dgk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39982	DGK-IN-1
	DGK-IN-1, an extracted T cell activator, holds potential in leveraging tumor immunity.
T22726	Dioctanoylglycol	2-octanoyloxyethyl octanoate,Dioctanoyl ethylene glycol,Ethylene glycol dioctanoate,ethane-1,2-diyl dioctanoate	Others
	Dioctanoylglycol (ethane-1,2-diyl dioctanoate) is a diacylglycerol kinase inhibitor.		Others
T82573	DGKζ-IN-3
	DGKζ-IN-3 is an inhibitor of diacylglycerol kinase zeta (DGK-ζ), employed in the treatment of both liquid and solid cancers, as well as other diseases regulated by DGK-ζ [1].
T79824	DGKα&ζ-IN-1
	DGKα&ζ-IN-1 (Compound II) is an inhibitor targeting DGK that potentiates T-cell function and exhibits a synergistic interaction with PD-1, offering therapeutic benefits in immune and tumor contexts [1].
T79825	DGKζ-IN-4
	DGKζ-IN-4 is a DGK-zeta inhibitor employed as an active ingredient in pharmaceutical formulations designed to treat cancers linked to immune cell activation or those resistant to anti-PD-1/anti-PD-L1 antibody treatments ...
T79828	DGKα-IN-8
	DGKα-IN-8 (Example 51) is a potent diacylglycerol kinase alpha (DGKα) inhibitor, exhibiting an IC50 of 22.491 nM and an EC50 of 0.256 nM. It is applicable in the research of cancer, particularly solid tumors, and viral i...
T79826	DGKα-IN-6
	DGKα-IN-6, a diacylglycerol kinase alpha (DGKα) inhibitor characterized by an inhibitory concentration (IC50) of 1.377 nM,holds promise for use in cancer research.
T38210	Hodgkinsine B
	Hodgkinsine B is an alkaloid and isomer of hodgkinsine that has analgesic activity.1It increases the latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 10 mg/kg. 1.Kodanko, J.J., Hie...
T79136	DGKζ-IN-1
	DGKζ-IN-1 (compound 9) is a DGKζ inhibitor with potential applications in cancer research, particularly for studying immunocyte activation and resistance to anti-PD-1/anti-PD-L1 antibody therapies [1].
T79827	DGKα-IN-7
	DGKα-IN-7 is a potent DGKα inhibitor with an IC50 value of 6.225 nM and potential applications in cancer research.
T79821	DGKα-IN-2
	DGKα-IN-2 (example 48), a potent DGKα inhibitor with an IC50 of 0.9 nM, exhibits potential for cancer and immunological research by significantly augmenting the anti-tumor efficacy of anti-PD-1 therapy through the amplif...
T79822	DGKα-IN-3
	DGKα-IN-3 (example 25), with an IC50 of 283 nM, is a selective DGKα inhibitor that augments anti-PD-1's anti-tumor activity by promoting T cell proliferation and function, showing promise for cancer and immunology resear...
T38209	Hodgkinsine
	Hodgkinsine is a pyrrolidinoindoline alkaloid that has been found inP. colorataand has analgesic activity.1It increases latency to paw licking in the hot plate test and latency to tail withdrawal in the tail-flick test i...
T79823	DGKα-IN-4
	DGKα-IN-4 (example 432), an inhibitor of DGKα with an IC50 value of 0.1 nM. This compound notably potentiates the anti-tumor efficacy of anti-PD-1 therapy through augmentation of T cell proliferation and function. Additi...
T72322	R 59-022 hydrochloride	DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor , PKC
	R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R...		5-HT Receptor , PKC
T77761	BMS-502		Others
	BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune respo...		Others
T26019	R59949	R-59949,R 59949	Others , PKC
	R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.		Others , PKC
T16709	R 59-022	Diacylglycerol kinase inhibitor I,DKGI-I	Others
	R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits ...		Others

Compounds

DGK-IN-1

T39982

Synonym: 2-octanoyloxyethyl octanoate,Dioctanoyl ethylene glycol,Ethylene glycol dioctanoate,ethane-1,2-diyl dioctanoate

R 59-022 hydrochloride

T72322

Synonym: DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride

Target: 5-HT Receptor, PKC

Synonym: R-59949,R 59949

Target: Others, PKC

R 59-022

T16709

Synonym: Diacylglycerol kinase inhibitor I,DKGI-I

Target: Others

Cat No.	Product Name	Synonyms	Targets
T69446	Cochlioquinone A
	Cochlioquinone A is an inhibitor of diacylglycerol kinase (DGK) and diacylglycerol acyltransferase (DGAT). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma and has also been shown to ...

Recombinant Proteins

Species：

Expression System：

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Cat No.	Product Name	Species	Expression System
TMPH-01211	DGUOK Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis de...
TMPH-01222	DGKA Protein, Human, Recombinant (His)	Human	E. coli
	Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pa...
TMPJ-00922	DCK Protein, Human, Recombinant (His & T7)	Human	E. coli
	Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanos...