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(Rac)-Nedisertib

Catalog No. T12672 CAS 1637542-34-7

Synonyms: (Rac)-M3814

(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of <a href="/target/DNA_PK" style="display: inline; color: #c13a36">DNA-PK</a>(IC50 of <3 nM).

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(Rac)-Nedisertib, CAS 1637542-34-7

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 970.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
Targets&IC50	DNA-PK:3 nM
In vitro	(Rac)-Nedisertib potently inhibits DNA-PK with an IC50 of <3 nM for DNA-PK, 0.5-5 μM for cellular pDNA-PK and 15-25 μM for KV11.1 (hERG, human ether a-go-go related gene).

Synonyms	(Rac)-M3814
Molecular Weight	481.91
Formula	C24H21ClFN5O3
CAS No.	1637542-34-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (207.51 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.

Related Products

Related compounds with same targets

DMNB AZD-7648 OSI-027 SF2523 ETP-45658 PIK-75 hydrochloride PI-3065 PI3K-IN-1

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(Rac)-Nedisertib 1637542-34-7 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling DNA-PK (Rac)Nedisertib (Rac)-M3814 (Rac) Nedisertib Inhibitor inhibitor inhibit

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