Mitophagy activator 1

MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.

HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP90α.

Olaparib-d8 (AZD2281-d8) is a deuterated variant of Olaparib. Olaparib is an orally active inhibitor of PARP, specifically inhibiting PARP-1 and PARP-2 with IC50 values of 5 nM and 1 nM, respectively. Additionally, Olaparib serves as an activator of autophagy and mitophagy.

Olaparib-d4-1 (AZD2281-d4-1) is a deuterated form of Olaparib. Olaparib is an orally active PARP inhibitor, with IC50 values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Additionally, Olaparib acts as an activator of autophagy and mitophagy.