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Cytokines and Growth Factor Receptors

Cytokine receptors are receptors that bind to cytokines. They may be both membrane-bound and soluble. Soluble cytokine receptors are extremely common regulators of cytokine function. Soluble cytokine receptors typically consist of the extracellular portions of membrane-bound receptors. In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been directly linked to certain debilitating immunodeficiency states.

Growth factor receptors are receptors that binds to a growth factors. A majority of growth factor receptors consists of receptor tyrosine kinases. There are 3 dominant receptor types that are exclusive to research : the epidermal growth factor receptor, the neurotrophin receptor, and the insulin receptors.All growth factor receptors are membrane bound and composed of 3 general protein domains: extracellular, transmembrane, and cytoplasmic.The extracellular domain region is where a ligand may bind, usually with very high specificity.


Vascular Endothel... 37 Transforming Grow... 65 Epidermal Growth ... 86 Interleukin Recep... 323 Interferon Recept... 26 Fibroblast Growth... 71 Tumor Necrosis Fa... 281 Platelet-Derived ... 23 Others 194