mps1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16130	Mps1-IN-3		Kinesin
	Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).		Kinesin
T1839	Mps1-IN-2		Kinesin , PLK
	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.		Kinesin , PLK
T12102	Mps1-IN-1		Others
	Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )		Others
T37050	MPS1/TTK Inhibitor	MPS1/TTK Inhibitor
	MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphory...
T17007	TC-Mps1-12		Kinesin
	TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .		Kinesin
T70095	Mps1-IN-1 dihydrochloride
	Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) functio...
T64061	Mps1-IN-3 hydrochloride
	Mps1-IN-3 hydrochloride is a potent and selective inhibitor of Mps1 (IC50: 50 nM). mps1-IN-3 hydrochloride exhibits inhibitory effects on the proliferation of glioblastoma cells and effectively sensitizes glioblastomas t...
T78965	Mps1-IN-6
	Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].
T73229	Mps1-IN-4
	Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.
T73308	Mps1-IN-5
	Mps1-IN-5 is a potent, orally active Mps1 inhibitor exhibiting an IC50 of 29 nM, known for triggering apoptosis and G2/M phase cell cycle arrest. This compound demonstrates antiproliferative and anti-tumor effects by inh...
T23865	CCT-271850	MPS1-IN-77,MPS1IN77,CCT271850,CCT 271850,MPS1 IN 77
	CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.
T77779	Mps1-IN-6 (Compound 9)
	Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects on breast cancer cells.
T3434	BAY1217389		Kinesin
	BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).		Kinesin
T2689	AZ3146	AZ 3146	Kinesin
	AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.		Kinesin
T2313	MPI-0479605		Apoptosis , Kinesin
	MPI-0479605 is an ATP competitive and selective inhibitor.		Apoptosis , Kinesin
T14765	BOS-172722		Kinesin
	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).		Kinesin
T8487	Empesertib	BAY 1161909	Kinesin
	Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.		Kinesin
T12237	NMS-P715		Casein Kinase , Kinesin , MELK , MAPK
	NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).		Casein Kinase , Kinesin , MELK , MAPK
T22289	CFI-402257		Kinesin
	CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.		Kinesin
T14906	CCT251455		Kinesin
	CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).		Kinesin
T28091	Mps-BAY2b
	Mps-BAY2b is a novel MPS1 inhibitor.
T73483	RMS-07
	RMS-07, a covalent inhibitor of Monopolar Spindle Kinase 1 (MPS1/TTK), exhibits a potent inhibitory concentration (IC50) of 13.1 nM. Specifically, it targets a poorly conserved cysteine located in the hinge region of the...
T28498	Rac-CCT-250863
	Rac-CCT-250863, a potent Nek2 inhibitor, exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
T71082	DW532
	DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 val...