cholesterol transport

Nicanartine is a cholesterol inhibitor that is used to treat cardiovascular disease and can be used to study atherosclerosis.

cholesterol-absorption inhibitor Intermediate 2 is a potent and orally active cholesterol absorption inhibitor that reduces blood cholesterol levels.

U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.

GW6340 is a selective LXR agonist with potential anticancer activity that promotes macrophage reverse cholesterol transport (mRCT) and can be used to study atherosclerosis.

Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.

Diethylumbelliferyl phosphate (DEUP) is a potent and selective inhibitor of cholesterol esterase that does not inhibit protein kinase A activity in vitro. It disrupts steroidogenesis by blocking cholesterol transport to mitochondria in steroidogenic cells, with an IC50 of 11.6 μM. This compound may also limit the absorption of dietary cholesterol.

AMPK activator17 (Compound 10g) is an orally bioavailable AMPK activator. It significantly inhibits lipogenesis (IC50: 3.4 μM) and improves dyslipidemia. By activating the AMPK pathway, AMPK activator17 suppresses early adipocyte differentiation (mitotic clonal expansion) and enhances mitochondrial function and fatty acid oxidation in mature adipocytes. It improves dyslipidemia through promoting cholesterol reverse transport. AMPK activator17 is applicable in research on obesity and associated metabolic disorders, such as type 2 diabetes and cardiovascular diseases.

Ginsenoside C-K hexapropionate ester (Structure 2) acts as a selective agonist for LXRα without significantly activating LXRβ. By stimulating LXRα, it enhances the expression of downstream genes such as ABCA1, facilitating reverse cholesterol transport and reducing lipid accumulation in macrophage-derived foam cells, making it useful for atherosclerosis research. This compound is a synthetic derivative, created by modifying the active metabolite of Panax notoginseng saponins, Ginsenoside Compound K, with propionic anhydride.

STARD3-IN-1 (Compound VS1) is a STARD3 inhibitor with an IC₅₀ of 35 μM. Overexpressed in various cancers, STARD3 is involved in cholesterol transport. STARD3-IN-1 exhibits antiproliferative activity in breast and colon cancer cells, significantly impairing their clonogenicity. It increases the levels of FAK and pTyr397-FAK proteins. STARD3-IN-1 is useful in breast and colon cancer research.

(E)-Guggulsterone is an isomer of guggulsterone. As an FXR antagonist, it reduces blood lipids, induces heme oxygenase-1 expression, blocks DENV NS2B/3B activity, and inhibits DENV replication.

Dehydroergosterol (DHE) is a naturally occurring fluorescent sterol analog that is a compound for real-time detection/elaboration of the sterol environment and intracellular sterol transport in organisms. Dehydroergosterol is a cholesterol mimetic that binds to cholesterol-binding proteins and can be used for real-time imaging of living cells. Dehydroergosterol is a cholesterol mimetic that binds to cholesterol-binding proteins and can be used for real-time imaging of living cells.

Sch 58053 is an analog of Ezetimibe and a selective inhibitor of lymphatic cholesterol transport in the intestine.

TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.TSPO ligand-1 is an AUTAC4-binding protein in the transmembrane domain of the outer mitochondrial membrane, which induces mitochondrial autophagy and promotes intracellular mitochondrial regeneration.TSPO ligand-1 is involved in intracellular cholesterol transport, and can be used as a biomarker for brain injury and neurodegeneration. TSPO ligand-1 is involved in intracellular cholesterol transport and can be used as a biomarker for brain damage and neurodegeneration.

1-Palmitoyl-D9-2-Palmitoyl-sn-glycero-3-PE is essential in the inner plasma membrane leaflet. This compound forms a condensed lipid monolayer with cholesterol through tight hydrogen bonding between 1,2-DPPE headgroups, enhancing membrane fluidity to support transport and signaling.

Cholesterol-13C5 is a form of cholesterol labeled with carbon-13 isotopes. Cholesterol (T0760) is the predominant sterol in mammals, constituting 20-25% of the plasma membrane structure. While the plasma membrane is highly permeable to water, it is relatively impermeable to ions and protons. Cholesterol (T0760) is crucial in determining membrane fluidity and permeability features, as well as the function of transport and signaling proteins. Additionally, cholesterol acts as an endogenous agonist of estrogen-related receptor α (ERRα).

Cholesterol-13C2 is a 13C-labeled form of cholesterol. This primary sterol in mammals constitutes 20-25% of the plasma membrane's structural components. While the plasma membrane is highly permeable to water, it remains relatively impermeable to ions and protons. Cholesterol (T0760) significantly influences membrane fluidity and permeability and is crucial for the function of transport and signaling proteins. Additionally, cholesterol acts as an endogenous agonist for estrogen-related receptor α (ERRα).

Cholesterol-13C3 is a 13C-labeled version of cholesterol. Cholesterol (T0760) is a primary sterol in mammals and constitutes 20-25% of the plasma membrane structure. The plasma membrane exhibits high permeability to water but is relatively impermeable to ions and protons. Cholesterol (T0760) plays a crucial role in determining membrane fluidity and permeability characteristics, as well as affecting the function of transport and signaling proteins. Additionally, cholesterol acts as an endogenous agonist of estrogen-related receptor alpha (ERRα).

Cholesterol-D1 is the deuterated form of Cholesterol. Cholesterol (T0760) is the principal sterol found in mammals, comprising 20-25% of the plasma membrane's structural components. While the membrane allows high permeability to water, it remains relatively impermeable to ions and protons. Cholesterol (T0760) is crucial for defining membrane fluidity and permeability characteristics, as well as for the function of transport and signaling proteins. Additionally, Cholesterol (T0760) acts as an endogenous agonist of the estrogen-related receptor α (ERRα).

2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterated form of 2-Acetamidophenol. This compound (Orthocetamol) acts as a regulator targeting both ferroptosis and the glutathione metabolism pathway and serves as the ortho-isomer of Paracetamol. It exhibits anti-atherosclerotic activity, with IC50 values of 30 μM and 40 μM for inhibiting total cholesterol (TC) and triglycerides (TG) in a zebrafish hyperlipidemia model, respectively. 2-Acetamidophenol enhances glutathione peroxidase GPX4 activity, lowers intracellular reactive oxygen species (ROS) and ferrous ion (Fe2+) accumulation, and upregulates the expression of genes related to glutathione synthesis (such as GCLC, GCLM, GSS) and iron ion transport (including FPN1, FTH), thereby inhibiting ox-LDL uptake by macrophages and foam cell formation.

Cholesterol-13C2 (Standard) is a reference standard of Cholesterol-13C2 intended for quantitative analysis, quality control, and related biochemical research applications. Cholesterol-13C2 is a 13C-labeled form of cholesterol. This primary sterol in mammals constitutes 20-25% of the plasma membrane's structural components. While the plasma membrane is highly permeable to water, it remains relatively impermeable to ions and protons. Cholesterol significantly influences membrane fluidity and permeability and is crucial for the function of transport and signaling proteins. Additionally, cholesterol acts as an endogenous agonist for estrogen-related receptor α (ERRα).

Cholesterol-13C5 (Standard) is a reference standard of Cholesterol-13C5 intended for quantitative analysis, quality control, and related biochemical research applications. Cholesterol-13C5 is a form of cholesterol labeled with carbon-13 isotopes. Cholesterol is the predominant sterol in mammals, constituting 20-25% of the plasma membrane structure. While the plasma membrane is highly permeable to water, it is relatively impermeable to ions and protons. Cholesterol is crucial in determining membrane fluidity and permeability features, as well as the function of transport and signaling proteins. Additionally, cholesterol acts as an endogenous agonist of estrogen-related receptor α (ERRα).

Cholesterol-D1 (Standard) is a reference standard of Cholesterol-D1 intended for quantitative analysis, quality control, and related biochemical research applications. Cholesterol-d1 is the deuterated form of Cholesterol. Cholesterol is the principal sterol found in mammals, comprising 20-25% of the plasma membrane's structural components. While the membrane allows high permeability to water, it remains relatively impermeable to ions and protons. Cholesterol is crucial for defining membrane fluidity and permeability characteristics, as well as for the function of transport and signaling proteins. Additionally, Cholesterol acts as an endogenous agonist of the estrogen-related receptor α (ERRα).

High density lipoprotein (HDL) (human) is a functional lipoprotein capable of binding to receptors such as scavenger receptor B1 (SR-B1), ABCA1, and ABCG1. It facilitates the removal of excess cholesterol from peripheral tissues through reverse cholesterol transport (RCT), transferring it to the liver for metabolism. Additionally, it activates endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO), offering antioxidant, anti-inflammatory, and vascular endothelial protection. High density lipoprotein (human) is a potential candidate for cardiovascular disease research, including atherosclerosis.

Sphingomyelinphosphodiesterase, derived from Bacillus cereus, is a hydrolase enzyme involved in sphingomyelin metabolism. It catalyzes the hydrolysis of sphingomyelin into phosphocholine and ceramide. Additionally, sphingomyelinphosphodiesterase plays a crucial role in cell differentiation, various immune and inflammatory responses, and in the intracellular transport and metabolism of cholesterol.