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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11120 | Duocarmycin TM | DNA Alkylation , Antibiotic | |
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic. | |||
T11119 | Duocarmycin DM free base | Duocarmycin | Others |
Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone elect... | |||
T18324 | MC-Val-Cit-PAB-duocarmycin chloride | MC-Val-Cit-PAB-duocarmycin | Others |
MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting si... | |||
T11118 | Duocarmycin SA | Others | |
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastom... | |||
T11115 | Duocarmycin GA | Others | |
Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a s... | |||
T11117 | Duocarmycin MB | Others | |
Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. | |||
T11116 | Duocarmycin MA | Others | |
Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. | |||
T19300 | Duocarmycin Analog | DNA Alkylation | |
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin. | |||
T15180 | Duocarmycin A | Caspase | |
Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically ... | |||
T12813L | Seco-Duocarmycin SA | DNA Alkylation | |
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin. | |||
T12875 | Seco-Duocarmycin TM | Others | |
Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC). | |||
T12813 | (S)-Seco-Duocarmycin SA | Others | |
(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates. | |||
T17982 | Fmoc-Val-Cit-PAB-Duocarmycin TM | Others | |
Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB. | |||
T73948 | Duocarmycin DM | ||
Duocarmycin DM, a toxin for antibody-drug conjugates (ADCs), functions as a DNA minor-groove alkylator. It exerts its anticancer activity through a distinct curved indole structure combined with a spirocyclopropylcyclohe... | |||
T18293 | Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA | Others | |
Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker that incorporates the antitumor antibiotic Duocarmycin SA, connected through the Mal-PEG4-VC-PAB-DMEA-Seco linker, for targeted cancer therapy... | |||
T63523 | Duocarmycin analog-2 | ||
Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers. | |||
T38611 | Seco-DUBA | ||
Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs). | |||
T70462 | Pibrozelesin | ||
Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. |