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Cat No. | Product Name | Synonyms | Targets |
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T13148 | CHK-IN-1 | Chk | |
CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity. | |||
T79874 | CHK-336 | ||
CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluria research [1]. | |||
T10791 | CHK1-IN-3 | Chk | |
CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM). | |||
T6093 | AZD-7762 | AZD7762 | Chk |
AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. | |||
T7080 | CCT245737 | SRA737 | Chk |
CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM). | |||
T21331 | SAR-020106 | Chk | |
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme. | |||
T2517 | SCH900776 | MK 8776,MK-8776 | Chk , CDK |
SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. | |||
T6084 | Rabusertib | LY2603618,IC-83 | Chk , PDK , Autophagy |
Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance... | |||
T6350 | CHIR-124 | CHIR124,CHIR 124 | Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src |
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4. | |||
T2033 | BML-277 | C 3742,Chk2 Inhibitor II,BML 277 | Apoptosis , Chk |
BML-277 (C 3742) is a selective checkpoint kinase 2 (Chk2) inhibitor. | |||
T7300 | GDC-0575 | ARRY-575,RG7741 | Chk |
GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM). | |||
T10792 | CHK1-IN-4 | Chk | |
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity. | |||
T10790 | CHK1-IN-2 | Chk | |
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM). | |||
T10793 | CHK1 inhibitor | GDC-0575 analog | Chk |
CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor. | |||
T37098 | Chk1-IN-5 | Chk1-IN-5 | |
Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1]. | |||
T4327 | Prexasertib dihydrochloride | LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 | Apoptosis , Chk , S6 Kinase |
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively. | |||
T40091 | Chk1-IN-6 | Chk1-IN-6 | |
Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate. | |||
T4310 | Prexasertib | LY2606368 | Apoptosis , Chk |
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. | |||
T6028 | PF 477736 | PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 | c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase |
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. | |||
T10792L | CHK1-IN-4 hydrochloride | CHK1-IN-4 hydrochloride(2120398-41-4 Free base) | Chk |
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1). CHK1-IN-4 hydrochloride potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 hydrochloride has anti-tumor activity. | |||
T82393 | FLT3/CHK1-IN-1 | ||
Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstr... | |||
T34577 | Schkuhriolide | ||
Schkuhriolide is a melampolide. | |||
T29083 | V-11-0711 | V 11-0711,V110711,V-110711,V11-0711,V 110711 | |
V-11-0711 is an inhibitor of Chk-α, which may be essential in cancer cell proliferation. | |||
T80132 | CBP501 Affinity Peptide | ||
CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1]. |
Cat No. | Product Name | Synonyms | Targets |
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T83321 | 4-Demethyldeoxypodophyllotoxin | Chk | |
4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells. |
Cat No. | Product Name | Species | Expression System |
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TMPY-04368 | Chk1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)... | |||
TMPY-04435 | CHEK2 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putativ... | |||
TMPY-04681 | CHEK2 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putativ... | |||
TMPY-04433 | Chk1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)... |