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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1785 | Palbociclib | PD 0332991 | CDK |
Palbociclib (PD 0332991) is a CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM) and is orally active. Palbociclib has anti-tumorigenic activity and has investigational potential for use in ER-positive and HER2-ne... | |||
T6239 | Palbociclib monohydrochloride | PD 0332991 hydrochloride,Palbociclib hydrochloride,Palbociclib (PD-0332991) HCl | CDK |
Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases. | |||
T6240 | Palbociclib Isethionate | Palbociclib (PD0332991) Isethionate,PD 0332991 isethionate | CDK |
Palbociclib Isethionate (PD 0332991 isethionate) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases. | |||
T28291 | Palbociclib-Succinic acid | Palbociclib-hemi Succinic acid,Palbociclib-Succinate, | |
Palbociclib-Succinic acid is a Palbociclib- derivative with a succinic acid linker. The carboxy group of Palbociclib-Succinic acid can be used to conjugate with other molecules such as peptides, proteins, or polymers. Pa... | |||
T12355 | Palbociclib-d8 | PD 0332991 D8,Palbociclib D8 | CDK |
Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively). | |||
T33865 | Palbociclib-SMCC | PD0332991-SMCC,Palbociclib-SMCC linker,PD 0332991-SMCC,PD-0332991-SMCC | |
Palbociclib-SMCC is a Palbociclib derivative with a SMCC linker. | |||
T18515 | Palbociclib-propargyl | PROTAC CDK6 ligand 1 | Others |
Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1]. | |||
T72507 | Palbociclib orotate | PD 0332991 orotate | CDK |
Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively. This compound demonstrates potent anti-proliferative effects and induces cell c... | |||
T63634 | Palbociclib dihydrochloride | ||
Palbociclib (PD 0332991) dihydrochloride is an orally active, selective inhibitor of CDK4 (IC50: 11 nM) and CDK6 (IC50: 16 nM). Palbociclib dihydrochloride has anti-proliferative activity and cell cycle arrest in HR-posi... | |||
T63576 | Palbociclib hydrochloride | ||
Palbociclib (PD 0332991) hydrochloride is a selective and potent inhibitor of CDK4 (IC50: 11 nM) and CDK6 (IC50: 16 nM). Palbociclib hydrochloride has anti-proliferative effects on cancer cells and induces cell cycle arr... | |||
T64486 | 6-Desacetyl Palbociclib | ||
6-Desacetyl Palbociclib is a useful organic compound for research related to life sciences and the catalog number is T64486. | |||
T78130 | N-Methyl Palbociclib | Drug Metabolite | |
N-Methyl Palbociclib is an impurity of the orally active selective CDK4 and CDK6 inhibitor Palbociclib (PD 0332991). | |||
T20656 | Verapamil | NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil | P450 , Calcium Channel , P-gp |
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias... | |||
T1010 | Verapamil hydrochloride | Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride | P450 , Calcium Channel , P-gp |
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent. | |||
T60098 | MSC2504877 | 3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one | Others |
MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phos... | |||
T77923 | BSJ-03-204 triTFA | CDK | |
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degradation of CDK4/6. It exhibits IC50 values of 26.9 nM for CDK4... |