bifunctional

CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.

Macropa-NCS is a macropa bifunctional analog with antitumor activity and can be used to study prostate cancer.

Macropa-NH2 is a bifunctional analog of macropa, a carrier molecule that is often coupled to antibodies and is often used as a chelator in cancer research.

Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.

Adipic dihydrazide (ADH) is a dihydrazide with a symmetrical C4 skeleton, commonly used as a bifunctional cross-linking agent for water-in-oil emulsions and a curing agent for epoxy resins. ADH exhibits antibacterial activity against E. coli and P. aeruginosa.

dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.

Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Aminooxy-PEG3-C2-NH-Boc is a PEGylated PROTAC linker used in synthesizing PROTACs, a new class of bifunctional molecules for targeted protein degradation [1].

Azido-PEG4-hydrazide-Boc is a polyethylene glycol (PEG)-based bifunctional linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

N-(Azido-PEG2)-N-Boc-PEG4-Boc is a PEG-based bifunctional linker used in the synthesis of PROTACs (proteolysis-targeting chimeras).

N-Mal-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based bifunctional linker used for synthesizing Proteolysis Targeting Chimeras (PROTACs) [1].

Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.[2]

Azide-PEG3-Sulfone-PEG3-azide is a polyethylene glycol (PEG)-based bifunctional molecule, designed as a PROTAC linker for PROTAC synthesis [1].

Boc-Aminooxy-PEG2-bromide is a bifunctional, cleavable polyethylene glycol (PEG) linker used specifically in the synthesis of antibody-drug conjugates (ADCs) [1].

Fmoc-N-amido-PEG36-acid is a polyethylene glycol (PEG)-based linker used in PROTAC synthesis, designed to construct bifunctional molecules that recruit target proteins to an E3 ubiquitin ligase for degradation[1].

m-PEG-acrylate (MW 30000) is a polyethylene glycol (PEG)-based bifunctional linker commonly used in the chemical synthesis of proteolysis targeting chimeras (PROTACs)[1].

N-Desthiobiotin-N-bis(PEG4-t-butyl ester) is a PEG-based linker compound used in the synthesis of PROTACs, which are bifunctional molecules aimed at targeted protein degradation[1].

Sulfo-SIAB sodium is a non-cleavable monovalent bifunctional linker.

Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.

t-Boc-Aminooxy-PEG7-bromide is a polyethylene glycol (PEG)-based bifunctional linker used in synthesizing proteolysis targeting chimeras (PROTACs)[1].

Thiol-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG) derivative frequently used in the construction of PROTACs, bifunctional compounds designed for targeted protein degradation [1].

BFCAs-1 is a polyamine polycarboxylic bifunctional chelating agent (BFCAs) with a broad range of applications in biology, chemistry, medicine and diagnostic imaging.

XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1 K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.

Propargyl-NOTA(tBu)2 is a bifunctional chelating ligand that can bind to radionuclides to prepare radionuclide conjugates (RDCs).