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Search Results for " palbociclib "

16

Compounds

Cat No. Product Name Synonyms Targets
T1785 Palbociclib PD 0332991 CDK
Palbociclib (PD 0332991) is a CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM) and is orally active. Palbociclib has anti-tumorigenic activity and has investigational potential for use in ER-positive and HER2-ne...
T6239 Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,Palbociclib (PD-0332991) HCl CDK
Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases.
T6240 Palbociclib Isethionate Palbociclib (PD0332991) Isethionate,PD 0332991 isethionate CDK
Palbociclib Isethionate (PD 0332991 isethionate) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases.
T28291 Palbociclib-Succinic acid Palbociclib-hemi Succinic acid,Palbociclib-Succinate,
Palbociclib-Succinic acid is a Palbociclib- derivative with a succinic acid linker. The carboxy group of Palbociclib-Succinic acid can be used to conjugate with other molecules such as peptides, proteins, or polymers. Pa...
T12355 Palbociclib-d8 PD 0332991 D8,Palbociclib D8 CDK
Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively).
T33865 Palbociclib-SMCC PD0332991-SMCC,Palbociclib-SMCC linker,PD 0332991-SMCC,PD-0332991-SMCC
Palbociclib-SMCC is a Palbociclib derivative with a SMCC linker.
T18515 Palbociclib-propargyl PROTAC CDK6 ligand 1 Others
Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].
T72507 Palbociclib orotate PD 0332991 orotate CDK
Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively. This compound demonstrates potent anti-proliferative effects and induces cell c...
T63634 Palbociclib dihydrochloride
Palbociclib (PD 0332991) dihydrochloride is an orally active, selective inhibitor of CDK4 (IC50: 11 nM) and CDK6 (IC50: 16 nM). Palbociclib dihydrochloride has anti-proliferative activity and cell cycle arrest in HR-posi...
T63576 Palbociclib hydrochloride
Palbociclib (PD 0332991) hydrochloride is a selective and potent inhibitor of CDK4 (IC50: 11 nM) and CDK6 (IC50: 16 nM). Palbociclib hydrochloride has anti-proliferative effects on cancer cells and induces cell cycle arr...
T64486 6-Desacetyl Palbociclib
6-Desacetyl Palbociclib is a useful organic compound for research related to life sciences and the catalog number is T64486.
T78130 N-Methyl Palbociclib Drug Metabolite
N-Methyl Palbociclib is an impurity of the orally active selective CDK4 and CDK6 inhibitor Palbociclib (PD 0332991).
T20656 Verapamil NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil P450 , Calcium Channel , P-gp
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias...
T1010 Verapamil hydrochloride Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride P450 , Calcium Channel , P-gp
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T60098 MSC2504877 3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one Others
MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phos...
T77923 BSJ-03-204 triTFA CDK
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degradation of CDK4/6. It exhibits IC50 values of 26.9 nM for CDK4...
TargetMol