Src

Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in invertebrates such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellates, but the SrcA and SrcB subfamilies are specific to vertebrates. Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail.

Cat. No.	Product name	CAS No.	Purity
T3319	Scutellarein	529-53-3	99.7%
T3319	Scutellarein reduces inflammatory responses by inhibiting Src kinase activity.
T13194	CSF1R-IN-2	2271119-26-5	99.71%
T13194	CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
T6321	Tofacitinib	477600-75-2	99.74%
T6321	Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
T1667	Tandutinib	387867-13-2	99.74%
T1667	Tandutinib (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R an...
T1811	WH-4-023	837422-57-8	99.75%
T1811	WH-4-023 is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.
T2624	OSI-930	728033-96-3	99.76%
T2624	OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
T32613	LCB 03-0110 dihydrochloride	1962928-28-4	99.76%
T32613	LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 fami...
T1835	Ibrutinib	936563-96-1	99.79%
T1835	Ibrutinib is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T6886	MCB-613	1162656-22-5	99.8%
T6886	MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.
T6920	ON123300	1357470-29-1	99.84%
T6920	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
T3593	Src Inhibitor 1	179248-59-0	99.84%
T3593	Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor.
T2640	Rebastinib	1020172-07-9	99.84%
T2640	DCC-2036 (Rebastinib) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT...
T3935	1-Naphthyl PP1	221243-82-9	99.85%
T3935	1-Naphthyl PP1 is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)
T4071	Repotrectinib	1802220-02-5	99.86%
T4071	TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T2327	Pelitinib	257933-82-7	99.86%
T2327	Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
T6680	Staurosporine	62996-74-1	99.87%
T6680	Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
T1448L	Dasatinib monohydrate	863127-77-9	99.89%
T1448L	Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoti...
T1448	Dasatinib	302962-49-8	99.89%
T1448	Dasatinib is a potent inhibitor of the Bcr-Abl and Src family (IC50s: 0.6, 0.8, 79 and 37 nM for Abl, Src, c-Kit, and c-KitD816V, respectively).
T2341	KW-2449	1000669-72-6	99.89%
T2341	KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
T0152	Bosutinib	380843-75-4	99.9%
T0152	Bosutinib is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.