Chelating Agents

EGTA-AM (EGTA Acetoxymethyl ester) is a calcium chelator, a metabolic biomarker of early-onset preeclampsia and late-onset preeclampsia.

BAPTA-AM is a calcium chelator that is cell-permeable and selective, blocking hERG, hKv1.3, and hKv1.5 channels (IC50=1.3/1.45/1.23 μM). BAPTA-AM has a 105-fold higher affinity for Ca2+ than for Mg2+, and can be used for the role of calcium in cell signaling.

Ethylenebis(oxyethylenenitrilo)tetraacet is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.

BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.

o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation.

Trientine-2HCl (Trien), a chelating agent, is used to treat Wilson's disease by binding up and removing copper in the body. Trientine can also be used as a chelating agent for copper in hepatolenticular degeneration, as a stabilizer for epoxy resins, and as ampholyte for isoelectric focusing.

Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells.

Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins.

Edetate calcium disodium(EDTA calcium disodium) , a chelating agent, is primarily used for the management of severe lead poisoning.

Edetic acid (Ethylenediaminetetraacetic acid) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.

HEDTA is a chelating agent often used in combination with citric acid to study blood disorders and blood stress in the brain.

Ethyleneurea (Imidazolidinone) is used as a formaldehyde scavenger and intermediate.

Trans-1,2-Cyclohexanediaminetetraacetic acid (CDTA) is a cyclohexane derivative and a multidentate chelating agent with strong chelating ability towards divalent and trivalent metal ions, comparable to EDTA. It is commonly used as a metal ion chelating agent, titrant, and radiopharmaceutical ligand.

Isophthalic acid is an aromatic dicarboxylic acid primarily used as a raw material for the production of polyester resins, alkyd resins, and unsaturated polyester resins, and is widely applied in research and experimentation within the life sciences field.

BAPTA, tetrapotassium salt is a Ca2+ chelator.

It has been granted to have property to inhibit protein isoprenyl transferases.

2',3'-O-Isopropylidene-6-mercaptopurine riboside is a compound with excellent metal complexation activity. It is utilized in the study of mechanisms involving metal complexation.

(S)-p-SCN-Bn-DOTA is a bifunctional chelator (Bifunctional Chelator; BFC), serving as a macrocyclic DOTA derivative for tumor pre-targeting. It is utilized for the conjugation of peptides and radionuclides.

NOTA-bis(tBu)ester (NOTA-bis(t-Butylester)) is a derivative of NOTA and serves as a bifunctional chelator suitable for drug conjugation.

Butyne-DOTA-tris(t-butyl ester) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative utilized for tumor pre-targeting. It is suitable for conjugation with peptides and radionuclides.

DO2A is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting. It is applicable for conjugation with peptides and radionuclides.

p-NH2-Bn-oxo-DO3A is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used in tumor pre-targeting. It can be employed for the conjugation of peptides and radionuclides.

4-Aminobutyl-DOTA is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative utilized for tumor pre-targeting. It is applicable for conjugation with peptides and radionuclides.

Barzuxetan (hydrochloride) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pretargeting. It is suitable for conjugation with peptides and radionuclides.