1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK NFκB and Jak2 STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydromethysticin and Desmethoxy yangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism.

Piperlonguminine, an alkaloid amide isolated from the Piper species, exhibits anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal, and antibacterial activities. It inhibits Akt/mTOR signaling, promotes autophagy, and mediates cancer cell death.

NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

piperitone is a natural compound from Piper nigrum L

Valeramide is an amide compound isolated from the roots of Ottonia anisum Spreng.

4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical and singlet oxygen scavenging properties.

p-Hydroxy-5,6-dehydrokawain (4'-Hydroxydehydrokawain) is isolated from Kawain.

5,6-Dihydropyridin-2(1H)-one exhibits toxicity toward MCF 10A cells and HEPG2.2.15 cells, making it suitable for cancer research.

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.

Isotschimgin is a natural product for research related to life sciences. The catalog number is TN4337 and the CAS number is 62356-47-2.

Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa

1-(4-Methoxycinnamoyl)pyrrole is a natural product for research related to life sciences. The catalog number is TN2474 and the CAS number is 736140-70-8.

Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.

Piperlotine C shows potent antiplatelet aggregation activity.

Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.

3-Phenyl-1-(pyrrol-1-yl)propan-1-one is a natural product for research related to life sciences. The catalog number is TN2980 and the CAS number is 112448-69-8.

2,2-Dimethyl-8-prenylchromene [6-carboxylic acid] demonstrated antioxidative activity.

Kadsurenin D is a natural product for research related to life sciences. The catalog number is TN4365 and the CAS number is 140669-89-2.

Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.

Dehydroformouregine is a natural product of Piper, Piperaceae. The catalog number is TN3804 and the CAS number is 107633-69-2. Dehydroformouregine can be used as a reference standard.

Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.

Isodihydrofutoquinol B is a natural product of Piper, Piperaceae. The catalog number is TN4282 and the CAS number is 62499-71-2. Isodihydrofutoquinol B can be used as a reference standard.

Methyl 3-(4-methoxyphenyl)propanoate is a natural product for research related to life sciences. The catalog number is TN4528 and the CAS number is 15823-04-8.