | |
A unique collection of 367 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; | |||
L1610 | FDA-Approved Kinase Inhibitor Library | 266 compounds | |
A unique collection of 266 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening. | |||
L6150 | Covalent Natural Product Library | 596 compounds | |
Detialed biological information and pharmacological information of the products, providing theoretical direction and research basis for screening. | |||
L6000 | Natural Product Library for HTS | 4320 compounds | |
A unique collection of 4320 pure natural products and their derivatives with known biological activity for drug discovery, pharmacological study, stem cell differentiation, fingerprint study and quality research, and can... | |||
L6900 | Rare Natural Product Library | 180 compounds | |
A unique collection of 180 rare natural products, which can be used for high throughput screening (HTS) and high content screening (HCS); | |||
L4100 | TGF-beta/Smad Compound Library | 185 compounds | |
A unique collection of 185 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening; | |||
L3510 | Methylation Compound Library | 131 compounds | |
131 methylation-related compounds that can be used for high-throughput and high-content screening. | |||
L2600 | Neuronal Signaling Compound Library | 2540 compounds | |
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L6740 | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | 386 compounds | |
A collection of 386 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies. | |||
L8500 | HIF-1 Signaling Pathway Compound Library | 1352 compounds | |
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; |