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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9687 | MAGL-IN-4 | His121 ARG57 | Lipase |
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases. | |||
T9374 | AA38-3 | 1-Piperidinecarboxylic acid, 4-nitrophenyl ester | FAAH , Lipase , MAGL |
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH) | |||
T15635 | JZP-430 | Lipase , MAGL | |
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL... | |||
T11785 | KT203 | MAGL | |
KT203 is a selective and potent structural domain 6 (ABHD6) inhibitor of alpha/beta hydrolytic enzymes with potential antiviral and anti-inflammatory activity for the study of pneumonia. | |||
T11784 | KT182 | MAGL | |
KT182 is a selective and potent inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells. | |||
T22171 | WWL123 | MAGL | |
WWL123 is a potent and selective ABHD6 inhibitor (IC50=430 nM). WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole... | |||
T8997 | WWL229 | Others | |
WWL229 is a selective inhibitor of Ces3 . WWL229 acts by inhibiting recombinant Ces3 but not Ces1f, ABHD6 or other tested serine hydrolases, and recapitulating the effects of WWL113 in adipocytes. | |||
T17260 | WWL70 | Lipase , MAGL | |
WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM). | |||
T15668 | KT185 | Others | |
KT185 is an orally-bioavailable and brain-penetrant ABHD6 inhibitor (IC50: 0.21 nM in Neuro2A cells). | |||
T27653 | JCP-265 | ||
JCP-265 is an ABHD6 inhibitor. | |||
T27652 | JCP-170 | JCP170 | |
JCP-170 is an ABHD6 inhibitor. | |||
T29045 | UCM710 | ||
UCM710 is a dual inhibitor of α/β hydrolase domain 6 (ABHD6) and fatty acid amide hydrolase (FAAH). | |||
T75022 | JZP-MA-11 | ||
JZP-MA-11 is a positron emission tomography (PET) ligand that specifically targets the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. It exhibits selective inhibition of ABHD6, achieving an IC50 value of 126 nM a... | |||
T73317 | JZP-MA-13 | ||
JZP-MA-13 is a selective α/β-hydrolase domain 6 (ABHD6) inhibitor, demonstrating impressive specificity with an IC50 value of 392 nM, and exhibits no inhibitory effects on monoacylglycerol lipase (MAGL), ABHD12, fatty ac... | |||
T27811 | LEI-106 | ||
LEI-106, a novel potent sn-1 DAGLalpha inhibitor, blocks the hydrolysis of sn-1-oleoyl-2-AG, inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6. | |||
T38031 | (R)-KT109 | (R)-KT109 | |
(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also... | |||
T40226 | FP-Biotin | ||
FP-biotin is a potent organophosphorus toxicant, ideal for identifying novel biomarkers of organophosphorus toxicant exposure. It measures FAAH, ABHD6, and MAG-lipase activity, specifically in plasma studies, due to the ... | |||
T38148 | (S)-KT109 | (S)-KT109 | |
(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLβ (IC50 = 39.81 nM), DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC... | |||
T38316 | ABC34 | ||
ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than ... | |||
T27703 | JZP-361 | JZP361,JZP 361 | Lipase |
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in ... | |||
T38107 | JJH260 | JJH260 | |
JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value... | |||
T12826 | SA57 | FAAH | |
SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH). |