12-lox

2-TEDC is a potent lipoxygenase (LOX) inhibitor with inhibitory effects on 5-LOX, 12-LOX, and 15-LOX with IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively.2-TEDC can be used in the study of atherosclerosis.

CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM).

ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.

PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the cyclooxygenase enzymes. PF-4191834

NCTT-956 is a potent and specific inhibitor of platelet 12-lipoxygenase (12-LOX) activity.

Hepoxilin A3 (HXA3) is a neutrophil chemoattractant synthesized through the activation of the PLA2-12-LOX pathway. It directs neutrophils to migrate across epithelial barriers to sites of infection, such as the alveolar space. In mouse models, levels of Hepoxilin A3 rise in tandem with neutrophil infiltration. It is used in research on inflammatory diseases like pneumonia and cystic fibrosis.

ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).

YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose-dependently reduces the production of PGE2 with EC50=12 μM in IL-1β-stimulated A549 cells [1].

12(S)-HETrE is an endogenous metabolite produced by oxidation of ω-6 PUFA dihomo-γ-linolenic acid (DGLA) by 12-lipoxygenase (12-LOX) in platelets, which acts on Gαs-coupled G-protein-coupled receptors, has antithrombotic properties, and has potential therapeutic use in cardiovascular disease. 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.

12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LOE. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.

ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 12 μM, demonstrating significant anti-inflammatory and neuroprotective properties, including strong protection against glutamate toxicity.

MLS000099089 is a selective and potent inhibitor of recombinant human 12/15-LOX and cellular murine 12/15-LOX.

12-HETE-D8 is a deuterated form of 12-HETE. As the primary metabolite of arachidonic acid catalyzed by 12-LOX, 12-HETE (T35507) inhibits apoptosis. It facilitates NF-κB activation and nuclear translocation via the integrin-linked kinase (ILK) pathway. Additionally, 12-HETE (T35507) exhibits both antithrombotic and prothrombotic effects and serves as a neuromodulator.