forskolin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T24365	L 858051	7B-Forskolin,L858051,Dmpb-forskolin,L-858051
	L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes.
T22467	1,9-Dideoxyforskolin		Others
	The compound is an inactive analog of forskolin(an adenylyl cyclase activator).		Others
T36720	Deacetylforskolin
	Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos...
T16516	PG01	Phenylglycine-01	CFTR
	PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508...		CFTR
TP2092L	Apelin-17 (human, bovine) acetate	Apelin-17 (human, bovine) acetate(217082-57-0 free base)	HIV Protease
	Apelin-17 (human, bovine) acetate is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).		HIV Protease
TP1922L1	ELA-11 (human) acetate(1784687-32-6 free base)		Apelin receptor , Arrestin
	ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.		Apelin receptor , Arrestin
TP1936L1	RFRP3(human) acetate(311309-27-0 free base)		Neuropeptide Y Receptor
	RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced produ...		Neuropeptide Y Receptor
T39392L	C-Type Natriuretic Peptide (CNP) (1-22), human acetate	C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base)	Others
	C-Type Natriuretic Peptide (CNP) (1-22), human acetate is an agonist of natriuretic peptide receptor B (NPR-B), an endothelial-derived relaxant and growth inhibitory factor. C-Type Natriuretic Peptide (CNP) (1-22), huma...		Others
TP1187	C-Type Natriuretic Peptide (CNP) (1-22), human	CNP (1-22), human	RAAS
	C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide.		RAAS
T10591L	(R)-BPO-27		CFTR , Autophagy
	(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.		CFTR , Autophagy
T78083	CB-25		Cannabinoid Receptor
	CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cells [1].		Cannabinoid Receptor
T33214	Manoyl oxide	Manoyl
	Manoyl oxide is a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids.
T27779	L-759,656	L 759,656,L759,656
	L-759,656 is highly selective CB2 receptor agonist (CB1 Ki = 4888 nM, CB2 Ki = 11.8 nM). L-759,656 potently inhibits forskolin-stimulated cAMP production in CHO cells (EC50 = 3.1 nM).
TP2092	Apelin-17(human, bovine)	Apelin-17 (human, bovine)
	Endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).
TP1922	ELA-11(human)	ELA-11 (human)
	High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
T39442	AM-8123
	AM-8123 is an APJ agonist with high oral bioavailability and potency. It effectively inhibits Forskolin-stimulated cAMP production and activates Gα proteins. This compound is valuable for cardiovascular disease research.
T76053	ELA-11(human) TFA
	ELA-11(human) TFA, a bioactive fragment of ELA-32, acts as a high-affinity apelin receptor agonist (K i =14 nM). It effectively inhibits forskolin-induced cAMP production and promotes β-arrestin recruitment in vitro, hig...
TP1936	RFRP-3(human)	RFRP 3 (human)
	Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
TP2001	MM 54
	Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens surviv...
T78949	AM841		Cannabinoid Receptor
	AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor. It diminishes forskolin-stimulated cAMP accumulation and slows gastroi...		Cannabinoid Receptor
T37477	L-858,051 (hydrochloride)
	L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat...
TP2096	ELA-21 (human)
	High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh...
T37131	MS 15203
	Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other re...
T75866	RFRP-3(human) TFA
	RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human homolog of the GnIH peptide, significantly suppresses gonadotropin release through inhibition of Ca 2+ mobilization. Acting as an NPFF1 receptor agonist, RFRP-3 (huma...
T39392	C-Type Natriuretic Peptide (CNP) (1-22), human TFA
	C-Type Natriuretic Peptide (CNP) (1-22), human (TFA), is a 22 amino acid fragment of CNP and functions as an agonist for the natriuretic peptide receptor B (NPR-B). It can inhibit cAMP synthesis, which is induced by hist...
T37896	AZ 1729
	FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assay...
T70035	Tasimelteon-d5
	Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ...
T35631	Peptide YY (human) (trifluoroacetate salt)	Peptide Tyrosine Tyrosine
	Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y1, Y2, Y5, and Y6 with EC50 values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-in...
T37483	Difelikefalin (trifluoroacetate salt)
	Difelikefalin is a κ-opioid receptor (KOR) agonist.1It activates KOR in HEK293 cells expressing the human receptor (EC50= 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse ...
T37199	Bilaid C
	Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.1It inhibits forskolin-induced cAMP accumulation by 77% in HEK293...
T83955	MOMBA
	MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD). It demonstrate...
T69530	Difelikefalin TFA
	Difelikefalin TFA is a κ-Opioid Receptor (KOR) agonist. Difelikefalin is selective for KOR over the μ-Opioid Receptor (MOR; EC50 = >1 µM).
T83677	Neuropeptide Y (porcine, bovine) TFA	NPY (porcine, bovine)
	Neuropeptide Y (NPY), a neuropeptide, plays roles in regulating appetite, vasoconstriction, cardiac contractility, and intestinal secretion, acting as an agonist for NPY receptors Y1, Y2, and Y5. Expressed ubiquitously, ...
T69537	Difelikefalin HCl
	Difelikefalin HCl is a κ-Opioid Receptor (KOR) agonist. Difelikefalin is selective for KOR over the μ-Opioid Receptor (MOR; EC50 = >1 µM).
T38110	Galanin (Human) (Acetate)
	Galanin (Human) (Acetate) is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist.It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1 receptors (EC50= 0.031 nM) and...
T37791	A-971432
	A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 &#181M, respectively). It inhibits forskolin-induced cAMP production in CHO cel...
T83697	PAMP-12 (human, mouse, rat, porcine, bovine) TFA	Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)
	Proadrenomedullin N-terminal 12 peptide (PAMP-12), an endogenous fragment originating from the adrenal medulla and spanning amino acids 9-20 of human PAMP-20, plays a role in causing hypotension. It functions as an agoni...

Compounds

L 858051

T24365

Synonym: 7B-Forskolin,L858051,Dmpb-forskolin,L-858051

Synonym: Phenylglycine-01

Target: CFTR

Apelin-17 (human, bovine) acetate

TP2092L

Synonym: Apelin-17 (human, bovine) acetate(217082-57-0 free base)

Target: HIV Protease

ELA-11 (human) acetate(1784687-32-6 free base)

TP1922L1

Synonym:

Target: Apelin receptor, Arrestin

RFRP3(human) acetate(311309-27-0 free base)

TP1936L1

Synonym:

Target: Neuropeptide Y Receptor

C-Type Natriuretic Peptide (CNP) (1-22), human acetate

T39392L

Synonym: C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base)

Target: Others

C-Type Natriuretic Peptide (CNP) (1-22), human

TP1187

Synonym: CNP (1-22), human

Target: CFTR, Autophagy

CB-25

T78083

Synonym:

Target: Cannabinoid Receptor

Synonym: L 759,656,L759,656

Target:

Apelin-17(human, bovine)

TP2092

Synonym: Apelin-17 (human, bovine)

Target:

ELA-11(human)

TP1922

Synonym: ELA-11 (human)

Synonym: RFRP 3 (human)

Target: Cannabinoid Receptor

L-858,051 (hydrochloride)

C-Type Natriuretic Peptide (CNP) (1-22), human TFA

Peptide YY (human) (trifluoroacetate salt)

T35631

Synonym: Peptide Tyrosine Tyrosine

Target:

Difelikefalin (trifluoroacetate salt)

Neuropeptide Y (porcine, bovine) TFA

T83677

Synonym: NPY (porcine, bovine)

Galanin (Human) (Acetate)

PAMP-12 (human, mouse, rat, porcine, bovine) TFA

T83697

Synonym: Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)

Target:

Cat No.	Product Name	Synonyms	Targets
T2939	Forskolin	Coleonol,Colforsin	FXR , Adenylyl cyclase , AChR , Autophagy
	Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...		FXR , Adenylyl cyclase , AChR , Autophagy
TN4073	Forskolin G		Others
	Forskolin is known to elevate intracellular cAMP levels.		Others
TN4074	Forskolin J		Others
	Forskolin J is a natural product for research related to life sciences. The catalog number is TN4074 and the CAS number is 81873-08-7.		Others
TN1520	Isoforskolin	Coleonol B	IL Receptor , TNF
	Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis.		IL Receptor , TNF
T5081	Adenine monohydrochloride hemihydrate	Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate	Endogenous Metabolite , Adenosine Receptor
	Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor a...		Endogenous Metabolite , Adenosine Receptor
T16332	NKH477	Colforsin dapropate hydrochloride	NMDAR
	NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cyt...		NMDAR

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Compounds

Natural Products

Compounds

Natural Products