amidase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T80051	Amidase		Endogenous Metabolite
	Amidases, belonging to the nitrilase superfamily, catalyze amide hydrolysis to yield carboxylic acid and ammonia. These enzymes feature a conserved AS sequence of about 130 amino acids and are pivotal in essential metabo...		Endogenous Metabolite
T78361	Penicillin amidase	Penicillin acylase
	Penicillin amidase (Penicillin acylase) is an enzyme utilized for cleaving the acyl side chains from penicillins. It facilitates the production of 6-aminopenicillanic acid and is also employed in resolving racemic mixtur...
T75142	Acid Ceramidase-IN-2
	Acid Ceramidase-IN-2 (compound 1), an acid ceramidase inhibitor, exhibits potentially antiproliferative and cytostatic effects. This compound is of interest due to the overexpression of human acid ceramidase in prostate ...
T40051	Acid Ceramidase-IN-1
	Acid Ceramidase-IN-1 is a highly effective and orally bioavailable inhibitor of acid ceramidase (AC, ASAH-1), with an inhibitory concentration (IC50) of 0.166 μM. Additionally, Acid Ceramidase-IN-1 exhibits exceptional b...
T75407	Endoglycoceramidase I (EGCase I)
	Endoglycoceramidase I (EGCase I), a glycosidase frequently utilized in biochemical studies, catalyzes a transglycosylation reaction. This process involves transferring the sugar moiety of GSLs to the primary hydroxyl gro...
T75406	Endoglycoceramidase II (EGCase II)
	Endoglycoceramidase II (EGCase II), an endo-β-glucosidase, catalyzes the hydrolysis of the β-glycosidic linkage between oligosaccharides and ceramides in glycosphingolipids, releasing the complete glycan from ceramide [1...
T68492	AM 374	HDSF,Hexadecanesulfonyl fluoride	FAAH
	AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease resear...		FAAH
T41032	Lysostaphin		Antibacterial
	Lysostaphin is a potent antistaphylococcal compound that exhibits enzymatic activity through three distinct enzymes: glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase, and N-acetyl muramyl-L-alanine amidase.		Antibacterial
T15948	MAFP	Methyl Arachidonyl Fluorophosphonate	Phospholipase
	MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2.		Phospholipase
T9528	ARN19702		Others
	ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC 50 of 230 nM for human NAAA. ARN19702 exhibits a broad analgesic profile [1] [2].		Others
T77513	2-Chlorophenylboronic acid		FAAH
	2-Chlorophenylboronic acid is a monohalogenated phenylboronic acid, which is an important pharmaceutical intermediate and is widely used in the synthesis of new drugs.2-Chlorophenylboronic acid has an inhibitory effect o...		FAAH
T10370	ARN 077	URB913	Others
	ARN 077 is a selective N-acylethanolamine acid amidase (NAAA) inhibitor (IC50: 7 nM for human NAAA). ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS.		Others
T60456	ARN726
	ARN726 is a potent inhibitor of NAAA (N-acylethanolamine acid amidase) with an IC 50 of 0.073 μM which decreases the motivation for alcohol in a dose-dependent manner [1] [2].
T30137	ARN14686
	ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry.
T76145	Clostripain
	Clostripain (Clostridiopeptidase B), a proteolytic enzyme derived from Clostridium histolyticum, exhibits esterase, amidase, and protease activities. It is notably specific for cleaving carboxy-terminal arginine residues...
T75412	Peptide-N-Glycosidase F (PNGaseF)
	Peptide-N-Glycosidase F (PNGase F), an asparagine amidase, catalyzes the detachment of N-linked oligosaccharides from the innermost GlcNAc to asparagine residues within high mannose, hybrid, and complex oligosaccharides ...
T60378	NAAA-IN-2
	NAAA-IN-2 (Compound 9), a potent and selective inhibitor of NAAA, exhibits an IC50 of 50 nM. NAAA, a cysteine amidase, primarily breaks down the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OE...
T60767	NAAA-IN-1
	NAAA-IN-1 (Compound 1) can be used in the inflammation and pain research. NAAA-IN-1 is a potent and selective NAAA inhibitor (IC 50 = 7 nM). NAAA is a cysteine amidase. NAAA preferentially hydrolyzes the endogenous bioli...
T37930	15(R)-17-phenyl trinor Prostaglandin F2α	15(R)-17-phenyl trinor Prostaglandin F2α
	17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl tr...
T60432	NAAA-IN-3
	NAAA-IN-3 (Compound 17a) is a potent and selective NAAA inhibitor with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanola...