Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23.

1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).

Piperlonguminine, an alkaloid amide isolated from the Piper species, exhibits anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal, and antibacterial activities. It inhibits Akt mTOR signaling, promotes autophagy, and mediates cancer cell death.

(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.

Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation.

Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neurons and astroglia, decreases peak amplitude of voltage-gated Na+ channels in hippocampal neurons, and suppresses growth of Fusarium, Trichoderma, and Colletotrichum.

N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).

NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

Decanedioic acid (Sebacinsaure) is a saturated, straight-chain naturally occurring dicarboxylic acid.

piperitone is a natural compound from Piper nigrum L

4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical and singlet oxygen scavenging properties.

Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma.

1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydromethysticin and Desmethoxy yangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism.

Dihydrokavain (Marindinin), a prominent kavalactone in the kava plant, significantly contributes to the plant's anxiolytic effects, as evidenced by a study conducted on chicks.

Valeramide is an amide compound isolated from the roots of Ottonia anisum Spreng.

5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.

(E)-Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.

Methyl (E)-4-hydroxycinnamatee is found in several plants such as onion or Morinda citrifolia. It induces apoptosis in combination with Carnosic Acid and kills acute myeloid leukemia cells. It has antioxidant and antibacterial activity.

3-(3,4,5-Trimethoxyphenyl)propanoic acid, a constituent of Piper retrofractum and Piper longum, is found in herbs and spices.

Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.

Isotschimgin is a natural product for research related to life sciences. The catalog number is TN4337 and the CAS number is 62356-47-2.

Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.

1-(4-Methoxycinnamoyl)pyrrole is a natural product for research related to life sciences. The catalog number is TN2474 and the CAS number is 736140-70-8.

Piperlotine C shows potent antiplatelet aggregation activity.

Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.

Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.

3-Phenyl-1-(pyrrol-1-yl)propan-1-one is a natural product for research related to life sciences. The catalog number is TN2980 and the CAS number is 112448-69-8.

Kadsurenin D is a natural product for research related to life sciences. The catalog number is TN4365 and the CAS number is 140669-89-2.

2,2-Dimethyl-8-prenylchromene [6-carboxylic acid] demonstrated antioxidative activity.

Isodihydrofutoquinol B is a natural product of Piper, Piperaceae. The catalog number is TN4282 and the CAS number is 62499-71-2. Isodihydrofutoquinol B can be used as a reference standard.

Dehydroformouregine is a natural product of Piper, Piperaceae. The catalog number is TN3804 and the CAS number is 107633-69-2. Dehydroformouregine can be used as a reference standard.

Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.

Stigmastane-3,6-dione has anti-inflammatory activity. 5 alpha-Stigmastane-3,6-dione shows antifeedant activity against bell weevils.

Methyl trans-3-(3,4,5-trimethoxyphenyl)acrylate is a natural product for research related to life sciences. The catalog number is TN4556 and the CAS number is 20329-96-8.

3'-Demethoxypiplartine is a natural product for research related to life sciences. The catalog number is TN2922 and the CAS number is 130263-10-4.

Futokadsurin C can inhibit nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which is activated by lipopolysaccharide and interferon-gamma.

Nervogenic acid has antioxidative, pro-coagulant, and antibacterial activities, it exhibits higher activity than that of t-butyl-4- hydroxyanisole (BHA) using the ferric thiocyanate method.

N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).

Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-κB inhibitory effects, with the IC50 value of 16.25 ± 2.19 uM.

p-Hydroxy-5,6-dehydrokawain (4'-Hydroxydehydrokawain) is isolated from Kawain.

Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.

1-(3,4-Dimethoxycinnamoyl)piperidine is a natural product

Methyl 3-(4-methoxyphenyl)propanoate is a natural product for research related to life sciences. The catalog number is TN4528 and the CAS number is 15823-04-8.

Isofutoquinol A is a natural product for research related to life sciences. The catalog number is TN4292 and the CAS number is 62499-70-1.

Ethyl 3-(4-methoxyphenyl)propanoate is a natural product for research related to life sciences. The catalog number is TN4019 and the CAS number is 22767-72-2.

4-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid is a natural product of Piper, Piperaceae. The catalog number is TN3036 and the CAS number is 155051-85-7. 4-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid can be used as a reference standard.

4-O-Demethylisokadsurenin D is a natural product for research related to life sciences. The catalog number is TN3054 and the CAS number is 89104-59-6.

3,5-Diprenyl-4-hydroxybenzaldehyde is a natural product for research related to life sciences. The catalog number is TN2901 and the CAS number is 52275-04-4.