bzr

Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.

Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) is a paclitaxel derivative that inhibits the HSV replication cycle at low cytotoxicity, blocks mitosis in Vero cells, affects the size of M-MSV-induced tumors, and influences the immune response by inhibiting PHA-induced proliferation of T lymphocytes.

Bz-rA Phosphoramidite is employed for the modification of ribonucleotides [1].

5'-O-DMT-Bz-Rc is a modified nucleoside used in the synthesis of DNA or RNA.

Bz-rC Phosphoramidite is a phosphinamide monomer used in oligonucleotide synthesis.

5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is used in DNA or RNA synthesis.

5'-DMT-3'-TBDMS-Bz-rA is a nucleoside possessing protective and modification effects.

5'-O-DMT-Bz-rA, a nucleoside, consists of a ribose sugar attached to an adenine base with a benzoyl protecting group at the N6 position and a dimethoxytrityl (DMT) protecting group at the 5' position of the ribose.

2',5'-di-OBz-rC(Bz) is a monomer raw material used in nucleic acid synthesis.

5'-O-Bz-rA(Bz) is a monomeric raw material suitable for nucleic acid synthesis.

3'-TBS-OMe-Bz-rA is an adenosine derivative. It serves as an intermediate for the synthesis of modified oligonucleotides or other nucleic acid-related molecules.

GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.

Desfluoro-BMS-694153 (Compound 3) is an antagonist of the calcitonin gene-related peptide receptor (CGRP receptor) with a Ki of 0.01 nM. It exhibits a significantly reduced risk of CYP3A4 inhibition, with IC50 values of 36 μM for CYP3A4-BFC and 6 μM for CYP3A4-BZR. Desfluoro-BMS-694153 is useful for migraine research.

TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice.

Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo.