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S1P Receptor

T2026 CYM5442 CYM5442 is an S1P agonist, targeting to Sphingosine.
T2539 Fingolimod hydrochloride Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T3258 Ponesimod Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating ...
T3961 CYM 5541 CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T4031 S1p-receptor-agonist-1 An S1P receptor agonist.
T4658 MHP MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
T6085 PF-543 PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T6403 Siponimod BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM,respectively. The specifi...
T6673 SKI II SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKC...
T6750 ABC294640 ABC294640 is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
T6923 Ozanimod Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, ...
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