PKI(5-24) TFA

PKI(5-24) TFA is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), characterized by its potent and competitive inhibition properties, exhibiting a K i of 2.3 nM. It corresponds to residues 5-24 found in the natural heat-stable protein kinase inhibitor [1] [2].

N-Formyl-Met-Ala-Ser TFA is a peptide, binds to formyl peptide receptors on neutrophils.N-Formyl-Met-Ala-Ser Peptide (fMet-Ala-Ser) binds to formyl peptide receptors on neutrophils. N-Formylmethionine-containing peptides including the most potent and know

Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.

γ-Glu-Phe TFA(7432-24-8 free base) is a dipeptide composed of gamma-glutamate and phenylalanine and is a proteolytic breakdown product of larger proteins. It is probably formed by transpeptidation between glutathione and the corresponding amino acid, catalyzed by gamma-glutamyl transpeptidase.

PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).

Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression

JAG-1, scrambled TFA is a scrambled sequence of JAG-1(188-204).

Autocamtide 2 TFA is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 TFA can be used in the CaMKII activity assay.

Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a 16-1 expression.

Dynorphin B (1-13), a 13 amino acid, is an extraordinarily potent opioid peptide.

Adipokinetic Hormone (AKH) (24-32), locust (TFA), a neurohormone extracted from the corpora cardiaca of locusts, serves to regulate lipid utilization during flight [1].

Foxy-5 is a peptide that mimics the WNT5A protein and is expected to reduce the mobility of the cancer cells. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial c

Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.

Acetyl-PHF6 amide TFA is a tau derived hexapeptide.

Phytochelatin 5 TFA, a metal-binding compound produced by plants, may reduce the bioavailability of dietary toxic metals, such as cadmium [1].

Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds in the transmembrane domain of the κ-receptor.

Insulin-like Growth Factor I (24-41) TFA, a fragment comprising amino acids 24 to 41 of the full IGF-I TFA molecule, is a variant of IGF-I TFA, which itself is a 70 amino acid polypeptide hormone. This hormone serves as a trophic factor beneficial for both neurons and glial cells, playing a significant role in mediating the effects of growth hormone (GH) on systemic growth. Additionally, IGF-I TFA exhibits anabolic, antioxidant, anti-inflammatory, and cytoprotective properties. The specific fragment IGF-I (24-41) TFA is involved in regulating somatic growth as well as behavioral development [1] [2] [3].

Foxy-5 TFA, a WNT5A agonist and mimicking peptide of WNT5A (a non-canonical Wnt family member), induces cytosolic free calcium signaling without altering β-catenin activation. This compound inhibits the migration and invasion of epithelial cancer cells and significantly diminishes the metastatic progression of WNT5A-low prostate cancer cells in an orthotopic mouse model [1] [2] [3] [4].

TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 act

C3a (70-77) TFA (Complement 3a (70-77) TFA) is a COOH-terminal fragment of the C3a anaphylatoxin peptide.

BQ-3020 (TFA) is a selective ETB receptor agonist that inhibits [125I] et-1 binding to the ETB receptor in the cerebellum with a 0.2nm IC50, causing vasoconstriction.

PGLa TFA is a cationic antimicrobial peptide (AMP) originally isolated from frog. It has been shown to have antibacterial,antifungal,and antiviral,activities.

PKI(5-22)amide, an active inhibitory fragment of the cyclic AMP-dependent protein kinase (PKA) inhibitor, effectively prevents PKA activation. However, it does not reduce the homologous desensitization of CRF1 receptors [1] [2].

Calcitonin,eel TFA is a thyroid hormone polypeptide that can regulate calcium homeostasis and is widely used in the study of postmenopausal osteoporosis.

γ-Glu-Phe TFA is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). It enhances the umami intensity of commercial soy sauce and model chicken broth.

TNF-α (46-65), human (TFA) is a peptide of human TNF-α.

Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to inductio

CALP3 TFA is a potent Ca2+ channel blocker that activates EF-hand motifs of Ca2+-binding proteins. It can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin, Ca2+ channels, and pumps.

Histatin 5 TFA effectively inhibits host matrix metalloproteinases (MMP-2) and (MMP-9), demonstrating inhibition concentrations (IC 50s) of 0.57 μM and 0.25 μM, respectively.

PKI (5-24),amide (IP20-amide) is a potent inhibitor of cAMP-dependent protein kinase (PKA) (PKA), with an inhibition constant (K i ) of 2.3 nM [1]. This 20-residue peptide mirrors the active segment of the heat-stable inhibitor protein specific to PKA, showcasing its significant inhibitory efficacy.

Gap19 TFA is a peptide derived from nine amino acids of Cx43 cytoplasmic ring (CL), an effective, selective connexin 43 (Cx43) half-channel blocker.

β-Melanocyte Stimulating Hormone (MSH), human (Synonyms: Beta-MSH (1-22) (human)) β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

KKI-5 (TFA) is a specific tissue kallikrein inhibitor.Kki-5 (TFA) can reduce breast cancer cell infiltration.

Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium fl

KKI-5 (TFA), a specific tissue kallikrein inhibitor, has been shown to inhibit breast cancer cell invasion [1].

PKI (14-24)amide is a potent inhibitor of Protein Kinase A (PKA), demonstrating strong inhibition of cyclic AMP-dependent protein kinase activity in cell homogenates [1] [2].

PKI (14-24)amide TFA, a potent inhibitor of Protein Kinase A (PKA), significantly reduces cyclic AMP-dependent protein kinase activity within cellular homogenates, as evidenced by research findings [1] [2].

Syntide 2 (TFA) is a Ca2+ and CaM dependent protein kinase II (CaMKII) substrate peptide that selectively inhibits the gibberellin (GA) response, leaving composition and slicoic acid regulatory events unaffected.

IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).IGF-I (24-41) (TFA) is amino acids 24 to 41 fragment of Insulin-like Growth

AUNP-12 TFA (NP-12 TFA) is a polypeptide antagonist in the pd-1 signaling pathway, which has the same antagonistic effect on pd-l1 and pd-l2, and can protect the proliferation and effector function of lymphocytes.

High affinity PKA inhibitor (Ki = 2.3 nM).

PKI 14-22 amide, myristoylated TFA is a potent inhibitor of cAMP-dependent protein kinase A (PKA) that diminishes IgG-mediated phagocytic response and inhibits neutrophil adhesion [1].

Mini Gastrin I, human (TFA) is short for human Gastrin. It is a mother peptide composed of 5-17 amino acids.