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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4928 | L-Kynurenine | (S)-Kynurenine | AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite |
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ... | |||
T10938 | D-Kynurenine | (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103 | GPR , AhR , Endogenous Metabolite |
D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluor... | |||
T3011 | 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid | Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine | Others , Endogenous Metabolite |
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) is a ketone and an amino acid derivative with diverse biological functions, including vasodilatory, immunoregulatory and neuromodulatory activities. 2-... | |||
T3011L | Kynurenine sulfate monohydrate | L-Kynurenine sulfate monohydrate | |
Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment genera... | |||
T37683 | 3-Hydroxykynurenine | 3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine | Others |
3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%. | |||
T72430 | L-Kynurenine sulfate | ||
L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist, activates AHR-driven polarization of naive T cells towards the anti-inflammatory Treg phenotype. | |||
T1896 | Ro 61-8048 | Hydroxylase | |
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM. | |||
T4410 | LM10 | Others | |
Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters.... | |||
T71760 | 4-Chlorokynurenine | ||
4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor. | |||
T4096 | Quinolinic acid | pyridine-2,3-dicarboxylic acid,QUIN | Endogenous Metabolite , NMDAR , iGluR |
Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway. | |||
T28368 | PF-04859989 HCl | PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 | Others |
PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s... | |||
T4707 | 3-Hydroxyanthranilic acid | 3-HYDROXY-2-AMINOBENZOIC ACID | Others , Endogenous Metabolite |
3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID), also known as 2-amino-3-hydroxy-benzoate or 3-ohaa, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. 3-Hydroxyanthranilic acid... | |||
T26785 | BFF122 | BFF 122,BF5,BFF-122 | |
BFF122 is an inhibitor of kynurenine aminotransferase II (KAT II). | |||
T70041 | GSK065 | ||
GSK065 is a potent inhibitor of kynurenine-3-monooxygenase (KMO). | |||
T70701 | CHDI340246 | ||
CHDI-340246 is a potent and selective kynurenine mono-oxygenase (KMO) inhibitor. | |||
T13258L | UPF-648 | Others | |
UPF-648 is a potent kynurenine 3-monooxygenase inhibitor. It also shows highly active at 1 uM (81 ± 10% KMO inhibition). | |||
T13258 | UPF-648 sodium salt | Others | |
UPF-648 sodium salt is an inhibitor of kynurenine 3-monooxygenase (KMO) and exhibits highly active at 1 uM (81 ± 10% KMO inhibition). | |||
T11470 | GSK 366 | Hydroxylase | |
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO). | |||
T15426 | GSK180 | Hydroxylase | |
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism. | |||
T63613 | JM6 | ||
JM6 is a weak kynurenine 3-monooxygenase (KMO) inhibitor that acts on mouse KMO (IC50: 19.85 μM). JM6 can be used to study Alzheimer's disease. |