T2125

Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.

OSW-1 is a natural broad-range inhibitor to inhibits replication of enterovirus.

DHMB (2,3-Dihydroxy-4-Methoxybenzaldehyde) exerts protective effects on intestinal epithelial cells. DHMB exhibits anti-inflammatory and antifungal capacity.

Campestanol is a natural plant sterol from Brassica campestris.

PROTAC Androgen receptor degrader-1 (Ex. 14) is a PROTAC degrader targeting the androgen receptor (DC50 = 6 nM), which can be used for the study of prostate cancer.

4-Benzoyl-L-phenylalanine is an L-phenylalanine derivative and optically active amino acid. It may be incorporated as a photolabelling agent into synthetic peptides to identify residues involved in peptide-protein interactions.

Mafenide acetate, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.

MEK Inhibitor II (2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone) is a selective MEK1 inhibitor (IC50=0.38 μM) that inhibits tubulin polymerization in Trypanosoma cruzi (IC50=6 μM) and exhibits inhibitory activity against trypanosomes (IC50=2.77 μM).

Quindoxin is a potent antibacterial agent that has been rigorously evaluated for genetic toxicity using the Salmonella microsomal assay system, where experimental testing demonstrated that this compound induces both base pair substitution mutations and frameshift mutations in Salmonella strains independently of the presence of a rat liver microsomal fraction, with mutagenic activity shown to be mechanistically dependent on the presence of its N-oxide functional group, as fully reduced quinoxaline lacked mutagenicity while partially reduced quinoxaline-N-oxide displayed diminished activity, and recA- and uvrB-deficient Salmonella strains exhibited increased susceptibility compared with wild-type strains.

3-(2-Hydroxyethyl)-2,4-(1H,3H)-quinazoline-dione is a specialized biomedical research reagent extensively utilized in chemical constituent synthesis, medicinal chemistry optimization, and experimental biological pathway research,the unique molecular structure supports structure–activity relationship studies, molecular interaction analysis, and the development of bioactive compounds with potential pharmacological and translational research applications.

ARUK2010489 (Compound 23) is a potent, selective, and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7, also exhibiting partial inhibitory activity against CDK2, CDK4, and CDK6 at micromolar concentrations, and it is applied in neurological disease research, including mechanistic studies related to Alzheimer’s disease.

(Z/E)-Gingerenone A is an isomer of Gingerenone A and can be used in biochemical experiments and drug synthesis research. Gingerenone A is a regulator of the Nrf2-GPX4 pathway, which can induce ferroptosis and exhibits anti-inflammatory and anti-tumor effects.

FABP4/5-IN-2 is a potent dual inhibitor of fatty acid binding protein 4 (FABP4) and fatty acid binding protein 5 (FABP5) that robustly interferes with intracellular lipid trafficking and fatty acid signaling pathways, making it a valuable pharmacological tool for investigating metabolic inflammation, insulin resistance, and lipid-driven disease mechanisms in both in vitro and in vivo experimental systems.