d-77

AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.

D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro, with an IC50 of 0.95 μM, and exhibits antiviral activity with an EC50 of 0.49 μM. Additionally, it suppresses SARS-CoV-2 Mpro-induced antagonism of the host NF-κB innate immune response [1].

D77 is anti-HIV-1 inhibitor. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).

21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive radioimmunoassay for plasma 21-deoxycortisol to the detection of steroid-21-hydroxylase deficiencyAnn. Clin. Biochem.31(Pt. 1)56-64(1994) 2.Cristoni, S., Cuccato, D., Sciannamblo, M., et al.Analysis of 21-deoxycortisol, a marker of congenital adrenal hyperplasia, in blood by atmospheric pressure chemical ionization and electrospray ionization using multiple reaction monitoringRapid Commun. Mass Spectrom.18(1)77-82(2004)

Decyl β-D-glucopyranoside is an essential organic compound for life sciences research (catalog number: T66430, CAS number: 58846-77-8).

Decyl-β-D-Selenomaltoside is a useful organic compound for research related to life sciences. The catalog number is TF0111 and the CAS number is 1423269-77-5.

1''-O-beta-D-glucopyranosylformoside is a natural product for research related to life sciences. The catalog number is TMA1194 and the CAS number is 148245-77-6.

Dextrorphan-d3 Tartrate is a deuterated compound of Dextrorphan Tartrate. Dextrorphan Tartrate has a CAS number of 77-07-6. Dextrorphan D-tartrate is a noncompetitive NMDA glutamate receptor antagonist.