at 61

AT-61 is a nonnucleoside analogue inhibitor of hepatitis B virus (HBV) replication.

LB-60-OF61 is a NAMPT inhibitor that exhibits antiproliferative activity against MYC oncogene-dependent cancer cell lines (brackets).

[4-(Tetrahydropyran-4-yloxy)phenyl]methylamine hydrochloride (864266-61-5 Free base) ,with CAS No. 2514927-90-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. [4-(Tetrahydropyran-4-yloxy)phenyl]methylamine hydrochloride (864266-61-5 Free base) provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Tubulin polymerization-IN-61 (Compound 9a), a tubulin polymerization inhibitor, disrupts the microtubule skeleton, arrests the cell cycle at the G2/M phase, induces Apoptosis, and impedes cancer cell migration and colony formation. This compound demonstrates antitumor efficacy in vivo within the 4T1 xenograft model [1].

Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.

Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.

HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).

NLRP3-IN-61 (Compound 1) is an inhibitor of NLRP3. It suppresses pyroptosis in THP-1 cells with an IC50 of 12.6 nM and inhibits IL-β release with an IC50 of 25.3 nM.

VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.

Arachidonylcyclopropylamide (AM1241) is a highly effective and selective agonist for the CB2R. This compound specifically targets the CB2 receptor, making it a valuable tool for research and therapeutic applications that exploit CB2-specific pathways without affecting CB1 receptors.

α-Glucosidase-IN-61 (Compd 1j) is a competitive inhibitor of α-glucosidase, with an IC50 value of 0.73 μM. It is utilized in research related to type 2 diabetes.

HDAC6-IN-61 (Compound 4e) is an HDAC6 inhibitor with an IC50 of 73 nM, demonstrating greater selectivity compared to other HDAC isomers. It also acts as an activator of GPR40. HDAC6-IN-61 can increase the acetylation of tubulin and phosphorylation levels of ERK. This compound is relevant for studying neuroinflammation, including Alzheimer's disease.

LO-3-61 is a JQ-1 analog featuring a truncated fumarylamide group, classified as a BRD4 degrader with PROTAC (protein degradation targeting chimera) properties. It promotes the degradation of both long and short BRD4 isoforms via a CUL4DCAF16-dependent pathway. In MDA-MB-231 cells, LO-3-61 exhibits selectivity in degrading BRD3 and BRD4.

HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.

RI 61 (sumatriptan succinate) is utilized in the therapy of migraine, cluster headaches, new daily persistent headache, and cyclic vomiting syndrome.

BFE-61 is a partial agonist of the beta-adrenoceptors.

HT-61, a pyrroloquinolone antibiotic, is used potentially for the treatment of staphylococcal infections.

Ro 61-1448 is a metabolite of tolcapone, a catechol-O-methyltransferase inhibitor.

61A2, known as a stabilizer of the active LPL dimer can prevents LPL inactivation.

GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.

RO-61-0591 is a bioactive chemical.

RO-61-0593 is a bioactive chemical.

RO-61-3662 is a bioactive chemical.

Influenza Matrix Protein (61-72) is a peptide derived from the matrix protein of influenza viruses, encompassing amino acids 61-72, and has the ability to elicit a CD4+ T-cell response.