chaperones

ML346 is a novel activator of Hsp70.

NT219 is a dual inhibitor of insulin receptor substrate 1 2 (IRS1 2) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of certain molecular chaperones and inhibits STAT3 phosphorylation NT219 is useful for the study of cancer and neurodegenerative diseases.

DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones), aimed at reducing or preventing acquired chemotherapy resistance by inhibiting intracellular copper chaperones. It binds to Atox1 and CCS, thereby reducing cancer cell proliferation and tumor growth.

HS-291, a HtpG inhibitor targeting Borrelia burgdorferi (Bb), comprises BX-2819 (high affinity for Bb HtpG), a PEG linker, and Verteporfin (a photoactive toxin). Upon light activation, HS-291 generates reactive oxygen species that oxidize HtpG and selectively inactivate nearby proteins, leading to the rapid and irreversible inactivation of Bb [1].