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Results for "

MPYS

" in TargetMol Product Catalog
  • Inhibitor Products
    18
    TargetMol | Activity
Vadimezan
T6273117570-53-3
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.
  • $48
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Omaveloxolone
T69191474034-05-3
Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
  • $38
In Stock
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TargetMol | Inhibitor Hot
ADU-S100 ammonium salt
T10252L21638750-96-5
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.
  • $159
In Stock
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TargetMol | Inhibitor Hot
SR-717
T86552375421-09-1
SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a closed activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.
  • $75
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TargetMol | Inhibitor Hot
H-151
T5674941987-60-6
H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.
  • $30
In Stock
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QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
C-176
T5154314054-00-7
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor
  • $39
In Stock
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
MSA-2
T8798129425-81-6
MSA-2 is a potent and orally available non-nucleotide STING agonist.
  • $34
In Stock
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TargetMol | Inhibitor Hot
SN-008
T95542249106-01-0In house
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
  • $56
In Stock
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CCCP
T7081555-60-2
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
  • $41
In Stock
Size
QTY
TargetMol | Citations Cited
STING agonist-1
T8328702662-50-8
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
diABZI STING agonist-1 trihydrochloride
T55162138299-34-8
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
  • $175
In Stock
Size
QTY
TargetMol | Citations Cited
STING-IN-2
T9028346691-38-1
STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.
  • $45
In Stock
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SN-011
T91372249435-90-1
SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
  • $48
In Stock
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STING activator Compound 53
T98532259624-71-8
STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
  • $34
In Stock
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STING-IN-3
T90292244881-69-2
STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.
  • $45
In Stock
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C-178
T7329329198-87-0
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
  • $37
In Stock
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ChX710
T136132438721-44-7
ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory Factor (IRF) 3.
  • $92
In Stock
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STING agonist-4
T130152138300-40-8
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
  • $163
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