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Search Results for " duocarmycin "

18

Compounds

Cat No. Product Name Synonyms Targets
T11120 Duocarmycin TM DNA Alkylation , Antibiotic
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T11119 Duocarmycin DM free base Duocarmycin Others
Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone elect...
T18324 MC-Val-Cit-PAB-duocarmycin chloride MC-Val-Cit-PAB-duocarmycin Others
MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting si...
T11118 Duocarmycin SA Others
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastom...
T11115 Duocarmycin GA Others
Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a s...
T11117 Duocarmycin MB Others
Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T11116 Duocarmycin MA Others
Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T19300 Duocarmycin Analog DNA Alkylation
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T15180 Duocarmycin A Caspase
Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically ...
T12813L Seco-Duocarmycin SA DNA Alkylation
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T12875 Seco-Duocarmycin TM Others
Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).
T12813 (S)-Seco-Duocarmycin SA Others
(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates.
T17982 Fmoc-Val-Cit-PAB-Duocarmycin TM Others
Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB.
T73948 Duocarmycin DM
Duocarmycin DM, a toxin for antibody-drug conjugates (ADCs), functions as a DNA minor-groove alkylator. It exerts its anticancer activity through a distinct curved indole structure combined with a spirocyclopropylcyclohe...
T18293 Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA Others
Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker that incorporates the antitumor antibiotic Duocarmycin SA, connected through the Mal-PEG4-VC-PAB-DMEA-Seco linker, for targeted cancer therapy...
T63523 Duocarmycin analog-2
Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers.
T38611 Seco-DUBA
Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).
T70462 Pibrozelesin
Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
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