adenosinedeaminase

Erdosteine (RV 144) is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus production and viscosity, by which facilitating mucociliary transport and improving expectoration. This agent also suppresses the chemical-induced cough reflex as well as protects lung tissues from damages caused by cigarette smoking mediated through free radicals scavenging.

Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.

EHNA hydrochloride is a selective inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA) with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner. EHNA hydrochloride inhibits PHA and NaI04 mitogenesis.

Pentostatin (CI-825) is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).

8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.

3'-O-Methyladenosine is an antiviral compound with inhibitory activity against West Nile Virus and can be used for the treatment of viral infections.3'-O-Methyladenosine inhibits adenosine deaminase type VII with a Ki value of 493 µM.

1-Deazaadenosine, a potent Adenosine deaminase inhibitor (Ki: 0.66 μM), exhibits anti-cancer activities in vitro and holds potential as a chemotherapy agent for lymphoproliferative disorders.

AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, useful for studying anorexia in the nervous system.

Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of 2'-deoxyadenosine and adenosine to 2'-deoxyinosine and inosine, respectively.

ADAR1-IN-1 is a potent ADAR1 inhibitor. It significantly suppresses the proliferation of DU-145 cells (IC50 = 1.11 μM), inhibits colony formation, migration, and invasion, and induces cell cycle arrest and apoptosis. ADAR1-IN-1 effectively and safely impedes tumor growth and can be utilized in prostate cancer (PCa) research.

Coformycin is a ribonucleoside antibiotic synergist and adenosine deaminase inhibitor.

FR-221647 is a non-nucleoside adenosine deaminase inhibitor, it has moderate activity and good pharmacokinetics compared with the known inhibitors EHNA and pentostatin.

FR-234938 is a non-nucleoside adenosine deaminase inhibitor with anti-inflammatory activity.

L-Adenosine is a useful organic compound for research related to life sciences. The catalog number is T65008 and the CAS number is 3080-29-3.

Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It also inhibits the growth of HeLa human cervical cancer cells (IC50 = 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.

AMPD2 Inhibitor 2 is a potent inhibitor of AMP deaminase 2 (AMPD2), demonstrating inhibitory concentration 50 (IC50) values of 0.1 μM for human AMPD2 (hAMPD2) and 0.28 μM for mouse AMPD2 (mAMPD2). This compound is valuable for research into the physiological roles of AMPD2, especially in mice on a high-fat diet.

E.coli tRNA adenosine deaminase is derived from Escherichia coli and functions as an adenosine deaminase. It effectively deaminates adenine within single-stranded RNA (ssRNA, primarily in the loop regions of tRNA) or double-stranded RNA (dsRNA) but lacks deaminase activity on DNA. This enzyme is a protein-engineered mutant form of adenosine deaminase, efficiently deaminating adenine in ssDNA, making it useful for adenine base editing (ABE) and RNA m6A methylation sequencing.