cxcr2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10905	CXCR2-IN-1		CXCR
	CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.		CXCR
T36923	CXCR2-IN-2	CXCR2-IN-2
	CXCR2-IN-2 is a selective CXCR2 antagonist that is brain penetrant and orally bioavailable, with IC50 values of 5.2 nM and 1 nM in the β-arrestin assay and CXCR2 Tango assay, respectively. It exhibits approximately 730-f...
T16850	SB-265610	GSK-CXCR2	CXCR
	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and...		CXCR
T36443	(R,R)-CXCR2-IN-2	(R,R)-CXCR2-IN-2
	(R,R)-CXCR2-IN-2, a diastereoisomer of CXCR2-IN-2 (compound 68), functions as a brain-penetrant CXCR2 antagonist. It exhibits a pIC50 of 9 in the Tango assay and 6.8 in the HWB Gro-α induced CD11b expression assay[1].
T33763	NVP CXCR2 20	NVP-CXCR2 20,NVP CXCR2-20,NVP CXCR220
	NVP CXCR2 20 is an effective selective CXCR2 antagonist (IC50 = 40 nM) with oral bioavailability.
T61386	CXCR2 antagonist 2
	CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.
T61359	CXCR2 antagonist 6
	CXCR2 antagonist 6 (compound 35c) is a potent CXCR2 antagonist. CXCR2 antagonist 6 shows potent CXCR2 binding affinity ( IC 50 =0.044 μM) and calcium mobilization ( IC 50 =0.66 μM) [ 1].
T61235	CXCR2 antagonist 5
	CXCR2 antagonist 5 (compound 25) is a potent CXCR2 antagonist. CXCR2 antagonist 5 shows potent CXCR2 binding affinity ( IC 50 =0.013 μM) and calcium mobilization ( IC 50 =0.1 μM) [ 1].
T60696	CXCR2 antagonist 8
	CXCR2 antagonist 8 is a potent and selective antagonist of CXCR2 that can be used for the researching of insulin resistance [1].
T61447	CXCR2 antagonist 4
	CXCR2 antagonist 4 (compound 7) is a highly potent antagonist that inhibits CXCR2 with an IC50 value of 0.13 μM. It also effectively inhibits the cytosolic calcium increase induced by CXCL8, with an IC50 value of 27 μM. ...
T61236	CXCR2 antagonist 7
	CXCR2 antagonist 7 (compound 19) is a potent CXCR2 antagonist. CXCR2 antagonist 7 shows potent CXCR2 binding affinity ( IC 50 =0.044 μM) and calcium mobilization ( IC 50 =0.66 μM) [ 1].
T61356	CXCR2 antagonist 3
	CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar po...
T11179	Elubrixin	SB-656933	IL Receptor , CXCR
	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat...		IL Receptor , CXCR
T1955	SB225002		CXCR
	SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.		CXCR
T7681	AZD-5069		CXCR
	AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).		CXCR
T5193	Danirixin	GSK1325756	CXCR
	Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).		CXCR
T4163	Reparixin	DF 1681Y,Repertaxin	CXCR
	Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).		CXCR
T7130	Navarixin	MK-7123,SCH 527123	CXCR
	Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be benef...		CXCR
T3047	SRT3109		CXCR
	SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.		CXCR
T14384	AZD8797	KAN-0440567,KAND567	CXCR
	AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially protects against SARS-CoV-2-induced neuronal damage, preventi...		CXCR