aicar

AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors.

AICAR monophosphate (Aica ribonucleotide) is a purine precursor with antineoplastic activity and can be used in studies about type 2 diabetes.

AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy. It serves as an adenosine analog, regulating glucose and lipid metabolism, and inhibiting the production of pro-inflammatory cytokines and iNOS.

SAICAR, an intermediate of de novo purine nucleotide biosynthesis, selectively activates pyruvate kinase isoform M2 (PKM2) with an EC50 of 0.3 mM.

FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.

ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.

ATIC-IN-1 acetate is an inhibitor of aminoimidazole-carboxamide ribonucleotide transformylase inosine monophosphate cyclohydrolase (ATIC) with potential anti-tumor activity. It inhibits AICAR Tfase by disrupting ATIC homo-dimerization.

ATIC-IN-1 (compound 14) is an inhibitor targeting the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase inosine monophosphate cyclohydrolase (ATIC), with a K i of 685 nM. This dimerization is crucial for the enzyme's AICAR transformylase function. Additionally, ATIC-IN-1 exhibits anti-tumor properties by reducing cell proliferation and cell division rates [1].

MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity.