compound-52

NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.

Indane-5-sulfonyl chloride ,with CAS No. 52205-85-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Indane-5-sulfonyl chloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-(Chloroacetamidoethyl)indole ,with CAS No. 52191-26-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-(Chloroacetamidoethyl)indole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Chloro-3H-imidazo[4,5-b]pyridine ,with CAS No. 52090-89-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Chloro-3H-imidazo[4,5-b]pyridine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound 5259117 is a standardized reagent specifically designed for biochemical experiments. It features stable chemical properties and clear reactivity, Compound 5259117 is suitable for a variety of routine biochemical testing scenarios.

BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM, and effectively suppresses p-SAM68 with an IC50 of 52 nM. This compound serves as a valuable tool for evaluating BRK inhibitors' efficacy in xenograft breast tumor models, enabling in vivo activity assessment.

Dibutyl carbonate is a useful organic compound for research related to life sciences. The catalog number is T2152 and the CAS number is 542-52-9.

Beauveriolide III, a cyclodepsipeptide found in Beauveria fungi, inhibits lipid droplet formation (at 3-10 μM) and cholesterol synthesis (IC50=0.41 μM). This compound also suppresses acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity (IC50=5.5 μM) and reduces atherosclerotic lesion size in Ldlr-/- and ApoE-/- mouse models (25-50 mg/kg).

Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region (EC50= 27 nM). It does not bind to serotonin (5-HT), dopamine, muscarinic, nicotinic, adrenergic, glutamate, histamine, opioid, or GABA receptors at 1 μM. Unifiram (0.1 mg/kg) improves memory in non-memory-impaired rats in a social learning test.2It also prevents memory deficits induced by the anticholinergic agent scopolamine, nicotinic receptor antagonist mecamylamine, GABABreceptor agonist baclofen, or α2-adrenergic receptor agonist clonidine in the passive avoidance test in mice when administered at a dose of 0.01 mg/kg and prevents memory deficits induced by the AMPA/kainate glutamate receptor antagonist NBQX at 0.1 mg/kg.1 1.Romanelli, M.N., Galeotti, N., Ghelardini, C., et al.Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancersCNS Drug Rev.12(1)39-52(2006) 2.Ghelardini, C., Galeotti, N., Gualtieri, F., et al.The novel nootropic compound DM232 (unifiram) ameliorates memory impairment in mice and ratsDrug Develop. Res.56(1)23-32(2002)

4-(Benzyloxycarbonylamino-methyl)-benzoic acid ,with CAS No. 58933-52-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(Benzyloxycarbonylamino-methyl)-benzoic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-(9-Decenyl)glutaconic acid is a useful organic compound for research related to life sciences. The catalog number is T123835 and the CAS number is 97207-52-8.

3,5-Di-O-galloylshikimic acid is a useful organic compound for research related to life sciences. The catalog number is T123852 and the CAS number is 95753-52-9.

Aromadendrin 4'-glucoside is a useful organic compound for research related to life sciences. The catalog number is T124038 and the CAS number is 87314-52-1.

Silenorubicoside A is a useful organic compound for research related to life sciences. The catalog number is T124083 and the CAS number is 857411-52-0.

Madurastatin B2 is a useful organic compound for research related to life sciences. The catalog number is T124249 and the CAS number is 768384-52-7.

Pencolide is a useful organic compound for research related to life sciences. The catalog number is T124546 and the CAS number is 61464-52-6.

7,8-Dihydroyangonin is a useful organic compound for research related to life sciences. The catalog number is T125064 and the CAS number is 3155-52-0.

Gleditsioside J is a useful organic compound for research related to life sciences. The catalog number is T125199 and the CAS number is 253123-52-3.

Melilotussaponin O1 is a useful organic compound for research related to life sciences. The catalog number is T125393 and the CAS number is 205441-52-7.

Centaureidin is a useful organic compound for research related to life sciences. The catalog number is T125588 and the CAS number is 17313-52-9.

Clopidogrel-related Compound B hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T125846 and the CAS number is 144750-52-7.

4'-O-Glucopyranosylsinapic acid is a useful organic compound for research related to life sciences. The catalog number is T126287 and the CAS number is 117405-52-4.

PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.

Gpr35modulator 2 (compound 52) serves as a modulator for GPR35. It is utilized in researching a variety of diseases related to GPR35.