Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.

Hypaconine, a C19-diterpenoid alkaloid isolated from Aconitum and Delphinium spp., exhibits strong cardiac activity.

Higenamine hydrochloride (norcoclaurine HCl) has been demonstrated to be a β2 adrenoreceptor agonist. Adrenergic receptors, or adrenoceptors, belong to the class of G protein–coupled receptors, and are the most prominent receptors in the adipose membrane, besides also being expressed in skeletal muscle tissue.

Benzoylmesaconine (Mesaconine 14-benzoate) is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis. Benzoylmesconine has analgesic activity. Benzoylmesconine may improve the resistance of T6S-mice (or thermally injured mice) to the infection of HSV-1, through the induction of antagonistic CD4+ T cells against burn-associated type-2 T cells.

Hecogenin (Hocogenin), a steroid saponin derived from Agave sisalana, serves as a specific inhibitor for human UDP-glucuronosyltransferases. Notably, it exhibits a broad range of pharmacological activities, such as anti-inflammatory, antifungal, and gastroprotective effects[1].

Hypaconitine, an active and highly toxic constituent derived from Aconitum species, possesses anti-inflammatory activity and is widely used to treat rheumatism.

Benzoylaconine (Isaconitine) is an alkaloid in the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconine and aconitine can induce reproductive toxicity in BeWo Cell, the amino acid metabolism was the main metabolic pathway and responsible for the placental and fetal toxicity of them.

1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treatment of neurodegenerative diseases such as arthritis.

Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and immune suppression.

Chasmanine is a natural diterpenoid alkaloid with an IC50 of 6.78 mg/L for Fe2+ chelation activity and exhibits cytotoxicity against PC-3 and A-549 cells.

Benzoylmesaconine hydrochloride has used as the reference standard to evaluate the quality of processed aconite root and powdered processed aconite root.

Carmichaenine E is a natiral product from Aconitum carmichaeli.

14-Benzoylneoline is a natural product from Aconitum carmichaeli.

3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.

Carmichaenine B is a natiral product from Aconitum carmichaeli.

1. Denudatine has effects on action potential of ventricular fibers and has inhibition on arrhythmogenic action of aconitine.

Szechenyine is a natural product from Aconitum brachypodum Diels.

Guan-fu base G is derived from the tuberous root of the Aconitum aurantium plant.

Nagarine has toxic and analgesic effects.

Aconicarchamine B is a natural diterpene alkaloid suitable for biochemical experiments and drug synthesis research.

Ludaconitine is a natural product discovered in Aconitum spicatum, exhibiting anti-Leishmania activity (IC₅₀ = 36.10 μg/mL).

Foresaconitine is a natural product

Carmichaenine A is a natiral product from Aconitum carmichaeli.

Songoramine(10 uM) demonstrates significant hERG K+ channel inhibition.