Duocarmycin

Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.

Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance.

Duocarmycin MA, an antibody drug conjugates (ADCs) toxin, is a DNA alkylating agent that binds in the minor groove and can be used against multi-drug resistant cell lines.

Duocarmycin MB, an antibody-drug conjugate (ADCs) toxin, is a DNA alkylating agent that binds in the minor groove and can be used against multi-drug resistant cell lines.

Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.

Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.

(S)-Seco-Duocarmycin SA is a DNA alkylating agent and antibiotic with potent antitumor activity that can be used to synthesize ADC compounds.

Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.

Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

Duocarmycin A (GMP) refers to the GMP grade reagents of Duocarmycin A. Duocarmycin A is an anti-tumor antibiotic that belongs to the class of DNA methylating agents. It can effectively methylate the N3 of adenine at the 3' end of sequences rich in adenine in DNA. As a chemotherapy drug, Duocarmycin A causes typical apoptotic changes in HLC-2 cells.

Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate intended for antibody-drug conjugation (ADC), employing the antitumor antibiotic Duocarmycin TM and connected via the linker Fmoc-Val-Cit-PAB.

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker, integrating the antitumor antibiotic Duocarmycin SA via the Mal-PEG4-VC-PAB-DMEA-Seco linker, aimed at targeted cancer therapy.

MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.

Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.

Mal-PEG4-VC-PAB-DMEA-duocarmycin SA is a thiol-reactive Drug-linker. Duocarmycin SA is a highly effective and orally active cytotoxic agent that can be used in the synthesis of antibody-drug conjugates (ADCs).

MA-PEG4-VC-PAB-DMEA-duocarmycin TM is a thiol-reactive Drug-linker. Duocarmycin TM is an effective antibiotic with anti-tumor activity, and is commonly used in the synthesis of antibody-drug conjugates (ADC).

Mal-PEG4-VC-PAB-DMEA-duocarmycin-DM is a thiol-reactive Drug-linker. Duocarmycin DM is a DNA alkylating agent that can be used as a toxin for ADC conjugates and is employed in the synthesis of antibody-drug conjugates (ADCs).

DBCO-PEG4-VC-PAB-DMEA-Duocarmycin SA is a click-reactive Drug-linker that contains a DBCO group and can undergo strain-promoted acylnitridation addition reaction (SPAAC) with molecules containing azide groups. Duocarmycin SA is a highly effective and orally active cytotoxic agent. DBCO-PEG4-VC-PAB-DMEA-Duocarmycin SA can be used in the synthesis of antibody-drug conjugates (ADC).

Duocarmycin analog-2, a potent DNA alkylating agent, exhibits antitumor effects and can be utilized in the synthesis of immunocouplers.

Duocarmycin DM, a toxin for antibody-drug conjugates (ADCs), functions as a DNA minor-groove alkylator. It exerts its anticancer activity through a distinct curved indole structure combined with a spirocyclopropylcyclohexadienone electrophile [1] [2].

MA-PEG4-VC-PAB-DMEA-Duocarmycin DM is a drug-linker conjugate for ADC, utilizing the anticancer antibiotic Duocarmycin DM, linked via MA-PEG4-VC-PAB-DMEA [1] [2].

Compound LD-1 (G3-VC-PAB-DMEA-Duocarmycin DM) is a linker molecule based on duocarmycin that is utilized in the preparation of ADCs [1].

Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).