Duocarmycin

Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.

Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance.

Duocarmycin MA, an antibody drug conjugates (ADCs) toxin, is a DNA alkylating agent that binds in the minor groove and can be used against multi-drug resistant cell lines.

Duocarmycin MB, an antibody-drug conjugate (ADCs) toxin, is a DNA alkylating agent that binds in the minor groove and can be used against multi-drug resistant cell lines.

Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.

Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.

(S)-Seco-Duocarmycin SA is a DNA alkylating agent and antibiotic with potent antitumor activity that can be used to synthesize ADC compounds.

Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.

Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate intended for antibody-drug conjugation (ADC), employing the antitumor antibiotic Duocarmycin TM and connected via the linker Fmoc-Val-Cit-PAB.

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker, integrating the antitumor antibiotic Duocarmycin SA via the Mal-PEG4-VC-PAB-DMEA-Seco linker, aimed at targeted cancer therapy.

MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.

Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.

Mal-PEG4-VC-PAB-DMEA-duocarmycin SA is a thiol-reactive Drug-linker. Duocarmycin SA is a highly effective and orally active cytotoxic agent that can be used in the synthesis of antibody-drug conjugates (ADCs).

MA-PEG4-VC-PAB-DMEA-duocarmycin TM is a thiol-reactive Drug-linker. Duocarmycin TM is an effective antibiotic with anti-tumor activity, and is commonly used in the synthesis of antibody-drug conjugates (ADC).

Mal-PEG4-VC-PAB-DMEA-duocarmycin-DM is a thiol-reactive Drug-linker. Duocarmycin DM is a DNA alkylating agent that can be used as a toxin for ADC conjugates and is employed in the synthesis of antibody-drug conjugates (ADCs).

DBCO-PEG4-VC-PAB-DMEA-Duocarmycin SA is a click-reactive Drug-linker that contains a DBCO group and can undergo strain-promoted acylnitridation addition reaction (SPAAC) with molecules containing azide groups. Duocarmycin SA is a highly effective and orally active cytotoxic agent. DBCO-PEG4-VC-PAB-DMEA-Duocarmycin SA can be used in the synthesis of antibody-drug conjugates (ADC).

MA-PEG4-VC-PAB-DMEA-duocarmycin DM TFA is a component of antibody-drug conjugates (ADC), specifically a drug-linker conjugate for ADC. It comprises the DNA minor groove alkylating agent Duocarmycin DM linked via the linker MA-PEG4-vc-PAB-DMEA.

Duocarmycin analog-2, a potent DNA alkylating agent, exhibits antitumor effects and can be utilized in the synthesis of immunocouplers.

Duocarmycin DM, a toxin for antibody-drug conjugates (ADCs), functions as a DNA minor-groove alkylator. It exerts its anticancer activity through a distinct curved indole structure combined with a spirocyclopropylcyclohexadienone electrophile [1] [2].

MA-PEG4-VC-PAB-DMEA-Duocarmycin DM is a drug-linker conjugate for ADC, utilizing the anticancer antibiotic Duocarmycin DM, linked via MA-PEG4-VC-PAB-DMEA [1] [2].

Compound LD-1 (G3-VC-PAB-DMEA-Duocarmycin DM) is a linker molecule based on duocarmycin that is utilized in the preparation of ADCs [1].

Duocarmycin SA intermediate-2 is an intermediary compound in the synthesis of the antibiotic Duocarmycin SA. It can induce sequence-selective alkylation of double-stranded DNA (alkylation) and exhibits synergistic anticancer cytotoxicity when combined with proton radiation.