bh 4

TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an N-terminal eosin-labeled cysteine and the protein transduction domain of the HIV TAT protein (amino acids 49 to 57), fused to the Bcl-xL BH4 peptide. It serves as a tool for research into diseases characterized by accelerated apoptosis [1].

"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an eosin-labeled cysteine at the N-terminal and the protein transduction domain from the HIV TAT protein (amino acids 49 to 57), fused to the Bcl-xL BH4 peptide. It is utilized in research concerning diseases associated with accelerated apoptosis [1]."

2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis

Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and an essential cofactor for nitric oxide synthase (NOS), which is used in the study of endothelial dysfunction such as hypertension, hypercholesterolemia, and diabetes.

Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatonin, norepinephrine, neurotransmitter

BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-apoptotic entity. This compound effectively suppresses lung cancer cell growth[1].

Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.

cis-tert-butyl 8-fluoro-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate ,with CAS No. 1251015-03-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. cis-tert-butyl 8-fluoro-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5a,9-dimethyl-3-methylidene-2H,3H,3aH,4H,5H,5aH,8H,9bH-naphtho[1,2-b]furan-2,8-dione is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3a,8-dihydroxy-3,5a,9-trimethyl-2H,3H,3aH,4H,5H,5aH,6H,7H,8H,9bH-naphtho[1,2-b]furan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

6-hydroxy-3,5a,9-trimethyl-2H,3H,3aH,4H,5H,5aH,6H,7H,9aH,9bH-naphtho[1,2-b]furan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

8,9-dihydroxy-7-methoxy-2,4a,9b-trimethyl-4H,4aH,5H,9bH-indeno[1,2-b]pyran-4-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

4-hydroxy-6,9-dimethyl-3-methylidene-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azuleno[4,5-b]furan-2,8-dione is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

6a-hydroxy-6,9a-dimethyl-3-methylidene-2H,3H,3aH,4H,5H,6H,6aH,9H,9aH,9bH-azuleno[4,5-b]furan-2,9-dione is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3a-hydroxy-3,5a,9-trimethyl-2H,3H,3aH,4H,5H,5aH,6H,7H,8H,9bH-naphtho[1,2-b]furan-2,8-dione is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

6,8,9-trihydroxy-3,6,9-trimethyl-2-oxo-2H,3H,3aH,4H,5H,6H,8H,9H,9aH,9bH-azuleno[4,5-b]furan-4-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-hydroxy-6,7b-dimethyl-1H,2H,2aH,4aH,5H,6H,7H,7aH,7bH-cyclobuta[e]indene-3,6-dicarboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

BBH-4 is an inhibitor of the SARS-CoV-2 main protease (MPro) and is applicable in research related to SARS-CoV-2 infection.