d2-like

ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity.

Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schizophrenia.

SEP-363856 is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia.

SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment.

Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.

Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.

SB269652 is the pioneering drug-like allosteric modulator of the dopamine D2 receptor.

ECPLA is an LSD analog and a potent 5-HT2A agonist (EC50 of 14.6 nM), capable of stimulating Gq-mediated calcium flux. It exhibits high affinity for most serotonin receptors, α2-adrenergic receptors, and D2-like dopamine receptors.

N-Methylspiroperidol is a D2 receptor antagonist. This compound can be labeled as [18F]N-Methylspiroperidol, which allows for the investigation of its interaction with 5-HT2C receptors via PET (positron emission tomography), as well as examining the competition and impact of neurotransmitters like dopamine on these receptors.

Barium chloride dihydrate (Dichlorobarium dihydrate) is a potassium ion channel blocker. It inhibits the hyperpolarization of spinal central pattern generator (CPG) neurons mediated by D2-like receptors.

DCLK1-IN-4 (compound D2) is a potent and selective inhibitor of doublecortin-like kinase 1 (DCLK1), with an IC50 of 70 nM. It is applicable to cancer research.

2-CMDO is a Dopamine D2-like receptor antagonist.

Nemonapride is a dopamine D2-like receptor antagonist.

5-HT2A serotonin and selective D2-like dopamine receptor antagonist

Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.

Eticlopride, an antipsychotic, is a Selective dopamine D2/D3 receptor antagonist (Ki: 0.5/0.16 nM).

Tipepidine is a non-narcotic antitussive with an antidepressant-like effect. Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK) ) (IC 50 = 7.0 μM) and subsequently activates VTA dopamine neurons.

NAZ2329 is the first cell-permeable inhibitor of the R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), which is a variant and preferentially inhibits PTPRZ (IC50=7.5 μM for hPTPRZ1) and PTPRG (IC50=4.8 μM for hPTPRG) compared to other PTPs. NAZ2329 inhibited the tumor growth of glioblastoma cells and exhibited stem cell-like properties compared to the whole (D1 + D2) fragment of PTPRZ.

Dioleoylphosphatidylglycerol (DOPG), a naturally occurring phospholipid, is synthesized through the action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). It functions to suppress the production of inflammatory mediators by macrophages triggered by the activation of toll-like receptor 2 (TLR2) by heat shock protein B4 (HSPB4) [1].

MeSeI exhibits weak inhibitory activity against monoamine oxidases MAO-A and MAO-B, with IC50 values of 198.8 µM. It modulates dopamine receptor D2 (dopamine receptorD2) and norepinephrine receptors α2, β1 (norepinephrine receptor α2, β1), displaying antidepressant-like effects in mice. Additionally, MeSeI is orally active.

Ezomycin D2 is an antifungal antibiotic effective primarily against plant pathogens such as Sclerotinia sclerotiorum and Botrytis cinerea. It helps control diseases like sclerotinia blight and gray mold in crops, as well as candidiasis.

TAT-D1 peptide is a selective D1-D2 heteromer antagonist. It disrupts D1-D2 receptor heterodimers by interacting with specific domains of the D2 receptor through its unique amino acid sequence, especially the two glutamic acid residues at the C-terminus of the D1 receptor. TAT-D1 peptide is used for studying the role of D1-D2 receptor heterodimers in regulating depression and anxiety-like behaviors.