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Mitophagy activator 1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    2
    TargetMol | Inhibitors_Agonists
MTK458
Mitophagy activator 1, EP-0035985
T724202499962-58-0
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1 TOM complex.MTK458 may be used in Parkinson's disease research.
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6-8 weeks
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HMS607P03
T69365361198-09-6
HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP90α.
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6-8 weeks
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