anti-septic

Ginsenoside Rg4 is a natural product

Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene utilized topically as an antiseptic for minor skin infection treatment.

Ethacridine lactate hydrate is a topically applied anti-infective agent.

Ethacridine lactate (Acrinol) is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.

Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.

8-Hydroxyquinoline hemisulfate (Oxyquinoline sulfate) is an antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action

2,5-Dihydroxybenzaldehyde (Gentisaldehyde) has antioxidant activity against Mycobacterium avium subsp. Paratuberculosis. 2,5-Dihydroxybenzaldehyde also inhibits S. aureus strains(MIC50: 500 mg/L).

Methenamine Hippurate is a component of Hiprex, with antibacterial activity.

Comanthoside B (Comanthosid B) is a natural product isolated from the aerial portions of Ruellia tuberosa L with anti-inflammatory and antiseptic activities.

SIRT5 inhibitor 7 (compound 58), a substrate-competitive and selective SIRT5 inhibitor with IC 50 = 310 nM, significantly attenuated renal dysfunction and pathological damage in lipopolysaccharide (LPS)- and cecum ligation/perforation (CLP)-induced septic AKI mice, and modulated proteinsuccinimidylation and proinflammatory cytokine release and pro-inflammatory cytokine release in the kidneys of acute kidney injury (AKI) mice.

Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.

TNF-α/IL-1β-IN-1 (compound 11a) is an anti-inflammatory agent that effectively reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and myocardial cell apoptosis, and demonstrates significant activity against septic myocardial injury. Additionally, it improves myocardial blood flow in vivo.

BPD is a COX-2 and TAK1-NF-κB inhibitor with an IC50 of 18.5 μM for COX-2. It suppresses the expression of iNOS, TNF-α, IL-6, and IL-1β at the transcriptional level. BPD possesses anti-inflammatory properties and can inhibit carrageenan-induced paw edema as well as LPS-induced septic death.

Anti-inflammatory agent 109 (Compound 2m) is an anti-inflammatory compound. It directly interacts with p65, reducing the abnormal activation of the NF-κB pathway. This agent significantly inhibits the release of key pro-inflammatory mediators, such as IL-1β, COX-2, and iNOS. Additionally, Anti-inflammatory agent 109 offers substantial protection against LPS-induced acute liver injury in septic mice.

HDAC3degrader-1 (Compound Z8) is a selective HDAC3 degrader with a DC50 of 2.42 μM. It shows minimal impact on HDAC1, HDAC2, and HDAC6. By inhibiting the activation of the NLRP3 inflammasome, HDAC3degrader-1 reduces the secretion of IL-1β and caspase-1. It demonstrates significant efficacy in models of septic shock and colitis, making it valuable for anti-inflammatory research.

HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, showing no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At 30 μM, it reduces IL-1β, TNF-α, and caspase-1 p20 levels, inhibits NF-κB p65 phosphorylation, and provides anti-apoptotic effects. In vivo, 15 mg/kg of HMGB1-IN-2 administered intraperitoneally alleviates kidney injury in a mouse model of septic acute kidney injury. Additionally, it inhibits Huh7 and A549 cells with IC50 values of 77.0 μM and 82.0 μM, respectively [1].

Ginsenoside Rg4 (Standard) is a reference standard for research and analysis in studies involving Ginsenoside Rg4. Ginsenoside Rg4 is isolated from the leaves of Panax ginseng C. A. Meyer. Ginsenoside Rg4 is a protopanaxatriol type ginsenoside with anti-septic, anti-diabetic, wound healing, immune-stimulatory, and anti-antioxidant properties.

Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis.