cardiomyocytes — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10979	DCPIB		Potassium Channel , Chloride channel
	DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1...		Potassium Channel , Chloride channel
T16420	P-1075		Potassium Channel
	P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c...		Potassium Channel
T16347	NS3623		Potassium Channel
	NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic e...		Potassium Channel
T14186	17-ODYA	Alkynyl Stearic Acid	Others , PROTAC Linker
	17-ODYA (Alkynyl Stearic Acid) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T7714	Temocapil		Tyrosinase
	Temocapril is an inhibitor of tyrosine kinase.		Tyrosinase
T6698	Temocapril hydrochloride	CS-622 HCl,Acecol,Temocapril HCl,CS-622	RAAS
	Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.		RAAS
T8005	Cardiogenol C hydrochloride	Cardiogenol C HCl,Cardiogenol C	Wnt/beta-catenin
	Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).		Wnt/beta-catenin
T8786	VUT-MK142		Others
	VUT-MK142 is a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes,which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.		Others
T26016	R 56865	R-56865,R56865	Sodium Channel
	R 56865 is a weak potential-operated channel inhibitor that inhibits the late sodium current in human isolated cardiomyocytes.		Sodium Channel
T29670	ADR-925	ICRF198,ICRF-198,ADR 925,ICRF 198,ADR925	Endogenous Metabolite
	ADR-925 (ICRF 198), an active chelated iron metabolite of dexrazoxane, has the ability to protect neonatal rat cardiomyocytes from adriamycin-induced injury.		Endogenous Metabolite
T2052	KY02111		Wnt/beta-catenin
	KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.		Wnt/beta-catenin
T69760	TT-10	TAZ-K	YAP
	TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease research, specifically for conditions characterized by loss o...		YAP
T27064	CP-312	CP312,Cardioprotectant 312	Reactive Oxygen Species , Autophagy
	CP-312 (Cardioprotectant 312) is an antioxidant defense response activator that protects hiPSC-CM viability by acting through induction of heme oxygenase-1 and targeting the antioxidant response network by inducing HMOX1...		Reactive Oxygen Species , Autophagy
T4100	AS8351	NSC51355,AS-8351,AS 8351	Histone Demethylase
	AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblas...		Histone Demethylase
T2301	SB 202190	FHPI,SB202190	Apoptosis , p38 MAPK , Autophagy
	SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i...		Apoptosis , p38 MAPK , Autophagy
T20793	Magnesium Lithospermate B	Monomethyl lithospermate B,Lithospermate B	Others
	Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from is...		Others
T30251	AZD-1305	UNII-CZO834LXQM,AZD 1305	Others
	AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in st...		Others
T3230	NLRP3-IN-2	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR) , NOD
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i...		NOD-like Receptor (NLR) , NOD
T21871	MMPSI	Caspase-3/7 Inhibitor I	Apoptosis , Caspase
	MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a ...		Apoptosis , Caspase
T7284	Argipressin acetate (113-79-1(free base))		Others
	Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle...		Others