Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose uptake by C2C12 cells.Serpentine increases the expression of GSK-3β mRNA in muscle tissues, which enhances glucose uptake.Serpentine also increases glucose production and hepatic gluconeogenesis.Serpentine has a significant effect on glucagon secretion and hepatic gluconeogenesis. Serpentine significantly increased glucagon secretion and hepatic gluconeogenesis. In high-fat diet streptozotocin (HFD STZ)-induced diabetic mice, Serpentine significantly prolonged insulin hypoglycemia, significantly decreased exogenous insulin use, and inhibited endogenous insulin secretion.
Reserpine hydrochloride (Serpivite hydrochloride) is the salt form of Reserpine, an alkaloid that inhibits the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral axon terminals, with antihypertensive and antipsychotic potential.
Vellosimine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN5224 and the CAS number is 6874-98-2. Vellosimine can be used as a reference standard.
3-Hydroxysarpagine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2953 and the CAS number is 857297-90-6. 3-Hydroxysarpagine can be used as a reference standard.
A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.
Perakine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2051 and the CAS number is 4382-56-3. Perakine can be used as a reference standard.
Antirhine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN3425 and the CAS number is 16049-28-8. Antirhine can be used as a reference standard.
10-Hydroxy-16-epiaffinine, a natural product of Rauvolfia (Apocynaceae), has the catalog number TN6039 and the CAS number 82513-70-0. It can be used as a reference standard.
Raucaffricine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN4894 and the CAS number is 31282-07-2. Raucaffricine can be used as a reference standard.
10-Hydroxydihydroperaksine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2568 and the CAS number is 451478-47-0. 10-Hydroxydihydroperaksine can be used as a reference standard.