compound-52

NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.

BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK PTK6), displaying an IC50 of 30 nM, and effectively suppresses p-SAM68 with an IC50 of 52 nM. This compound serves as a valuable tool for evaluating BRK inhibitors' efficacy in xenograft breast tumor models, enabling in vivo activity assessment.

Dibutyl carbonate is a useful organic compound for research related to life sciences. The catalog number is T2152 and the CAS number is 542-52-9.

Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region (EC50= 27 nM). It does not bind to serotonin (5-HT), dopamine, muscarinic, nicotinic, adrenergic, glutamate, histamine, opioid, or GABA receptors at 1 μM. Unifiram (0.1 mg kg) improves memory in non-memory-impaired rats in a social learning test.2It also prevents memory deficits induced by the anticholinergic agent scopolamine, nicotinic receptor antagonist mecamylamine, GABABreceptor agonist baclofen, or α2-adrenergic receptor agonist clonidine in the passive avoidance test in mice when administered at a dose of 0.01 mg kg and prevents memory deficits induced by the AMPA kainate glutamate receptor antagonist NBQX at 0.1 mg kg.1 1.Romanelli, M.N., Galeotti, N., Ghelardini, C., et al.Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancersCNS Drug Rev.12(1)39-52(2006) 2.Ghelardini, C., Galeotti, N., Gualtieri, F., et al.The novel nootropic compound DM232 (unifiram) ameliorates memory impairment in mice and ratsDrug Develop. Res.56(1)23-32(2002)

2-(9-Decenyl)glutaconic acid is a useful organic compound for research related to life sciences. The catalog number is T123835 and the CAS number is 97207-52-8.

3,5-Di-O-galloylshikimic acid is a useful organic compound for research related to life sciences. The catalog number is T123852 and the CAS number is 95753-52-9.

Aromadendrin 4'-glucoside is a useful organic compound for research related to life sciences. The catalog number is T124038 and the CAS number is 87314-52-1.

Silenorubicoside A is a useful organic compound for research related to life sciences. The catalog number is T124083 and the CAS number is 857411-52-0.

Madurastatin B2 is a useful organic compound for research related to life sciences. The catalog number is T124249 and the CAS number is 768384-52-7.

Pencolide is a useful organic compound for research related to life sciences. The catalog number is T124546 and the CAS number is 61464-52-6.

7,8-Dihydroyangonin is a useful organic compound for research related to life sciences. The catalog number is T125064 and the CAS number is 3155-52-0.

Gleditsioside J is a useful organic compound for research related to life sciences. The catalog number is T125199 and the CAS number is 253123-52-3.

Melilotussaponin O1 is a useful organic compound for research related to life sciences. The catalog number is T125393 and the CAS number is 205441-52-7.

Centaureidin is a useful organic compound for research related to life sciences. The catalog number is T125588 and the CAS number is 17313-52-9.

Clopidogrel Related Compound B is a useful organic compound for research related to life sciences. The catalog number is T125846 and the CAS number is 144750-52-7.

4'-O-Glucopyranosylsinapic acid is a useful organic compound for research related to life sciences. The catalog number is T126287 and the CAS number is 117405-52-4.

PD-1 PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1 PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL 6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.

Gpr35modulator 2 (compound 52) serves as a modulator for GPR35. It is utilized in researching a variety of diseases related to GPR35.

Adekalant (also known as H 345 52) is an innovative antiarrhythmic compound characterized by minimal proarrhythmic activity. It blocks HERG-mediated currents in a concentration-dependent manner, with a half-maximal inhibitory concentration (IC50) of 230 nM. Adekalant binds preferentially to open channels and exhibits rapid kinetic behavior, being trapped when channels close. Its voltage-independent properties have been observed during square pulse and action potential clamp protocols. Research suggests that delaying the repolarization of human cardiac muscle through I(Kr) blockage is the primary mechanism of Adekalant’s action. It effectively blocks I(Kr) while having relatively low efficacy in blocking I(Ca), delaying ventricular repolarization without significantly increasing temporal or spatial dispersion and without inducing early afterdepolarizations or torsades de pointes (TdP).

Cryptophycin 52 is part of the antitumor compound family known as Cryptophycins. Its mechanism involves binding to tubulin, which leads to the inhibition of solid tumor growth and induces apoptosis. (NCI)

SARS-CoV-2-IN-52 (Compound 5) is an inhibitor of SARS-CoV-2 with a pIC50 of 0.3187.

α-Glucosidase-IN-82 (compound 8l) is a potent inhibitor of α-glucosidase, with an IC50 value of 13.66 μM. Its inhibitory activity is 52 times greater than that of Acarbose.

Casein kinase1δ-IN-28 (Compound 4) is an inhibitor of CK1ε, with an IC50 of 0.0146 μM. The human liver microsome metabolism rate for Casein kinase1δ-IN-28 is 52%.

COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.